US2006189793A1PendingUtilityA1

Methods and compositions for inhibiting neoplastic cell growth

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Assignee: SERONO GENETICS INST SAPriority: Dec 22, 1998Filed: Apr 27, 2006Published: Aug 24, 2006
Est. expiryDec 22, 2018(expired)· nominal 20-yr term from priority
Inventors:Frances YenBlake DenisonAymeric DuclertLydie BougueleretCatherine CluselJean-Baptiste Dumas Milne-EdwardsBernard BihainBarbara BourDana Ebbets-ReedLuisa Salter-Cid
A01K 2217/05A61K 38/00A01K 2217/075C07K 14/4747C07K 16/30C07K 2319/02C07K 14/47C12N 15/625C07K 2319/32C07K 2319/21
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Claims

Abstract

The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptdes. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.

Claims

exact text as granted — not AI-modified
1 . An isolated antibody that specifically binds to a polypeptide comprising SEQ ID NO: 3.  
     
     
         2 . The isolated antibody according to  claim 1 , wherein said antibody is a whole antibody or an antigen binding fragment thereof.  
     
     
         3 . The isolated antibody according to  claim 2 , wherein said antigen binding fragment is an Fab, Fab′, F(ab) 2 , F(ab′) 2 , Fd, single chain Fvs (scFv), single-chain antibody, or a disulfide-linked Fvs.  
     
     
         4 . The antibody according to  claim 1 , wherein said antibody is polyclonal.  
     
     
         5 . The isolated antibody according to  claim 1 , wherein said antibody is monoclonal.  
     
     
         6 . The isolated antibody according to  claim 1 , wherein said antibody is multispecific.  
     
     
         7 . The isolated antibody according to  claim 1 , wherein said antibody is labeled.  
     
     
         8 . The isolated antibody according to  claim 2 , wherein said antibody is labeled.  
     
     
         9 . The isolated antibody according to  claim 3 , wherein said antibody is labeled.  
     
     
         10 . The isolated antibody according to  claim 4 , wherein said antibody is labeled.  
     
     
         11 . The isolated antibody according to  claim 5 , wherein said antibody is labeled.  
     
     
         12 . The isolated antibody according to  claim 6 , wherein said antibody is labeled.

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