Combinations of vasoactive agents and their use in the treatment of sexual dysfunctions

Abstract

This invention relates to combinations of vasoactive substances which are useful in the treatment of sexual dysfunctions associated with poor local blood supply and/or insufficient lubrication. The active compounds are selected from a:—esculoside or visnadine;—forskolin or extracts containing it, or alternatively, purified lipophilic extracts of plants of the genus Ipomea ;—esters of ximenynic acid;—optionally, at least one compound selected from a icarin or derivatives or extracts thereof which contain it, amentoflavone, and Gingko biloba dimeric flavones. The combination of these vasoactive substances is incorporated in gels and lotions designed to be applied to the genital organs. These formulations are useful in inducing erection of the male and female sex organs and enhancing orgasm and sexual performance. The formulations are particularly useful in the treatment of female sexual dysfunctions.

1 . Topical compositions containing: 
 esculoside or visnadine;    forskolin or extracts containing it, or alternatively, purified lip ophilic extracts of plants of the genus  Ipomea;      esters of ximenynic acid;    optionally, at least one compound selected from icarin or derivatives or extracts thereof which contain it, amentoflavone, and  Gingko biloba  dimeric flavones.    
   
   
       2 . Compositions as claimed in  claim 1 , wherein icarin derivatives comprise 7-hydroxyethyl-7-desgluco-icarin, 7-hydroxyethyl-icarin, 7-aminoethyl-icarin, 7-hydroxyethyl-3-0-rhamnosyl-icarin, 7-amino ethyl-3-rhamnosyl-icarin, 8-dihydro-icarin or its glycosides in 7 and 3.  
   
   
       3 . Compositions as claimed in  claim 1 , wherein  Gingko biloba  dimeric flavones comprise amentoflavone.  
   
   
       4 . Compositions as claimed in  claim 1 , wherein the ximenynic acid ester is the ethyl ester.  
   
   
       5 . Compositions as claimed in  claim 1  containing Visnadine,  Coleus forskolii  purified extract, ximenynic acid ethyl ester, lubricants and anti-irritant excipients.  
   
   
       6 . Compositions as claimed in  claim 1  containing esculoside,  Coleus forskolii  purified extract, ximenynic acid ethyl ester.  
   
   
       7 . Compositions as claimed in  claim 1  containing Visnadine, Forskolin e ethyl ximenynate.  
   
   
       8 . Compositions as claimed in  claim 1  wherein the purified extracts of  Ipomea  plants are selected from  Ipomea hederacea, Ipomea parassitica, Ipomea batatas.    
   
   
       9 . The use of a combination of: 
 esculoside or visnadine;    forskolin or extracts containing it, or alternatively, purified lipophilic extracts of plants of the genus  Ipomea;      esters of ximenynic acid;    optionally, at least one compound selected from a icarin or derivatives or extracts thereof which contain it, amentoflavone, and  Gingko biloba  dimeric flavones;    for the preparation of compositions for the topical treatment of sexual dysfunctions.