Composition comprising scutellaria baicalensis and their uses thereof

Abstract

This invention described various formula composite of Scutellaria baicalensis for various diseases and conditions. The formula takes the advantage of our recent discovery of Scutellaria baicalensis can inhibit cyclooxygenase-2 (COX-2) activity and expression, resulting in decrease of prostaglandin synthesis. COX-2 is involved in many biological processes, such as inflammation, pain, carcinogenesis, etc. Combination of Scutellaria baicalensis with lycopene can be used for cancer prevention, especially smoking induced. Combination of Scutellaria baicalensis with glucosamine and chondroitin can be used for arthritis. Finally, this invention disclosed various method to prepare this formula and composition.

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       14 . A composition formulated by extracting a therapeutically effective amount of  Scutellaria baicalensis.    
   
   
       15 . The composition of  claim 14 , wherein the composition is capable of treating cancer.  
   
   
       16 . The composition of  claim 14 , wherein the composition is capable of preventing cancer.  
   
   
       17 . The composition of  claim 14 , further comprising a therapeutically effective amount of glucosamine and chondroitin.  
   
   
       18 . The composition of  claim 17 , wherein the composition comprises 20 to 40%  Scutellaria baicalensis.    
   
   
       19 . The composition of  claim 17 , wherein the composition comprises about 34%  Scutellaria baicalensis.    
   
   
       20 . The composition of  claim 17 , wherein the composition comprises 30 to 60% glucosamine.  
   
   
       21 . The composition of  claim 17 , wherein the composition comprises about 52% glucosamine.  
   
   
       21 . The composition of  claim 17 , wherein the composition comprises 10 to 20% chondroitin.  
   
   
       22 . The composition of  claim 17 , wherein the composition comprises about 14% chondroitin.  
   
   
       23 . The composition of  claim 17 , wherein the composition is capable of treating arthritis.  
   
   
       24 . The composition of  claim 17 , wherein the composition is capable of preventing arthritis.  
   
   
       25 . The composition of  claim 23 , wherein the arthritis comprises rheumatoid arthritis and osteoarthritis.  
   
   
       26 . A method of treating a subject comprising administering an effective amount of the composition of  claim 1 .  
   
   
       27 . A method of treating a subject comprising administering an effective amount of the composition of  claim 4 .  
   
   
       28 . A method for determining  Scutellaria baicalensis  batch variation, the method comprising: 
 determining physical characteristics of the  Scutellaria baicalensis  batch; and    determining biological activity of the  Scutellaria baicalensis  batch.    
   
   
       29 . The method of  claim 28 , wherein determining the physical characteristics comprises using high pressure chromatography.  
   
   
       30 . A method for forming the composition of  claim 1  comprising performing an extraction of  Scutellaria baicalensis.    
   
   
       31 . The method of  claim 30 , further comprising combining the  Scutellaria baicalensis  extract with glucosamine and chondroitin.