Hemostatic dressing

Abstract

The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.

1 . A hemostatic dressing which comprises: 
 (i) a first fibrinogen layer;    (ii) a thrombin layer adjacent to said first fibrinogen layer; and    (iii) a second fibrinogen layer adjacent to said thrombin layer, wherein the thrombin layer is noncoextensive with the first fibrinogen layer and/or the second fibrinogen layer.    
   
   
       2 . A hemostatic dressing which comprises: 
 (i) a resorbable material layer;    (ii) a first fibrinogen layer adjacent to said resorbable material layer;    (iii) a thrombin layer adjacent to said first fibrinogen layer; and    (iv) a second fibrinogen layer adjacent to said thrombin layer, wherein the thrombin layer is noncoextensive with the first fibrinogen layer and/or the second fibrinogen layer.    
   
   
       3 . A hemostatic dressing which comprises: 
 (i) a first fibrinogen layer;    (ii) a resorbable material layer adjacent to said first fibrinogen layer;    (iii) a thrombin layer adjacent to said resorbable material layer; and    (iv) a second fibrinogen layer adjacent to said thrombin layer, wherein the thrombin layer is noncoextensive with the first fibrinogen layer and/or the second fibrinogen layer.    
   
   
       4 . The hemostatic dressing according to any one of claims  1 - 3 , wherein the thrombin layer is coextensive with 5% to 95% of the first fibrinogen layer.  
   
   
       5 . The hemostatic dressing of  claim 4 , wherein the thrombin layer is coextensive with 20 to 50% of the first fibrinogen layer.  
   
   
       6 . The hemostatic dressing according to any one of claims  1 - 3 , wherein the thrombin layer is coextensive with 5% to 95% of the second fibrinogen layer.  
   
   
       7 . The hemostatic dressing of  claim 6 , wherein the thrombin layer is coextensive with 20 to 50% of the first fibrinogen layer.  
   
   
       8 . The hemostatic dressing according to any one of claims  1 - 3 , wherein the thrombin layer is configured as an array of spots comprising thrombin.  
   
   
       9 . The hemostatic dressing according to any one of claims  1 - 3 , wherein the thrombin layer is configured as a single spot comprising thrombin.  
   
   
       10 . The hemostatic dressing according to any one of claims  1 - 3 , wherein the thrombin layer is configured as a plurality of lines comprising thrombin.  
   
   
       11 . The hemostatic dressing according to any one of claims  1 - 3 , further comprising a backing material.  
   
   
       12 . The hemostatic dressing of  claim 2 , wherein said resorbable material is selected from the group consisting of glycolic acid polymers, lactic acid polymers and glycolic acid/lactic acid co-polymers.  
   
   
       13 . The hemostatic dressing according to any one of claims  1 - 3 , wherein one or more of said layers comprises a solubilizing agent.  
   
   
       14 . The hemostatic dressing according to any one of claims  1 - 3 , wherein one or more of said layers comprises a filler.  
   
   
       15 . The hemostatic dressing according to any one of claims  1 - 3 , wherein one or more of said layers comprises a binding agent.  
   
   
       16 . A method of treating wounded tissue, which comprises applying to said wounded tissue a hemostatic dressing according to any one of claims  1 - 3 .  
   
   
       17 . The method of  claim 16 , further comprises hydrating said hemostatic dressing with a liquid that is exogenous to the wounded tissue.  
   
   
       18 . The method of  claim 16 , further comprising hydrating said hemostatic dressing with a liquid that is endogenous to the wounded tissue.  
   
   
       19 . A method for preparing a hemostatic dressing, the method comprising: 
 providing a first layer of fibrinogen;    applying a layer of thrombin to said first layer of fibrinogen; and    applying a second layer of fibrinogen to the layer of thrombin, wherein the layer of thrombin is noncoextensive with the first fibrinogen layer and/or the second fibrinogen layer.    
   
   
       20 . The method of  claim 19 , wherein the thrombin layer is coextensive with 5% to 95% of the first fibrinogen layer.  
   
   
       21 . The method of  claim 19 , wherein the thrombin layer is coextensive with 5% to 95% of the second fibrinogen layer.  
   
   
       22 . A method for preparing a hemostatic dressing, the method comprising: 
 providing a resorbable or nonresorbable backing layer having attached thereto a first layer of fibrinogen;    applying a layer of thrombin to said first layer of fibrinogen on a side of the fibrinogen layer that is opposite of the side to which the resorbable or nonresorbable backing layer is attached; and    applying a second layer of fibrinogen to the layer of thrombin, wherein the layer of thrombin is noncoextensive with the first fibrinogen layer and/or the second fibrinogen layer.    
   
   
       23 . The method of  claim 22 , wherein the thrombin layer is coextensive with 5% to 95% of the first fibrinogen layer.  
   
   
       24 . The method of  claim 22 , wherein the thrombin layer is coextensive with 5% to 95% of the second fibrinogen layer.