Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same

Abstract

Compounds of the formula (I) a process for their preparation and their use as medicaments are described.

1 . (canceled)  
     
     
         2 . (canceled)  
     
     
         3 . (canceled)  
     
     
         4 . (canceled)  
     
     
         5 . (canceled)  
     
     
         6 . (canceled)  
     
     
         7 . (canceled)  
     
     
         8 . (canceled)  
     
     
         9 . (canceled)  
     
     
         10 . A method for the treatment of disorders of the urogenital region and cancer comprising administering to a patient in need thereof an effective amount of a compound of formula (I)  
       
         
           
           
               
               
           
         
       
       in which 
 n represents a number 2, 3 or 4,  
 R 1  represents hydrogen or (C 1 -C 4 )-alkyl  
 and  
 R 2  represents pyridyl or thiazolyl which for its part may be substituted by (C 1 -C 4 )-alkyl, halogen, amino, dimethylamino, acetylamino, guanidino, pyridylamino, thienyl, furyl, imidazolyl, pyridyl, morpholinyl, thiomorpholinyl, piperdinyl, piperazinyl, N—(C 1 -C 4 )-alkylpiperazinyl, pyrrolidinyl, oxazolyl, isoxazolyl, pyrimidinyl, pyrazinyl, optionally (C 1 -C 4 )-alkyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by halogen, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy,  
 or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.  
 
     
     
         11 . A method for the treatment of inflammatory and neuroinflammatory disorders, neurodegenerative disorders and pain comprising administering to a patient in need thereof an effective amount of a compound of formula (I)  
       
         
           
           
               
               
           
         
       
       in which 
 n represents a number 2, 3 or 4,  
 R 1  represents hydrogen or (C 1 -C 4 )-alkyl  
 and  
 R 2  represents pyridyl or thiazolyl which for its part may be substituted by (C 1 -C 4 )-alkyl, halogen, amino, dimethylamino, acetylamino, guanidino, pyridylamino, thienyl, furyl, imidazolyl, pyridyl, morpholinyl, thiomorpholinyl, piperidinyl, piperazinyl, N—(C 1 -C 4 )-alkylpiperazinyl, pyrrolidinyl, oxazolyl, isoxazolyl, pyrimidinyl, pyrazinyl, optionally (C 1 -C 4 )-alkyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by halogen, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy,  
 or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.  
 
     
     
         12 . The method of  claim 10 , wherein the compound of formula (I) is characterized 
 n represents the number 2,    R 1  represents hydrogen, methyl or ethyl,    and    R 2  represents pyridyl or thiazolyl which for its part may be substituted by methyl, ethyl, fluorine, chlorine, amino, dimethylamino, acetylamino, guanidino, 2-pyridylamino, 4-pyridylamino, thienyl, pyridyl, morpholinyl, piperidinyl, optionally methyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by chlorine or methoxy,    or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.    
     
     
         13 . The method of  claim 10 , wherein the compound of formula (I) is characterized 
 n represents the number 2,    R 1  represents hydrogen or methyl    and    R 2  represents pyridyl or thiazolyl which for its part may be substituted by methyl, chlorine, amino, dimethylamino, acetylamino, guanidino, 2-pyridylamino, 4-pyridylamino, thienyl, pyridyl, morpholinyl, 2-methylthiazol-5-yl, phenyl, 4-chlorophenyl or 3,4,5-trimethoxyphenyl,    or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.    
     
     
         14 . The method of  claim 10 , wherein the compound of formula (I) has the following structure  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.  
     
     
         15 . The method of  claim 11 , wherein the compound of formula (I) is characterized 
 n represents the number 2,    R 1  represents hydrogen, methyl or ethyl,    and    R 2  represents pyridyl or thiazolyl which for its part may be substituted by methyl, ethyl, fluorine, chlorine, amino, dimethylamino, acetylamino, guanidino, 2-pyridylamino, 4-pyridylamino, thienyl, pyridyl, morpholinyl, piperidinyl, optionally methyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by chlorine or methoxy,    or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.    
     
     
         16 . The method of  claim 11 , wherein the compound of formula (I) is characterized 
 n represents the number 2,    R 1  represents hydrogen or methyl    and    R 2  represents pyridyl or thiazolyl which for its part may be substituted by methyl, chlorine, amino, dimethylamino, acetylamino, guanidino, 2-pyridylamino, 4-pyridylamino, thienyl, pyridyl, morpholinyl, 2-methylthiazol-5-yl, phenyl, 4-chlorophenyl or 3,4,5-trimethoxyphenyl,    or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.    
     
     
         17 . The method of  claim 11 , wherein the compound of formula (I) has the following structure  
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.