US2006193904A1PendingUtilityA1

Liposome loading with metal ions

61
Assignee: TARDI PAULPriority: Oct 3, 2001Filed: Oct 21, 2005Published: Aug 31, 2006
Est. expiryOct 3, 2021(expired)· nominal 20-yr term from priority
Inventors:Paul TardiSharon JohnstoneMurray WebbMarcel BallySheela Abraham
A61K 9/1272A61K 31/7072A61K 31/7048A61K 45/06A61P 35/00A61K 31/7076A61K 31/704A61P 43/00A61K 31/00A61K 9/1271A61K 9/127A61K 31/4745A61K 33/243
61
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

This invention relates to encapsulation of drugs and other agents into liposomes.

Claims

exact text as granted — not AI-modified
1 . A composition comprising liposomes containing an internal solution, the internal solution comprising one or more encapsulated transition metal ions and one or more encapsulated therapeutic agents, provided that if the one or more therapeutic agents is solely doxorubicin, the one or more encapsulated metal ions is not solely manganese, wherein the liposomes do not comprise an ionophore.  
     
     
         2 . The composition of  claim 1 , wherein the internal solution comprises a metal compatible solution.  
     
     
         3 . (canceled)  
     
     
         4 . The composition of  claim 1 , further comprising in an external solution to the liposome.  
     
     
         5 . The composition of  claim 4 , wherein the external solution and external surfaces of the liposomes contain substantially no uncomplexed metal ions.  
     
     
         6 . The composition of  claim 5 , wherein the external solution comprises a metal chelating agent.  
     
     
         7 . The composition of  claim 4 , wherein the external solution and the internal solution have substantially the same pH.  
     
     
         8 . The composition of  claim 1 , wherein the liposomes are of low cholesterol.  
     
     
         9 . The composition of  claim 1 , wherein the one or more metal ions are first transition series metal ions.  
     
     
         10 . The composition of  claim 1 , wherein the one or more metal ions are selected from the group consisting of: Fe, Co, Ni, Cu, Zn, V, Ti, Cr, Rh, Ru, Mo, and Pd ions.  
     
     
         11 . The composition of  claim 1 , wherein the one or more metal ions are selected from the group consisting of: Fe, Co, Cu and Zn ions.  
     
     
         12 . The composition of  claim 1 , wherein the one or more metal ions are selected from the group consisting of: Zn, Co, and Cu ions.  
     
     
         13 . The composition of  claim 1 , wherein the one or more metal ions comprise Cu ions.  
     
     
         14 . The composition of  claim 10 , wherein the internal solution further comprises Mn ions.  
     
     
         15 . The composition of  claim 1 , wherein the pH of the internal solution is in the range of about 6.0 to about 8.5.  
     
     
         16 . The composition of  claim 1 , wherein the liposomes comprise one or more lipids that are negatively charged at physiological pH.  
     
     
         17 . The composition of  claim 16 , wherein the one or more negatively charged lipids are selected from PG and PI.  
     
     
         18 . The composition of  claim 1 , wherein the therapeutic agent is an antineoplastic agent.  
     
     
         19 - 43 . (canceled)

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.