Method and apparatus for acne treatment

Abstract

Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 mW. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.

1 . A method, comprising: 
 exposing tissue containing acne bacteria to at least one source of light having emissions at a wavelength from about 300 nm and about 1400 nm;    operating the at least one source of light at a power output of about 20 mW or lower; and    observing a reduction in acne bacteria present on or in the tissue.    
   
   
       2 . The method of  claim 1  wherein the acne bacteria is present in or on the tissue selected from the group consisting of sebaceous oil glands, sebaceous ducts, sebocytes, supporting tissue thereof, and combinations thereof.  
   
   
       3 . The method of  claim 1  wherein the source of light is a narrowband, multichromatic electromagnetic radiation.  
   
   
       4 . The method of  claim 3  wherein the narrowband, multichromatic electromagnetic radiation has a dominant emissive wavelength of from about 390 nm to about 1400 nm.  
   
   
       5 . The method of  claim 4  wherein the dominant emissive wavelength is selected from the group consisting of 400 nm, 420 nm, 430 nm, 445 nm, 475 nm, 590 nm, 635 nm, 655 nm, 660 nm, 670 nm, 780 nm, 785 nm, 810 nm, 830 nm, 840 nm, 860 nm, 904 nm, 915 nm, 980 nm, 1015 nm, 1060 nm, 1260 nm, and 1400 nm.  
   
   
       6 . The method of  claim 1  comprising applying a photomodulation enhancing agent to the tissue containing or surrounding the acne bacteria.  
   
   
       7 . The method of  claim 6  wherein said photomodulation enhancing agent comprises a composition have an active agent selected from the group consisting of at least one of Vitamin C, Vitamin E, Vitamin A, Vitamin K, Vitamin F, Retin A (Tretinoin), Adapalene, Retinol, Hydroquinone, Kojic acid, a growth factor, echinacea, an antibiotic, an antifungal, an antiviral, a bleaching agent, an alpha hydroxy acid, a beta hydroxy acid, salicylic acid, antioxidant triad compound, a seaweed derivative, a salt water derivative, an antioxidant, a phytoanthocyanin, epigallocatechin-3-ganate, a phytonutrient, a botanical product, a herbaceous product, a hormone, an enzyme, a mineral, a genetically engineered substance, a cofactor, a catalyst, an antiaging substance, insulin, trace elements (including ionic calcium, magnesium, etc), minerals, Rogaine, a hair growth stimulating substance, a hair growth inhibiting substance, a dye, a natural or synthetic melanin, a metalloproteinase inhibitor, proline, hydroxyproline, an anesthetic substance, chlorophyll, copper chlorophyllin, chloroplasts, carotenoids, bacteriochlorophyll, phycobilins, carotene, xanthophyll, anthocyanin, and derivatives, subcomponents, and analogs of the above, both natural and synthetic, and mixtures thereof.  
   
   
       8 . The method of  claim 7  wherein the photomodulation enhancing agent is selected from the group consisting of chlorophyll, carotenoids, bacteriochlorophyll, phycobilins, porphyrins, derivatives thereof, and mixtures thereof.  
   
   
       9 . The method of  claim 1  further comprising subjecting the photomodulation enhancing agent to a penetration enhancing procedure prior to exposing said photomodulation enhancing agent to said source of electromagnetic radiation.  
   
   
       10 . The method of  claim 9  wherein the penetration enhancing procedure comprises a procedure selected from the group consisting of enzyme peel, microderm abrasion, solvent stripping, tape stripping, scrubbing, laser ablation, laser vaporization, chemical peeling, electrical stimulation, laser treatments using high peak power and short pulse durations, ultrasound, or combinations thereof.  
   
   
       11 . The method of  claim 9  wherein the penetration enhancing procedure comprises microdermabrasion.  
   
   
       12 . The method of  claim 9  wherein the penetration enhancing procedure comprises exposing said photomodulation enhancing agent to ultrasound.  
   
   
       13 . The method of  claim 4  wherein the source of narrowband, multichromatic electromagnetic radiation is a light emitting diode.  
   
   
       14 . The method of  claim 13  wherein the energy output of the light emitting diode is from about 0.5 mW to about 20 mW.  
   
   
       15 . The method of  claim 14  wherein the energy output of the light emitting diode is about 4 mW.  
   
   
       16 . The method of  claim 15  wherein the light emitting diode has a dominant wavelength selected from 400 nm, 420 nm, 430 nm, 445 nm, 475 nm, 590 nm, 635 nm, 655 nm, 660 nm, 670 nm, 780 nm, 785 nm, 810 nm, 830 nm, 840 nm, 860 nm, 904 nm, 915 nm, 980 nm, 1015 nm, 1060 nm, 1260 nm, and 1400 nm.  
   
   
       17 . A method, comprising: 
 exposing acne bacteria to at least one source of narrowband, multichromatic electromagnetic radiation having at least one dominant emissive wavelength between about 300 nm and about 1400 nm and a power output of from about 0.5 mW to about 20 mW continuously for a time of from about 0.5 minutes to about 60 minutes.    
   
   
       18 . The method of  claim 17  wherein the tissue is continuously exposed to the source of narrowband, multichromatic electromagnetic radiation for a time of about 15 minutes.  
   
   
       19 . The method of  claim 17  wherein the the energy output of the source of narrowband, multichromatic electromagnetic radiation is about 4 mW.  
   
   
       20 . The method of  claim 17  comprising applying a photomodulation enhancing agent to the tissue containing or surrounding the acne bacteria.  
   
   
       21 . The method of  claim 20  wherein said photomodulation enhancing agent comprises a composition have an active agent selected from the group consisting of at least one of Vitamin C, Vitamin E, Vitamin A, Vitamin K, Vitamin F, Retin A (Tretinoin), Adapalene, Retinol, Hydroquinone, Kojic acid, a growth factor, echinacea, an antibiotic, an antifungal, an antiviral, a bleaching agent, an alpha hydroxy acid, a beta hydroxy acid, salicylic acid, antioxidant triad compound, a seaweed derivative, a salt water derivative, an antioxidant, a phytoanthocyanin, epigallocatechin-3-ganate, a phytonutrient, a botanical product, a herbaceous product, a hormone, an enzyme, a mineral, a genetically engineered substance, a cofactor, a catalyst, an antiaging substance, insulin, trace elements (including ionic calcium, magnesium, etc), minerals, Rogaine, a hair growth stimulating substance, a hair growth inhibiting substance, a dye, a natural or synthetic melanin, a metalloproteinase inhibitor, proline, hydroxyproline, an anesthetic substance, chlorophyll, copper chlorophyllin, chloroplasts, carotenoids, bacteriochlorophyll, phycobilins, carotene, xanthophyll, anthocyanin, and derivatives, subcomponents, and analogs of the above, both natural and synthetic, and mixtures thereof.  
   
   
       22 . The method of  claim 20  wherein the photomodulation enhancing agent is selected from the group consisting of chlorophyll, carotenoids, bacteriochlorophyll, phylocibins, porphyrins, derivatives thereof, and mixtures thereof.  
   
   
       23 . The method of  claim 20  further comprising subjecting the photomodulation enhancing agent to a penetration enhancing procedure prior to exposing said photomodulation enhancing agent to said source of electromagnetic radiation.  
   
   
       24 . The method of  claim 23  wherein the penetration enhancing procedure comprises a procedure selected from the group consisting of enzyme peel, microderm abrasion, solvent stripping, tape stripping, scrubbing, laser ablation, laser vaporization, chemical peeling, electrical stimulation, laser treatments using high peak power and short pulse durations, ultrasound, or combinations thereof.  
   
   
       25 . The method of  claim 24  wherein the penetration enhancing procedure comprises microdermabrasion.  
   
   
       26 . The method of  claim 24  wherein the penetration enhancing procedure comprises exposing said photomodulation enhancing agent to ultrasound.  
   
   
       27 . A method, comprising: 
 exposing acne bacteria to at least one source of narrowband, multichromatic electromagnetic radiation having at least one dominant emissive wavelength between about 300 nm and about 1400 nm and a power output of from about 0.5 mW to about 20 mW, wherein the source of narrowband, multichromatic electromagnetic radiation is pulsed at least 2 times.    
   
   
       28 . The method of  claim 27  wherein the tissue is exposed to about 2 to about 2000 pulses from the source of narrowband, multichromatic electromagnetic radiation.  
   
   
       29 . The method of  claim 28  wherein each pulse is from about 1 millisecond to about 1000 milliseconds.  
   
   
       30 . The method of  claim 29  wherein each pulse is separated by from about 1 to about 1000 milliseconds.  
   
   
       31 . The method of  claim 27  wherein the source of narrowband, multichromatic electromagnetic radiation is pulsed about 100 times for about 250 milliseconds per pulse with a separation of about 100 milliseconds between each pulse.  
   
   
       32 . The method of  claim 31  wherein the the energy output of the source of narrowband, multichromatic electromagnetic radiation is about 4 mW.  
   
   
       33 . The method of  claim 27  comprising applying a photomodulation enhancing agent to the tissue containing or surrounding the acne bacteria.  
   
   
       34 . The method of  claim 33  wherein said photomodulation enhancing agent comprises a composition have an active agent selected from the group consisting of at least one of Vitamin C, Vitamin E, Vitamin A, Vitamin K, Vitamin F, Retin A (Tretinoin), Adapalene, Retinol, Hydroquinone, Kojic acid, a growth factor, echinacea, an antibiotic, an antifungal, an antiviral, a bleaching agent, an alpha hydroxy acid, a beta hydroxy acid, salicylic acid, antioxidant triad compound, a seaweed derivative, a salt water derivative, an antioxidant, a phytoanthocyanin, epigallocatechin-3-ganate, a phytonutrient, a botanical product, a herbaceous product, a hormone, an enzyme, a mineral, a genetically engineered substance, a cofactor, a catalyst, an antiaging substance, insulin, trace elements (including ionic calcium, magnesium, etc), minerals, Rogaine, a hair growth stimulating substance, a hair growth inhibiting substance, a dye, a natural or synthetic melanin, a metalloproteinase inhibitor, proline, hydroxyproline, an anesthetic substance, chlorophyll, copper chlorophyllin, chloroplasts, carotenoids, bacteriochlorophyll, phycobilins, carotene, xanthophyll, anthocyanin, and derivatives, subcomponents, and analogs of the above, both natural and synthetic, and mixtures thereof.  
   
   
       35 . The method of  claim 33  wherein the photomodulation enhancing agent is selected from the group consisting of chlorophyll, carotenoids, bacteriochlorophyll, phycobilins, porphyrins, derivatives thereof, and mixtures thereof.  
   
   
       36 . The method of  claim 33  further comprising subjecting the photomodulation enhancing agent to a penetration enhancing procedure prior to exposing said photomodulation enhancing agent to said source of electromagnetic radiation.  
   
   
       37 . The method of  claim 36  wherein the penetration enhancing procedure comprises a procedure selected from the group consisting of enzyme peel, microderm abrasion, solvent stripping, tape stripping, scrubbing, laser ablation, laser vaporization, chemical peeling, electrical stimulation, laser treatments using high peak power and short pulse durations, ultrasound, or combinations thereof.  
   
   
       38 . The method of  claim 37  wherein the penetration enhancing procedure comprises microdermabrasion.  
   
   
       39 . The method of  claim 37  wherein the penetration enhancing procedure comprises exposing said photomodulation enhancing agent to ultrasound.