Thermolabile liposome with a controlled release temperature

Abstract

The invention relates to a thermolabile liposome with a controlled release temperature for the liposome content, in particular a liposome which is stable at 37° C. in serum and with a controlled release temperature of between 40 and 80° C.

1 - 8 . (canceled)  
   
   
       9 . A thermolabile liposome having a controlled release temperature for the liposome content, wherein said thermolabile liposome comprises at least one phosphatidylcholine with a main transition temperature in the range from 0 to 80° C. and more than 15 to 70% by weight of phosphatidyl-oligoglycerol.  
   
   
       10 . The liposome as claimed in  claim 9 , said at least one phosphatidylcholine is selected from the group consisting of 1-palmitoyl-2-olioylglycero-3-phosphocholine, 1-stearoyl-2-olioyl-3-phosphocholine, 1-palmitoyl-2-lauroyl-glycero-3-phosphocholine, 1-behenoyl-2-olioyl-glycero-3-phosphocholine, 1-stearoyl-2-lauroyl-glycero-3-phosphocholine, 1,3-dimyristoylglycero-2-phosphocholine, 1,2-dimyristoylglycero-3-phosphocholine, 1-palmitoyl-2-myristoylglycero-3-phosphocholine, 1-stearoyl-2-myristoylglycero-3-phosphocholine, 1-myristoyl-2-palmitoylglycero-3-phosphocholine, 1,3-palmitoylglycero-2-phospho-choline, 1,2-dipalmitoylglycero-3-phosphocholine, 1-myristoyl-2-stearoylglycero-3-phosphocholine, 1-stearoyl-3-myristoylglycero-2-phosphocholine, 1-stearoyl-2-palmitoylglycero-3-phosphocholine, 1-palmitoyl-2-stearoylglycero-3-phosphocholine, 1,3-distearoylglycero-2-phosphocholine, 1,2-di-stearoylglycero-3-phosphocholine, 1,2-di-arachinoylglycero-3-phosphocholine, 1,2-di-behenoylglycero-3-phosphocholine and 1,2-di-lignoceroylglycero-3-phosphocholine.  
   
   
       11 . The liposome as claimed in  claim 9 , wherein said phosphatidyloligoglycerol is dipalmitoylphosphoglyceroglycerol.  
   
   
       12 . The liposome as claimed in  claim 9  comprising 20 to 75% of dipalmitoyllecithin (DPPC), 10 to 25% of distearoyllecithin (DSPC) and more than 15 to 50% of dipalmitoylphosphoglyceroglycerol (DPPG2).  
   
   
       13 . The liposome as claimed in  claim 9 , further comprising up to 15% of at least one alkylphosphocholine.  
   
   
       14 . The liposome as claimed in  claim 13 , comprising 10 to 15% of at least one of hexadecylphosphocholine, oleoyl-phosphocholine or ether lysolecithin.  
   
   
       15 . The liposome as claimed in  claim 9 , wherein it contains no cholesterol.  
   
   
       16 . The liposome as claimed in  claim 9 , further comprising an active compound or a labelling substance.  
   
   
       17 . The liposome as claimed in  claim 10 , wherein said phosphatidyloligoglycerol is dipalmitoylphosphoglyceroglycerol.  
   
   
       18 . The liposome as claimed in  claim 9 , wherein the liposome consists essentially of said at least one phosphatidylcholine.