Nutrient pharmaceutical formulation comprising polyphenols and use in treatment of cancer

Abstract

A nutrient pharmaceutical formulation composition useful for treating cancer comprising ascorbic acid, L-lysine, L-proline and at least one polyphenol compound selected from the group consisting of epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, catechin and the use of the composition in treating cancer and other tumors are provided. A nutrient pharmaceutical formulation composition of EPICAN FORTE™ and its method of use in treating cancer are also disclosed.

1 - 34 . (canceled)  
     
     
         35 . A nutrient pharmaceutical composition useful in treating cancer, comprising: 
 a) an ascorbic compound;    b) an amino acid combination consisting essentially of L-Lysine, L-proline, and N-acetyl cysteine; and    c) at least one polyphenol compound selected from the group consisting of epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, and catechin, wherein the compounds of a) and b) enhance the polyphenol compound's activity in blocking cancer proliferation and metastasis.    
     
     
         36 . The nutrient pharmaceutical composition of  claim 35 , wherein the ascorbic compound is selected from the group consisting of ascorbic acid, pharmaceutically acceptable ascorbate salts, ascorbate esters and/or mixture thereof.  
     
     
         37 . The nutrient composition of  claim 36 , wherein the pharmaceutically acceptable ascorbate salt is calcium ascorbate or magnesium ascorbate.  
     
     
         38 . The nutrient composition of  claim 36 , wherein the ascorbate ester is ascorbyl palmitate.  
     
     
         39 . The nutrient pharmaceutical composition of  claim 35 , wherein the lysine compound is selected from the group consisting of lysine hydrochloride and pharmaceutically acceptable lysine salts.  
     
     
         40 . The nutrient pharmaceutical composition of  claim 35 , wherein the proline compound is selected from the group consisting of proline hydrochloride and pharmaceutically acceptable proline salts.  
     
     
         41 . The nutrient pharmaceutical composition of  claim 35 , further comprising a trace element selected from the group consisting of selenium, copper, manganese, calcium and magnesium.  
     
     
         42 . The nutrient pharmaceutical composition of  claim 35 , further comprising an amino acid.  
     
     
         43 . The nutrient pharmaceutical composition of  claim 42 , wherein the amino acid is arginine.  
     
     
         44 . The nutrient pharmaceutical composition of  claim 35 , further comprising N-acetyl cysteine.  
     
     
         45 . A nutrient pharmaceutical composition useful in treating cancer, comprising: ascorbic acid, calcium ascorbate, magnesium ascorbate, ascorbyl palmitate, polyphenols, N-acetyl-cysteine, lysine, proline, arginine, selenium, copper, and manganese.  
     
     
         46 . The nutrient pharmaceutical composition of  claim 45 , wherein the composition comprises 250 mg ascorbic acid, 250 mg calcium ascorbate, 250 mg magnesium ascorbate, 250 mg ascorbyl palmitate, 1,000 mg polyphenols, 200 mg N-acetyl-cysteine, 1,000 mg lysine, 750 mg proline, 500 mg arginine, 30 mcg selenium, 2 mg copper, and 1 mg manganese.  
     
     
         47 . The nutrient pharmaceutical composition of  claim 45 , wherein the composition comprises 25 mg ascorbic acid, 25 mg calcium ascorbate, 25 mg magnesium ascorbate, 25 mg ascorbyl palmitate, 200 mg polyphenols, 10 mg N-acetyl-cysteine, 50 mg lysine, 25 mg proline, 50 mg arginine, 1 mcg selenium, 20 mcg copper, and 50 mcg manganese.  
     
     
         48 . The nutrient pharmaceutical composition of  claim 45 , wherein the composition comprises 5,000 mg ascorbic acid, 5,000 mg calcium ascorbate, 5,000 mg magnesium ascorbate, 5,000 mg ascorbyl palmitate, 5,000 mg polyphenols, 1,500 mg N-acetyl-cysteine, 5,000 mg lysine, 3,000 mg proline, 3,000 mg arginine, 200 mcg selenium, 9 mg copper, and 10 mg manganese.  
     
     
         49 . The nutrient pharmaceutical composition of  claim 45 , wherein the composition comprises 250 mg ascorbic acid, 250 mg calcium ascorbate, 250 mg magnesium ascorbate, 250 mg ascorbyl palmitate, 1,000 mg polyphenols, 200 mg N-acetyl-cysteine, 1,000 mg lysine, 750 mg proline, 500 mg arginine, 100 mcg selenium, 2 mg copper, 1 mg manganese, 500 mg calcium, and 400 mg magnesium.  
     
     
         50 . The nutrient pharmaceutical composition of  claim 45 , wherein the composition comprises 250 mg ascorbic acid, 250 mg calcium ascorbate, 250 mg magnesium ascorbate, 250 mg ascorbyl palmitate, 1,000 mg polyphenols, 200 mg N-acetyl-cysteine, 1,000 mg lysine, 750 mg proline, 500 mg arginine, 100 mcg selenium, 2 mg copper, 1 mg manganese, 500 mg calcium, 400 magnesium, and 200 citrus biofavonoids.  
     
     
         51 . A nutrient pharmaceutical composition useful in treating cancer, comprising: L-lysine, L-proline, L-arginine, ascorbic acid, calcium, magnesium, polyphenols, N-acetyl-cysteine, selenium, copper, and manganese.  
     
     
         52 . The nutrient pharmaceutical composition of  claim 51 , wherein the composition comprises 1,000 mg L-lysine, 750 mg L-proline, 500 mg L-arginine, 710 mg ascorbic acid, 22 mg calcium, 50 mg magnesium, 1000 mg polyphenols, 200 mg N-acetyl cysteine, 30 mcg selenium, 2 mg copper, and 1 mg manganese.  
     
     
         53 . The nutrient pharmaceutical composition of  claim 52 , wherein the ascorbic acid is selected from the group consisting of ascorbic acid, calcium ascorbate, magnesium ascorbate and ascorbyl palmitate.  
     
     
         54 . The nutrient pharmaceutical composition of  claim 52 , wherein the polyphenol is selected from the group consisting of epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, catechin and other pharmaceutically acceptable polyphenol salts and/or mixtures thereof.