DNA encoding MCK-10, a novel receptor tyrosine kinase

Abstract

The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of inhibiting MCK-10 activity. The invention relates to differentially spliced isoforms of MCK-10 and to other members of the MCK-10 receptor tyrosine kinase family. Genetically engineered host cells that express MCK-10 may be used to evaluate and screen drugs involved in MCK-10 activation and regulation. The invention relates to the use of such drugs, in the treatment of disorders, including cancer, by modulating the activity of MCK-10.

1 - 20 . (canceled)  
     
     
         21 . A monoclonal antibody which immunospecifically binds to an epitope of the MCK-10.  
     
     
         22 . The monoclonal antibody of  claim 21  which competitively inhibits the binding of ligand to the MCK-10.  
     
     
         23 . The monoclonal antibody of  claim 21  which is linked to a cytotoxic agent.  
     
     
         24 . The monoclonal antibody of  claim 21  which is liked to a radioisotope.  
     
     
         25 - 74 . (canceled)