Methods of treating dry eye disorders

Abstract

Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.

1 - 7 . (canceled)  
   
   
       8 . A method for the treatment of dry eye which comprises administering to a mammal a composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a c-jun N-terminal kinase inhibitor.  
   
   
       9 . The method of  claim 8  wherein the pharmaceutically effective amount of the c-jun N-terminal kinase inhibitor is 0.001-1.0% (w/w).  
   
   
       10 . The method of  claim 8  wherein the composition is topically administered to the eye.  
   
   
       11 . The method of  claim 8  wherein the dry eye is associated with refractive surgery.