Stent with coatings containing self-assembled monolayers

Abstract

A medical device with a coating, particularly a drug eluting stent, is described. The coating includes a self-assembled monolayer.

1 . An implantable medical device comprising a coating, the coating including a polymeric layer disposed on at least a portion of an implantable medical device, and a self-assembled monolayer of molecules of an organic or elemento-organic substance disposed on the polymeric layer.  
     
     
         2 . The device of  claim 1 , wherein the device is a stent.  
     
     
         3 . The device of  claim 1 , wherein the self-assembled monolayer is chemically bonded to the polymeric layer.  
     
     
         4 . The device of  claim 1 , further comprising a therapeutic substance incorporated in the coating.  
     
     
         5 . The device of  claim 4 , wherein the therapeutic substance is rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, or 40-O-tetrazole-rapamycin.  
     
     
         6 . The device of  claim 1 , wherein the self-assembled monolayer is prepared out of a substance having a methylene-based chain or a silicone-based chain.  
     
     
         7 . The device of  claim 6 , wherein the substance further includes at least one reactive substitutent.  
     
     
         8 . The device of  claim 7 , wherein the reactive substitutent is selected from a group consisting of hydroxyl, carboxyl, vinyl, anhydride, acyl chloride, sulfonyl, isocyanate, epoxy, amino, thiol, and acrylic.  
     
     
         9 . The device of  claim 1 , further comprising a biocompatible agent chemically bonded to the self-assembled monolayer.  
     
     
         10 . The device of  claim 9 , wherein the biocompatible agent is selected from a group consisting of polypeptides, heparin, hyaluronic acid, and superoxide dismutase mimics.  
     
     
         11 . The device of  claim 1 , wherein the polymer of the polymeric layer includes at least one reactive substitutent.  
     
     
         12 . The device of  claim 11 , wherein the reactive substitutent is selected from a group consisting of hydroxyl, amino, aldehyde, and isocyanate.