US2006182814A1PendingUtilityA1
Biochemically balanced peritoneal dialysis solutions
Est. expiryJul 1, 2014(expired)· nominal 20-yr term from priority
A61P 7/08A61P 3/00A61M 1/287A61P 13/12A61K 33/14A61K 33/00A61K 45/06
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Claims
Abstract
A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g. pH of 70 to 74 and contains bicarbonate at a concentration that is found in normal blood. Additionally, the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in normal blood. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.
Claims
exact text as granted — not AI-modified1 . A peritoneal dialysis solution including bicarbonate at a level of less than or equal to 30 mM/L, having a carbon dioxide partial pressure that is less than 60 mmHg and including at least one weak acid selected from the group consisting of: lactate; pyruvate; citrate; isocitrate; cis-aconitase; α-ketoglutarate; succinate; fumarate; malate; and oxaloacetate.
2 . The peritoneal dialysis solution of claim 1 wherein bicarbonate is present in the solution at 25 mM/L.
3 . The peritoneal dialysis solution of claim 1 wherein the weak acid is present in an amount comprising approximately 10 mEq/L to about 20 mEq/L.
4 . The peritoneal dialysis solution of claim 1 wherein the carbon dioxide partial pressure of the solution is approximately the same as the carbon dioxide partial pressure of blood.
5 . The peritoneal dialysis solution of claim 1 wherein the solution has a pH of approximately 7.0 to about 7.4.
6 . The peritoneal dialysis solution of claim 1 wherein the weak acids have a pKa of <5.0.
7 . The peritoneal dialysis solution of claim 1 wherein the carbon dioxide partial pressure of the solution is approximately the same as the carbon dioxide partial pressure of blood.
8 . A peritoneal dialysis solution comprising:
Dextrose (hydrous) (g/dl)
1.5-4.25
Sodium (mEq/L)
100-140
Chloride (mEq/L)
70-110
Calcium (mEq/L)
0.0-4.0
Magnesium (mEq/L)
0.0-4.0
Bicarbonate (mEq/L)
20.0-30.0
Weak acid (mEq/L)
10.0-20.0
wherein the weak acid is at least one acid chosen from the group consisting of: lactate; pyruvate; citrate; isocitrate; cis-aconitase; α-ketoglutarate; succinate; fumarate; malate; and oxaloacetate.
9 . The peritoneal dialysis solution of claim 8 wherein the solution has a pH of approximately 7.0 to about 7.4.
10 . The peritoneal dialysis solution of claim 8 wherein the weak acids have a pKa of <5.0.
11 . The peritoneal dialysis solution of claim 8 wherein the carbon dioxide partial pressure is less than 60 mmHg.
12 . The peritoneal dialysis solution of claim 8 wherein the carbon dioxide partial pressure of the solution is approximately the same as the carbon dioxide partial pressure of normal blood.
13 . A peritoneal dialysis solution comprising:
Dextrose (hydrous) (g/dl)
1.5-4.25
Sodium (mEq/L)
100-140
Chloride (mEq/L)
70-110
Calcium (mEq/L)
0.0-4.0
Magnesium (mEq/L)
0.0-4.0
Bicarbonate (mEq/L)
20.0-30.0
Weak acid (mEq/L)
10.0-20.0
wherein the weak acid is at least one acid chosen from the group consisting of: lactate; pyruvate; citrate; isocitrate; cis-aconitase; α-ketoglutarate; succinate; fumarate; malate; and oxaloacetate; and
the solution has a carbon dioxide partial pressure that is substantially similar to the carbon dioxide partial pressure of a normal subject's blood and the solution has a pH of7.0 to 7.4.
14 . A method for correcting metabolic acidosis in a dialysis patient suffering or likely to suffer from same comprising the step of:
administering to a patient a peritoneal dialysis solution that has a bicarbonate level and carbon dioxide partial pressure that are substantially similar to that found in the patient's blood.
15 . The method of claim 14 wherein the solution comprises:
Dextrose (hydrous) (g/dl)
1.5-4.25
Sodium (mEq/L)
100-140
Chloride (mEq/L)
70-110
Calcium (mEq/L)
0.0-4.0
Magnesium (mEq/L)
0.0-4.0
Bicarbonate (mEq/L)
20.0-30.0
Weak acid (mEq/L)
10.0-20.0
16 . The method of claim 14 including the step of administering to the patient a weak acid that is present in the solution in an amount that offsets the daily hydrogen production of approximately 1 mEq/kg/day.
17 . The method of claim 16 wherein the weak acids have a pKa of <5.0.
18 . The method of claim 15 wherein the solution has a pH of approximately 7.0 to about 7.4.
19 . The method of claim 14 wherein the solution does not include lactate.
20 . The method of claim 16 wherein the weak acid is present in the solution at a level of approximately 10 to about 20 mEq/L.Cited by (0)
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