27411, a novel human PGP synthase

Abstract

The present invention relates to a newly identified human PGP synthase. The invention also relates to polynucleotides encoding the PGP synthase. The invention further relates to methods using the PGP synthase polypeptides and polynucleotides as a target for diagnosis and treatment in PGP synthase-mediated or -related disorders. The invention further relates to drug-screening methods using the PGP synthase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the PGP synthase polypeptides and polynucleotides. The invention further relates to procedures for producing the PGP synthase polypeptides and polynucleotides.

1 - 18 . (canceled)  
     
     
         19 . An isolated polypeptide selected from the group consisting of: 
 a) a polypeptide encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to SEQ ID NO:1, SEQ ID NO:3, or the nucleotide sequence of the cDNA insert in the plasmid deposited with ATCC as Patent Deposit Number PTA-2011, wherein said polypeptide has phosphatidyl-glycerolphosphate synthase activity; and    b) a polypeptide which is at least 95% identical to the amino acid sequence SEQ ID NO:2, wherein the polypeptide has phosphatidyl-glycerolphosphate synthase activity.    
     
     
         20 . An isolated polypeptide selected from the group consisting of: 
 a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2;    b) a polypeptide consisting of the amino acid sequence of SEQ ID NO:2;    c) a polypeptide which is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3; and    d) a polypeptide which is encoded by the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number PTA-2011.    
     
     
         21 . The polypeptide of  claim 19 , further comprising heterologous amino acid sequences.  
     
     
         22 . The polypeptide of claims  20 , further comprising heterologous amino acid sequences.