US2006172353A1PendingUtilityA1

Diagnosis of candidiasis and candidemia or invasive candida infection

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Assignee: MATTSBY-BALTZER INGERPriority: Oct 21, 2002Filed: Oct 21, 2003Published: Aug 3, 2006
Est. expiryOct 21, 2022(expired)· nominal 20-yr term from priority
Inventors:Inger Mattsby-BaltzerNahid Kondori
G01N 33/56961
36
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Claims

Abstract

The use of an antibody to a C albicans cell wall antigen or to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of C albicans , or preferably a combination of an IgG2 antibody to a phosphopeptidomannan (PPM) fraction of the cell wall of C albicans , and an IgG1 or IgG3 antibody to a C albicans cell wall antigen in the diagnosis of candidiasis or invasive candidiasis is disclosed. Also diagnostic tests are disclosed.

Claims

exact text as granted — not AI-modified
1 . A method for the diagnosis of candidiasis or invasive candidiasis comprising assaying with a combination of an IgG2 antibody to a phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , and an IgG1 antibody to a  C albicans  cell wall antigen, and glucan.  
   
   
       2 . A method for the diagnosis of candidiasis or invasive candidiasis comprising assaying with an antibody to a  C albicans  cell wall antigen or to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans.    
   
   
       3 . A method according to  claim 2 , wherein said antibody is an IgG2 antibody.  
   
   
       4 . A method according to  claim 2 , wherein said antibody is an IgG1 antibody.  
   
   
       5 . A method according to  claim 2 , wherein said antibody is an IgG3 antibody.  
   
   
       6 . Diagnostic kit for the diagnosis of candidiasis or invasive candidiasis comprising 
 means for drawing a sample from a patient;    means for an assay for the detection of a combination of an IgG2 antibody to a phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , and an IgG1 antibody to a  C albicans  cell wall antigen, and glucan, wherein said sample is analyzed for the presence of the simultaneous presence of an IgG2 antibody to a phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , and an IgG1 antibody to a  C albicans  cell wall antigen, and glucan.    
   
   
       7 . The diagnostic kit according to  claim 6 , wherein said assay is a sandwich ELISA assay.  
   
   
       8 . Diagnostic kit for the diagnosis of candidiasis or invasive candidiasis comprising 
 means for drawing a sample from a patient;    means for an assay for the detection of an antibody to a  C albicans  cell wall antigen or to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , wherein said sample is analyzed for the presence of an antibody to a  C albicans  cell wall antigen or to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans.      
   
   
       9 . The diagnostic kit according to  claim 8 , wherein said antibody is an IgG2 antibody.  
   
   
       10 . The diagnostic kit according to  claim 8 , wherein said antibody is an IgG1 antibody.  
   
   
       11 . The diagnostic kit according to  claim 8 , wherein said antibody is an IgG3 antibody.  
   
   
       12 . The diagnostic kit according to  claim 8 , wherein said assay is a sandwich ELISA assay.  
   
   
       13 . A method for diagnosing candidiasis or invasive candidiasis in a patient comprising 
 drawing a sample from the patient, and    performing an assay for the detection of an IgG2 antibody to a phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , and an IgG1 antibody to a  C albicans  cell wall antigen, and glucan, wherein the simultaneous presence of an IgG2 antibody to a phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , and an IgG1 antibody to a  C albicans  cell wall antigen, and glucan indicates candidiasis or invasive candidiasis in the patient.    
   
   
       14 . A method for diagnosing candidiasis or invasive candidiasis in a patient comprising 
 drawing a sample from the patient, and    performing an assay for the detection of an antibody to a  C albicans  cell wall antigen or to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , wherein the presence of an antibody to a  C albicans  cell wall antigen or to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans  indicates candidiasis or invasive candidiasis in the patient.    
   
   
       15 . A method for the diagnosis of candidemia or invasive  Candida  infection comprising assaying with an antibody.  
   
   
       16 . A method according to  claim 15 , wherein said antibody is an IgG antibody to a native cell wall fragment of  C albicans.    
   
   
       17 . A method according to  claim 15 , wherein said antibody is an IgG antibody to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans.    
   
   
       18 . A method according to  claim 16 , wherein said IgG antibody is a human serum IgG antibody.  
   
   
       19 . Diagnostic kit for the diagnosis of candidemia or invasive  Candida  infection comprising 
 means for drawing a sample from a patient;    means for an assay for the detection of an IgG antibody to a native cell wall fragment of  C albicans  or an IgG antibody to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , wherein said sample is analyzed for the presence of an IgG antibody to a native cell wall fragment of  C albicans  or an IgG antibody to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans.      
   
   
       20 . The diagnostic kit according to  claim 19 , wherein said assay is a sandwich ELISA assay.  
   
   
       21 . The diagnostic kit according to  claim 19 , wherein said antibody is a human serum IgG antibody.  
   
   
       22 . A method for diagnosing candidemia or invasive  Candida  infection in a patient comprising 
 drawing a sample from the patient, and    performing an assay for the detection of an IgG antibody to a native cell wall fragment of  C albicans  or an IgG antibody to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans , wherein the presence of an IgG antibody to a native cell wall fragment of  C albicans  or an IgG antibody to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of  C albicans  indicates candidemia or invasive  Candida  infection in the patient.    
   
   
       23 . The method according to  claim 22 , wherein said antibody is a human serum IgG antibody.  
   
   
       24 . The diagnostic kit according to  claim 9 , wherein said assay is a sandwich ELISA assay.  
   
   
       25 . The diagnostic kit according to  claim 10 , wherein said assay is a sandwich ELISA assay.  
   
   
       26 . The diagnostic kit according to  claim 11 , wherein said assay is a sandwich ELISA assay.  
   
   
       27 . A method according to  claim 17 , wherein said IgG antibody is a human serum IgG antibody.  
   
   
       28 . The diagnostic kit according to  claim 20 , wherein said antibody is a human serum IgG antibody.

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