Intra-aneurysm devices

Abstract

Devices for occluding an aneurysm are provided. In particular, the device include an upper member that sits against the dome of the aneurysm, a lower member that sits in the neck of the aneurysm, and a means of adjusting the overall dimensions of the device. Also provided are methods of making and using these devices.

1 . A vaso-occlusive device for placement within an aneurysm having a neck and a dome, the device comprising 
 a lower member having a linear configuration prior to deployment and a deployed open configuration, wherein the deployed configuration bridges the neck of the aneurysm;    an upper member having a undeployed, linear configuration prior and an open, deployed configuration, wherein the deployed configuration rests against at least a portion of the dome of the aneurysm, and    a means of adjusting the overall dimensions of the device.    
     
     
         2 . The device of  claim 1 , wherein the distance between the upper and lower members is adjustable.  
     
     
         3 . The device of  claim 1 , wherein the upper and lower members are contiguous.  
     
     
         4 . The device of  claim 1 , wherein one or both of the upper member and lower member are compressible.  
     
     
         5 . The device of  claim 1 , wherein the upper and lower members are separate, the device further comprising an adjustable central member having a proximal end connected to the lower member and distal end connected to the upper member.  
     
     
         6 . The device of  claim 5 , wherein the central member comprises a compressible element.  
     
     
         7 . The device of  claim 5 , wherein the central member comprises an extendable member connected to the upper member.  
     
     
         8 . The device of  claim 5 , wherein the central member comprises an expandable element.  
     
     
         9 . The device of  claim 1 , wherein the upper member comprises a plurality of axially moveable wires passing through the lumen of the central member, each wire comprising a distal end and a proximal end.  
     
     
         10 . The device of  claim 9 , wherein the distal end of one or more of the wires is attached to the central member.  
     
     
         11 . The device of  claim 9 , wherein the distal end of one or more of the wires is attached to the lower member.  
     
     
         12 . The device of  claim 1 , wherein the lower and/or upper members comprise a braid configuration.  
     
     
         13 . The device of  claim 1 , wherein the upper and lower members are contiguous.  
     
     
         14 . The device of  claim 1 , further comprising one or more detachment junctions.  
     
     
         15 . The device of  claim 14 , wherein at least one detachment junction comprises an electrolytically detachable end adapted to detach by imposition of a current thereon.  
     
     
         16 . The device of  claim 14 , comprising a detachment junction positioned between the upper member and a pusher wire and one or more detachment junctions positioned between the lower member and a pusher tube.  
     
     
         17 . The device of  claim 1 , further comprising one or more locking mechanisms.  
     
     
         18 . The device of  claim 17 , wherein the locking mechanism comprises an expandable material.  
     
     
         19 . The device of  claim 17 , wherein the locking mechanism comprises a self-expanding element.  
     
     
         20 . The device of  claim 1 , wherein the upper member comprises a metal.  
     
     
         21 . The device of  claim 20 , wherein the metal is selected from the group consisting of nickel, titanium, platinum, gold, tungsten, iridium and alloys or combinations thereof.  
     
     
         22 . The device of  claim 21 , wherein the alloy is nitinol.  
     
     
         23 . The device of  claim 1 , wherein the lower member comprises a metal selected from the group consisting of platinum, palladium, rhodium, gold, tungsten and alloys thereof.  
     
     
         24 . The device of  claim 23 , wherein the lower member comprises nitinol.  
     
     
         25 . The device of  claim 23 , wherein the lower member comprises a mesh or braid structure.  
     
     
         26 . The device of  claim 1 , wherein the lower member comprises a film.  
     
     
         27 . The device of  claim 26 , wherein the film is selected from the group consisting of a porous film, a polymer film and a metallic film.  
     
     
         28 . The device of  claim 1 , further comprising an additional component.  
     
     
         29 . The device of  claim 28 , wherein the additional component is bioactive.  
     
     
         30 . A method of occluding a body cavity comprising introducing a vaso-occlusive device according to  claim 1  into the body cavity.  
     
     
         31 . The method of  claim 29 , wherein the body cavity is an aneurysm.