Composite of support matrix and collagen, and process for producing support substrate and composite

Abstract

A cylindrical body is produced which is composed of a fiber structure with a basis weight of 1-50 g/m 2 and having a diameter of 0.5-50 mm and a bellows-shaped section, wherein the crest-to-crest spacing of the bellows-shaped section is no greater than 2 mm and the crest-to-valley depth of the bellows-shaped section is 0.01-1 mm; collagen is added to the cylindrical body to produce a composite comprising the cylindrical body and collagen.

1 . A composite comprising collagen and a support matrix made of a fiber structure composed of aliphatic polyester fibers with a mean fiber size of 0.05-50 μm.  
   
   
       2 . A composite according to  claim 1 , wherein said fiber structure is a biodegradable polymer.  
   
   
       3 . A composite according to  claim 2 , wherein said fiber structure is an aliphatic polyester.  
   
   
       4 . A composite according to  claim 3 , wherein said aliphatic polyester is polylactic acid, polyglycolic acid, polycaprolactone or a copolymer thereof.  
   
   
       5 . A composite according to  claim 1 , wherein said support matrix is a cylindrical body with a bellows-shaped section.  
   
   
       6 . A composite according to  claim 5 , wherein said cylindrical body is a cylindrical body which is composed of a fiber structure with a basis weight of 1-50 g/m 2  and has a membrane thickness of 0.05-0.2 mm and a diameter of 0.5-50 mm, wherein the spacing of the bellows-shaped section is no greater than 2 mm and the depth of the bellows-shaped section is 0.1-10 mm.  
   
   
       7 . A cylindrical body characterized by being composed of a fiber structure with a basis weight of 1-50 g/m 2  and having a membrane thickness of 0.05-0.2 mm and a diameter of 0.5-50 mm, wherein the spacing of the bellows-shaped section is no greater than 2 mm and the depth of the bellows-shaped section is 0.1-10 mm.  
   
   
       8 . A cylindrical body according to  claim 7 , wherein said cylindrical body is a biodegradable polymer.  
   
   
       9 . A composite according to  claim 8 , wherein said fiber structure is an aliphatic polyester.  
   
   
       10 . A cylindrical body according to  claim 9 , wherein said aliphatic polyester is polylactic acid, polyglycolic acid, polycaprolactone or a copolymer thereof.  
   
   
       11 . A cylindrical body according to  claim 7 , wherein the mean fiber size of said cylindrical body is 0.05-50 μm.  
   
   
       12 . A method for production of a cylindrical body composed of a fiber structure with a basis weight of 1-50 g/m 2 , wherein the spacing of the bellows-shaped section is no greater than 2 mm and the depth of the bellows-shaped section is 0.01-0.1 mm, which method comprises a stage of producing a solution of an aliphatic polyester in a volatile solvent, a stage of spinning said solution by an electrostatic spinning method, a stage of obtaining a fiber structure accumulated on a collector, and a stage of molding said fiber structure into a cylindrical body having a bellows-shaped section with a spacing of no greater than 2 mm.  
   
   
       13 . A method for production of a composite composed of a cylindrical body and collagen, wherein a composite is formed of a cylindrical body produced by a method according to  claim 12 , and collagen.  
   
   
       14 . A method for production of a composite composed of a cylindrical body and collagen, wherein a cylindrical body produced by a method according to  claim 12  is impregnated with a solution comprising collagen dissolved and/or dispersed in a solvent, and then at least one method is employed to fix the collagen by gelling, crosslinking or drying.