Metal coordinated compositions

Abstract

A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.

1 . A metal coordination complex of a biologically active moiety and a metal, wherein 
 the biologically active moiety is selected from the group consisting of thyronine, tetracycline antibiotics, dimethylbiguanide, hydrochlorothiazide, acycloguanosine, hydrocodone, oxycodone, and their derivatives, and    the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.    
   
   
       2 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of thyronine and its derivatives.  
   
   
       3 . A complex according to  claim 2 , wherein the complex is bis(triiodothyroninato)zinc.  
   
   
       4 . A complex according to  claim 2 , wherein the complex is bis(triiodothyroninato)magnesium.  
   
   
       5 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of tetracycline antibiotics and their derivatives.  
   
   
       6 . A complex according to  claim 4 , wherein the complex is bis(tetracyclinato)magnesium.  
   
   
       7 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of oxycodone and its derivatives.  
   
   
       8 . A complex according to  claim 7 , wherein the complex is (oxycodone)magnesium.  
   
   
       9 . A complex according to  claim 7 , wherein the complex is (oxycodone)zinc.  
   
   
       10 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of hydrocodone and its derivatives.  
   
   
       11 . A complex according to  claim 10 , wherein the complex is his (hydrocodonato)magnesium.  
   
   
       12 . A complex according to  claim 10 , wherein the complex is his (hydrocodonato)zinc.  
   
   
       13 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of penicillin and its derivatives.  
   
   
       14 . A complex according to  claim 13  wherein the complex is his bis(penicillinato)zinc.  
   
   
       15 . A complex according to  claim 13  wherein the complex is his bis(penicillinato)magnesium.  
   
   
       16 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of dimethylbiguanide and its derivatives.  
   
   
       17 . A complex according to  claim 16  wherein the complex is bis(dimethylbiguanido)zinc.  
   
   
       18 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of hydrochlorothiazide and its derivatives.  
   
   
       19 . A complex according to  claim 18  wherein the complex is bis(hydrochlorothiazido)zinc.  
   
   
       20 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of acycloguanosine and its derivatives.  
   
   
       21 . A complex according to  claim 19  wherein the complex is bis(acycloguanosinato)magnesium.  
   
   
       22 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of furosemide and its derivatives.  
   
   
       23 . A complex according to  claim 22  wherein the complex is bis(furosemidato)zinc.  
   
   
       24 . A complex according to  claim 22  wherein the complex is bis(furosemidato)magnesium.  
   
   
       25 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of DOPA and its derivatives.  
   
   
       26 . A complex according to  claim 25  wherein the complex is bis(DOPA)zinc.  
   
   
       27 . A complex according to  claim 25  wherein the complex is bis(DOPA)magnesium.  
   
   
       28 . A complex according to  claim 1  wherein the biologically active moiety is selected from the group consisting of alendronate and its derivatives.  
   
   
       29 . A complex according to  claim 28  wherein the complex is bis(alendronato)zinc.  
   
   
       30 . A complex according to  claim 28  wherein the complex is bis(alendronato)magnesium.  
   
   
       31 . A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety contains a β-diketone, ketophenol or β-ketoalcohol, functional group and 
 the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.    
   
   
       32 . A metal coordination complex of a biologically active moiety and a metal, wherein 
 the biologically active moiety contains an alcohol and an azole functional group, and    the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.    
   
   
       33 . A metal coordination complex of a biologically active moiety and a metal, wherein 
 the biologically active moiety contains a guanide or a diamine functional group, and    the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.    
   
   
       34 . A method of modulating the properties of a biologically active moiety comprising 
 forming a metal coordination complex with the biologically active moiety and a metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc, wherein    the biologically active moiety is selected from the group consisting of thyronine, tetracycline antibiotics, hydrocodone, oxycodone, and their derivatives, and    the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.    
   
   
       35 . A method of  claim 34  further comprising 
 adding an adjuvant selected from the group consisting of peptides, carbohydrates or lipids that confer desired performance parameters to the biologically active agent.    
   
   
       36 . The method of  claim 34 , wherein the properties to be modulated are selected from the group consisting of potency, stability, absorbability, targeted delivery, and combinations thereof.