Hydrophobic elastomeric polymer chemistry device for inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis

Abstract

A system and method for treating onychomycosis and skin conditions such as urushiol-induced allergic contact dermatitis comprises coating the affected nail or skin with a solution comprising an at least a primary diamine with modified diphenylmethane diisocyanates and a carrier solvent/reactant. A secondary diamine may be mixed with the primary diamine in an oligomeric, stoichiometrically balanced blend. Upon topical application, the carrier solvent/reactant evaporates, allowing polymerization of the remaining solution constituents to form a non-toxic, hydrophobic, elastomeric polyureathane linked copolymer coating that provides a barrier against moisture impregnation, inhibiting the growth of dermatophytes and urushiol-infected skin cells.

1 . A composition for the topical treatment of onychomycosis and urushiol-induced allergic contact dermatitis, the composition comprising a mixture of: 
 a primary diamine in a volume ratio ranging from about 3.6% to about 12.2% v/v of the total solution;    a chain extension reagent in a volume ratio ranging from about 2.0% to about 6.2% v/v of the composition; and    a stabilizing carrier in an amount sufficient to prevent formation of a gel or solid prior to removal of a portion of the stabilizing carrier.    
     
     
         2 . The composition of  claim 1  wherein the volume ratio of the primary diamine ranges from about 5.8% to about 9.6% v/v of the total solution.  
     
     
         3 . The composition of  claim 1  wherein the volume ratio of the primary diamine ranges from about 6.2% to about 7.8% v/v of the total solution.  
     
     
         4 . The composition of  claim 1  further comprising a secondary diamine in a volume ratio ranging from about 0.6% to about 6.8% v/v of the total solution.  
     
     
         5 . The composition of  claim 1  wherein the volume ratio of the secondary diamine ranges from about 2.4% to about 4.8% v/v of the total solution.  
     
     
         6 . The composition of  claim 1  wherein the volume ratio of the secondary diamine ranges from about 2.8% to about 3.8% v/v of the total solution.  
     
     
         7 . The composition of  claim 4  wherein the primary diamine and the secondary diamine are stoichiometrically balanced.  
     
     
         8 . The composition of  claim 1  wherein the primary diamine is a polyoxypropylene diamine.  
     
     
         9 . The composition of  claim 4  wherein the secondary diamine is a dialkylamino diphenylamines.  
     
     
         10 . The composition of  claim 4  wherein the ratio of the primary diamine and secondary diamine to the chain extension reagent is from about 2.8:1 to about 3.8:1 by volume.  
     
     
         11 . The composition of  claim 1  wherein the chain extension reagent is selected from the group consisting of methylene-4,4′-diphenyl diisocyanate [MDI], MDI-containing resins, modified MDI, MDI-containing resins, aliphatic diisocyanates, aromatic diisocyanates, alicyclic diisocyanates, ethylene diisocyanate, ethylidene diisocyanate, propylene diisocyanate, butylene diisocyanate, cyclopentylene-1,3-diisocyanate, cyclohexylene-l,4-diisocyanate, cyclohexylene-1,2.diisocyanate, 2,4-tolylene diisocyanate, 2,6-tolylene diisocyanate, 4,4′-diphenylmethane diisocyanate, 2,2-diphenylpropane-4,4′-diisocyanate, p-phenylene diisocyanate, m-phenylene 15 diisocyanate, xylylene diisocyanate, 1,4-napthylene diisocyanate, 1,5-naphthylene diisocyanate, diphenyl-4,4′ diisocyanate, azobenzene-4,4′-diisocyanate, diphenylsulfone-4,4′-diisocyanate, dichlorohexamethylene diisocyanate, tetramethylene diisocyanate, pentametylene diisocyanate, hexamethylene diisocyanate, 1-chlorobenzene-2,4-diisocyanate, furfurylidene diisocyanate and triphenyl methane triisocyanate  
     
     
         12 . The composition of  claim 1  wherein the chain stabilizing carrier is provided in an amount from about 60% to about 80% v/v of the composition.  
     
     
         13 . The composition of  claim 1  wherein the stabilizing carrier is selected from the group consisting of: acetone, methyl ethyl ketone, methylisobutylketone, N-methylcyclohexanone, acetaldehyde, propionaldehyde, butryaldehyde, isobutyraldehyde, methyl acetate, ethyl acetate, butyl acetate, methoxy propyl acetate, ethylene glycol, propylene glycol, butylene glycols, polyethylene glycol 200, polyethylene glycol 400 and polyethylene glycol 600.  
     
     
         14 . The composition of  claim 1  further comprising a secondary carrier for regulating viscosity.  
     
     
         15 . The composition of  claim 14  wherein the secondary carrier is provided in an amount from about 20% to about 38% v/v of the composition.  
     
     
         16 . The composition of  claim 14  wherein the secondary carrier is selected from the group consisting of: mineral spirits, N-methyl pyrrolidone and Solvesso solvent Lactone.  
     
     
         17 . The composition of  claim 1  further comprising a poly(oxyalkalene)polyol in an amount sufficient to support the function of the carrier solvent reactant.  
     
     
         18 . The composition of  claim 17  wherein the poly(oxyalkalene)polyol is provided in an amount from about 3.2% to about 4.6% v/v of the composition.  
     
     
         19 . The composition of  claim 18  wherein the poly(oxyalkalene)polyol is selected from the group consisting of: propylene oxide adducts of trimethylol propane, (C 3 HO) 12 C 6 H 14 O 3  and CAS #25723-16-4.  
     
     
         20 . The composition of  claim 1  further comprising a colorant or pigment.  
     
     
         21 . A method of treating onychomycosis or urushiol-induced allergic contact dermatitis by topical application of a polyureathane linked copolymer, comprising: 
 combining a primary diamine with modified diphenylmethane diisocyanates and a first carrier solvent/reactant to form a solution;    coating an affected nail or skin with the solution; and    drying the solution to form a polyureathane linked copolymer coating over the affected area.    
     
     
         22 . The method of  claim 21  further comprising combing the primary diamine with a secondary diamine in an oligomeric, stoichiometrically balanced blend.  
     
     
         23 . The method of  claim 21  wherein the first carrier solvent/reactant comprises acetone.  
     
     
         24 . The method of  claim 21  wherein the solution additionally includes a second carrier solvent/reactant.  
     
     
         25 . The method of  claim 24  wherein the second carrier solvent/reactant comprises mineral spirits.  
     
     
         26 . The method of  claim 21  wherein the solution additionally includes a polyether oxyalkylene polyol.  
     
     
         27 . The method of  claim 21  wherein polymerization of the polyureathane linked copolymer is initiated immediately upon application of the polyureathane linked copolymer to the skin or nail, without a modification of external ambient conditions.  
     
     
         28 . The method of  claim 21  wherein the polyureathane linked copolymer has a % distention-to-yield value of about 450% to about 680%.  
     
     
         29 . The method of  claim 21  wherein the solution further includes a colorant or stain.