1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or salt thereof

Abstract

To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof.

1 - 8 . (canceled)  
   
   
       9 . A method of antagonizing an arginine vasopressin receptor, comprising: contacting the arginine vasopressin receptor with a composition comprising: 
 a compound of formula (I) or a pharmaceutically acceptable salt thereof:                          wherein the ring D represents phenylene or pyridinediyl; X and Y may be the same or different and each represents CH or N; and R 1 , R 2  and R 3  may be the same or different and each represents a hydrogen atom, a hydroxyl group, a halogen, or a lower alkyl; and    a pharmaceutical carrier or excipient.    
   
   
       10 . The method of  claim 9 , wherein the ring D represents 1,4-phenylene, pyridine-2,5-diyl, or pyridine-3,6-diyl.  
   
   
       11 . The method of  claim 10 , wherein X and Y each represents CH, and R 1  represents a hydrogen atom.  
   
   
       12 . The method of  claim 11 , wherein the ring D represents 1,4-phenylene, and R 2  and R 3  each represents a hydrogen atom.  
   
   
       13 . The method of  claim 9 , wherein the compound is: 
 N-{4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,    N-{3-fluoro-4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,    2′-fluoro-N-{4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,    N{5-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]-2-pyridyl}biphenyl-2-carboxamide,    N-{6-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]-3-pyridyl}biphenyl-2-carboxamide, or    N-{2-hydroxy4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide.    
   
   
       14 . A method of treating heart failure or hyponatremia, comprising administering to a patient in need thereof a composition comprising: 
 a compound of formula (I) or a pharmaceutically acceptable salt thereof:                          wherein the ring D represents phenylene or pyridinediyl; X and Y may be the same or different and each represents CH or N; and R 1 , R 2  and R 3  may be the same or different and each represents a hydrogen atom, a hydroxyl group, a halogen, or a lower alkyl; and    a pharmaceutical carrier or excipient.    
   
   
       15 . The method of  claim 14 , wherein the ring D represents 1,4-phenylene, pyridine-2,5-diyl, or pyridine-3,6-diyl.  
   
   
       16 . The method of  claim 15 , wherein X and Y each represents CH, and R 1  represents a hydrogen atom.  
   
   
       17 . The method of  claim 16 , wherein the ring D represents 1,4-phenylene, and R 2  and R 3  each represents a hydrogen atom.  
   
   
       18 . The method of  claim 14 , wherein the compound is: 
 N-{4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,    N-{3-fluoro-4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,    2′-fluoro-N-{4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,    N-{5-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]-2-pyridyl}biphenyl-2-carboxamide,    N-{6-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]-3-pyridyl}biphenyl-2-carboxamide, or    N-{2-hydroxy-4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide.