Nitrogen-containing aromatic derivatives

Abstract

Compounds represented by the following general formula: [wherein A g is an optionally substituted 5- to 14-membered heterocyclic group, etc.; X g is —O—, —S—, etc.; Y g is an optionally substituted C 6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and T g1 is a group represented by the following general formula: (wherein E g is a single bond or —N(R g2 )—, R g1 and R g2 each independently represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, etc. and Z g represents a C 1-8 alkyl group, a C 3-8 alicyclic hydrocarbon group, a C 6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.

1 .- 42 . (canceled)  
     
     
         43 . A process for preparing a compound represented by the formula:  
       
         
           
           
               
               
           
         
         a pharmacologically acceptable salt or hydrate thereof wherein:  
         R 1  and R 2  are each independently a hydrogen atom, an optionally substituted C 1-6  alkyl group, an optionally substituted C 2-6  alkenyl group, an optionally substituted C 2-6  alkynyl group, an optionally substituted C 3-8  alicyclic hydrocarbon group, an optionally substituted C 2-7  acyl group or an optionally substituted C 2-7  alkoxycarbonyl group;  
         Z 12  is a hydrogen atom, an optionally substituted C 1-6  alkyl group, an optionally substituted C 2-6  alkenyl group, an optionally substituted C 2-6  alkynyl group, an optionally substituted C 3-8  alicyclic hydrocarbon group, an optionally substituted C 6-14  aryl group, an optionally substituted 5- to 14-membered heterocyclic group, an optionally substituted 5- to 14-membered aromatic heterocyclic group or a group represented by the formula:  
         
           
             
             
                 
                 
             
           
           wherein Z 31 , Z 33  and Z 34  are each independently a methylene group, —CO—, —NH— or —O—, and Z 32  is a single bond, a methylene group, —CO—, —NH— or —O—; and  
           wherein Z 12  is not pyrazolyl;  
         
         R 300  and R 301  are each independently a hydrogen atom, a halogen atom, a cyano group, a nitro group, an amino group, an optionally substituted C 1-6  alkyl group, an optionally substituted C 3-8  alicyclic hydrocarbon group, an optionally substituted C 1-6  alkoxy group, an optionally substituted C 2-7  alkoxycarbonyl group, a formyl group, a group represented by the formula  
         
           
             
             
                 
                 
             
           
           wherein V 300  and V 301  are each independently a hydrogen atom or an optionally substituted C 1-6  alkyl group, or an optionally substituted C 2-7  acyl group;  
         
         R a11  is a group represented by the formula -V a21 -V a22 -V a23 , wherein: 
 V a21  is an optionally substituted C 1-6  alkylene group, a single bond or a group represented by the formula:  
                     
 V a22  is a single bond, an oxygen atom, a sulfur atom, —CO—, —SO—, —SO 2 —, —CONR a14 —, —SO 2 NR a14 —, —NR a14 SO 2 —, —NR a14 CO— or —NR a14 —; 
 wherein R a14  is a hydrogen atom, an optionally substituted C 1-6  alkyl group or an optionally substituted C 3-8  alicyclic hydrocarbon group; and  
 
 V a23  is a hydrogen atom, an optionally substituted C 1-6  alkyl group, an optionally substituted C 2-6  alkenyl group, an optionally substituted C 2-6  alkynyl group, an optionally substituted C 3-8  alicyclic hydrocarbon group, an optionally substituted C 6-14  aryl group, an optionally substituted 5- to 14-membered heterocyclic group or an optionally substituted 5- to 14-membered aromatic heterocyclic group; and  
 
         R a12  is a cyano group or a group represented by the formula:  
         
           
             
             
                 
                 
             
           
           wherein:  
           V a11  is —CO— or —SO 2 —; and  
           V a12 , V a13  and V a14  are each independently a hydrogen atom, an optionally substituted C 1     —     6  alkyl group, an optionally substituted C 2-6  alkenyl group, an optionally substituted C 2-6  alkynyl group, an optionally substituted C 3-8  alicyclic hydrocarbon group, an optionally substituted C 6-14  aryl group, an optionally substituted 5- to 14-membered heterocyclic group or an optionally substituted 5- to 14-membered aromatic heterocyclic group,  
         
         which comprises reacting a compound represented by the formula:  
         
           
             
             
                 
                 
             
           
         
         with a compound represented by the formula:  
         
           
             
             
                 
                 
             
           
         
       
     
     
         44 . The process according to  claim 43 , further comprising the step of adding a base.