Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same

Abstract

The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.

1 . A compound of formula (I),  
       
         
           
           
               
               
           
         
         enantiomers, diastereomers, salts, and solvates thereof wherein  
         X is selected from O or S;  
         R 1  is selected from hydrogen, C 1 -3 alkyl, C 2 -3 alkenyl, and C 2 -3 alkynyl;  
         R 2  is hydrogen, halo, cyano, 
 (b) alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, cycloalkoxy, heterocyclooxy, aryloxy, heteroaryloxy, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1a , Z 2a  and Z 3a ; or  
 (c) —OR 10a , —SR 10a , or —SO 2 R 10a ;  
 
         R 3  and R 4  are independently selected from 
 (a) hydrogen,  
 (b) alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b ;  
 (c) —OR 11 , —NR 12 R 13 , —N(R 12 )C(O)R 14 , —N(R 12 )C(O)OR 14 , —N(R 12 )SO 2 R 14 , —N(R 12 )C(O)NR 12a R 13 , or —N(R 12 )SO 2 NR 12a R 13  or —C(O)OR 14 , —C(O)R 11 , —C(O)NR 12 R 13 , —SO 2 R 14 , —SO 2 NR 12 R 13 ;  
 (d) R 3  and R 4  together with the nitrogen atom to which they are attached combine to form a 3 to 8 membered heterocyclic ring optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b ;  
 
         R 6  is 
 (a) hydrogen, hydroxy, halo, or cyano,  
 (b) alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclo, aryl, heteroaryl, (cycloalkyl)alkyl, (heterocyclo)alkyl, (aryl)alkyl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1d  Z 2d  and Z 3d ; or  
 (c) —OR 7a , —SR 7a , —NR 8a R 9a , —N(R 8a )SO 2 R 10 , —N(R 8a )SO 2 NR 8b R 9b , —N(R 8a )SO 2 R 10 , —N(R 8a )C(O)R 7a , —N(R 8a )N(R 8a )C(O)R 7a , —N(R 8a )C(O)NR 8b R 9b , —N(R 8a )C(O)OR 7a , —SO 2 R 10 , —SO 2 NR 8b R 9b , —C(O)R 7a , —C(O)OR 7a , —OC(O)R 7a , —C(O)NR 8a R 9a , or —OC(O)NR 8a R 9a ;  
 
         R 7a  and R 7b  are independently 
 (a) hydrogen, or  
 (b) alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1c , Z 2c  and Z 3c ;  
 
         R 8a , R 8b , R 9a  and R 9b  are independently 
 (a) hydrogen,  
 (b) alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1d , Z 2d  and Z 3d ; or  
 
         R 10 , R 10a , at each occurance, are independently alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1d , Z 2d  and Z 3d ;  
         R 11 , R 12 , R 12a  and R 13  are independently 
 (a) hydrogen, or  
 (b) alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1e , Z 2e  and Z 3e ;  
 
         R 14  is alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1e , Z 2e  and Z 3e ;  
         Z 1a-1e , Z 2a-2e , and Z 3a-3e  are optional substituents at each occurrence independently selected from —W 1 —V 1 ; —W 2 —V 2 ; —W 3 —V 3 ; —W 4 —V 4 ; —W 5 —V 5 ;  
         where W 1-5  are independently 
 (1) a bond  
 (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl; or  
 
         where V 1-5  are independently 
 (1) H  
 (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl;  
 (3) —U 1 —O—Y 5 ,  
 (4) —U 1 —S—Y 5 ,  
 (5) —U 1 —C(O) t —H, —U 1 —(O) t —Y 5  where t is 1 or 2,  
 (6) —U 1 —SO 3 —H, or —U 1 —S(O) t Y 5 ,  
 (7) —U 1 -halo,  
 (8) —U 1 -cyano,  
 (9) —U 1 -nitro,  
 (10) —U 1 —NY 2 Y 3 ,  
 (11) —U 1 —N(Y 4 )—C(O)—Y 1 ,  
 (12) —U 1 —N(Y 4 )—C(S)—Y 1 ,  
 (13) —U 1 —N(Y 4 )—C(O)—NY 2 Y 3 ,  
 (14) —U 1 —N(Y 4 )—C(S)—NY 2 Y 3 ,  
 (15) —U 1 —N(Y 4 )—C(O)O—Y 5 ,  
 (16) —U 1 —N(Y 4 )—S(O) 2 —Y 1 ,  
 (17) —U 1 —N(Y 4 )—S(O) 2 —NY 2 Y 3 ,  
 (18) —U 1 —C(O)—NY 2 Y 3 ,  
 (19) —U 1 —OC(O)—NY 2 Y 3    
 (20) —U 1 —S(O) 2 —N(Y 4 )—Y 1 ,  
 (21) —U 1 —N(Y 4 )—C(═NV 1a )—NY 2 Y 3 ,  
 (22) —U 1 —N(Y 4 )—C(═NV 1a )—Y 1 ,  
 (23) —U 1 —C(═NV 1a )—NY 2 Y 3 ,  
 (24) oxo;  
 (25) —U 1 —Y 5 ;  
 
         V 1a  is independently hydrogen, alkyl, —CN, —C(O)Y 1 , —S(O) 2 Y 5 , S(O) 2 NY 2 Y 3 ;  
         Y 1 , Y 2 , Y 3 , Y 4  and Y 5  
 (1) are each independently hydrogen, alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocylco)alkyl, heteroaryl, or (heteroaryl)alkyl, any of which may be optionally independently substituted as valence allows with one or more Z 4 , Z 5  and Z 6 ; or  
 (2) Y 2  and Y 3  may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, or  
 (4) Y 2  and Y 3  together with the nitrogen atom to which they are attached may combine to form a group —N═CY 6 Y 7  where Y 6  and Y 7  are each independently H or alkyl; and  
 
         Z 4 , Z 5 , and Z 6  are optional substituents at each occurrence independently selected from 
 (1) H  
 (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl;  
 (3) —U 1 —O—Y 5a ,  
 (4) —U 1 —S—Y 5a ,  
 (5) —U 1 —C(O) t —H, —U 1 —C(O) t —Y 5a  where t is 1 or 2,  
 (6) —U 1 —SO 3 —H, or —U 1 —S(O) t Y 5a ,  
 (7) —U 1 -halo,  
 (8) —U 1 -cyano,  
 (9) —U 1 -nitro,  
 (10) —U 1 —NY 2a Y 3a ,  
 (11) —U 1 —N(Y 4a )—C(O)—Y 1a ,  
 (12) —U 1 —N(Y 4a )—C(S)—Y 1a ,  
 (13) —U 1 —N(Y 4a )—C(O)—NY 2a Y 3a ,  
 (14) —U 1 —N(Y 4a )—C(S)—NY 2a Y 3a ,  
 (15) —U 1 —N(Y 4a )—C(O)O—Y 5a ,  
 (16) —U 1 —N(Y 4a )—S(O) 2 —Y 1a ,  
 (17) —U 1 —N(Y 4a )—S(O) 2 —NY 2a Y 3a ,  
 (18) —U 1 —C(O)—NY 2a Y 3a ,  
 (19) —U 1 —C(O)—NY 2a Y 3a    
 (20) —U 1 —S(O) 2 —N(Y 4a )—Y 1a ,  
 (21) —U 1 —N(Y 4a )—C(═NV 1a )—NY 2a Y 3a ,  
 (22) —U 1 —N(Y 4a )—C(═NV 1a )—Y 1a ,  
 (23) —U 1 —C(═NV 1a )—NY 2a Y 3a ,  
 (24) oxo;  
 (25) —U 1 —Y 5a ;  
 
         Y 1a , Y 2a , Y 3a , Y 4a  and Y 5a  
 (1) are each independently hydrogen, alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocylco)alkyl, heteroaryl, or (heteroaryl)alkyl;  
 
         U 1  is independently 
 (1) a single bond,  
 (2) alkylene,  
 (3) alkenylene, or  
 (4) alkynylene.  
 
       
     
     
         2 . A compound of  claim 1  wherein 
 R 3  and R 4  are independently 
 (a) hydrogen,  
 (b) alkyl, haloalkyl, (hydroxy)alkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclo, (heterocyclo)alkyl, aryl, (aryl)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b ;  
 (c) —NR 12 R 13 ; or  
 (d) R 3  and R 4  together with the nitrogen atom to which they are attached combine to form a 3 to 8 membered heterocyclic ring optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b .  
   
     
     
         3 . A compound of  claim 2  wherein 
 R 6  is 
 (a) hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, (cycloalkyl)alkyl, heterocyclo, (heterocyclo)alkyl, aryl, (aryl)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1d , Z 2d  and Z 3d ; or  
 (b) —OR 7a , —SR 7a , —NR 8a R 9a , —N(R 8a )SO 2 R 10 , —N(R 8a )SO 2 NR 8b R 9b , —N(R 8a )SO 2 R 10 , —N(R 8a )C(O)R 7a , —N(R 8a )N(R 8a )C(O)R 7a , —N(R 8a )C(O)NR 8b R 9b , —N(R 8a )C(O)OR 7a , —SO 2 R 10 , —SO 2 NR 8b R 9b , —C(O)R 7a , —C(O)OR 7a , —OC(O)R 7a , —C(O)NR 8a R 9a , or —OC(O)NR 8a R 9a .  
   
     
     
         4 . A compound of  claim 3  wherein 
 R 7a  is independently selected from 
 (a) hydrogen, or  
 (b) alkyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1c , Z 2c  and Z 3c .  
   
     
     
         5 . A compound of  claim 4  wherein 
 R 3  and    R 4  are independently hydrogen, alkyl, haloalkyl, (hydroxy)alkyl, cycloalkyl, (cycloalkyl)alkyl, (heterocyclo)alkyl, (aryl)alkyl or (heteroaryl)alkyl and of which may be optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b ; —NR 12 R 13 ; or    alternatively, R 3  and R 4  together with the nitrogen atom to which they are attached combine to form a 3 to 6 membered heterocyclic ring selected from piperidinyl, morpholinyl, pyrrolidinyl, piperazinyl, and azetidinyl; optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b ;    R 6  is 
 (a) hydrogen, alkyl, aryl, heteroaryl, cycloalkyl, (cycloalkyl)alkyl, heterocyclo, (heterocyclo)alkyl, aryl, (aryl)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1d , Z 2d  and Z 3d ; or  
 (b) —OR 7a , —SR 7a , —NR 8a R 9a , —N(R 8a )SO 2 R 10 , —N(R 8a )SO 2 R 10 , —N(R 8a )C(O)R 7a , —N(R 8a )N(R 8a )C(O)R 7a , —N(R 8a )C(O)NR 8b R 9b , —SO 2 R 10 , —C(O)R 7a , or —C(O)NR 8a R 9a .  
   
     
     
         6 . A compound of  claim 5  wherein 
 R 1  is hydrogen, methyl, ethyl, propyl, i-propyl, prop-2-enyl, prop-1-enyl; and    R 2  is hydrogen, methyl, trifluoromethyl, and phenyl.    
     
     
         7 . A compound of  claim 1  wherein 
 R 1  is selected from hydrogen and C 1 -3 alkyl;    R 6  is 
 (a) hydrogen, hydroxy, halo, or cyano,  
 (b) alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclo, aryl, heteroaryl, (cycloalkyl)alkyl, (heterocyclo)alkyl, (aryl)alkyl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1d , Z 2d  and Z 3d ; or  
 (c) —OR 7a , —SR 7a , —NR 8a R 9a , —N(R 8a )SO 2 R 10 , —N(R 8a )SO 2 NR 8b R 9b , —N(R 8a )SO 2 R 10 , —N(R 8a )C(O)R 7a , —N(R 8a )C(O)NR 8b R 9b , —N(R 8a )C(O)OR 7a , —SO 2 R 10 , —SO 2 NR 8b R 9b , —C(O)R 7a , —C(O)OR 7a , —OC(O)R 7a , —C(O)NR 8a R 9a , or —OC(O)NR 8a R 9a ;  
   Z 1a-1e , Z 2a-2e , and Z 3a-3e  are optional substituents at each occurrence independently selected from —W 1 —V 1 ; —W 2 —V 2 ; —W 3 —V 3 ; —W 4 —V 4 ; —W 5 —V 5 ;    where W 1-5  are independently 
 (1) a bond  
 (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl; or  
   where V 1-5  are independently 
 (1) H  
 (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl;  
 (3) —U 1 —O—Y 5 ,  
 (4) —U 1 —S—Y 5 ,  
 (5) —U 1 —C(O) t —H, —U 1 —C(O) t —Y 5  where t is 1 or 2,  
 (6) —U 1 —SO 3 —H, or —U 1 —S(O) t Y 5 ,  
 (7) —U 1 -halo,  
 (8) —U 1 -cyano,  
 (9) —U 1 -nitro,  
 (10) —U 1 —NY 2 Y 3 ,  
 (11) —U 1 —N(Y 4 )—C(O)—Y 1 ,  
 (12) —U 1 —N(Y 4 )—C(S)—Y 1 ,  
 (13) —U 1 —N(Y 4 )—C(O)—NY 2 Y 3 ,  
 (14) —U 1 —N(Y 4 )—C(S)—NY 2 Y 3 ,  
 (15) —U 1 —N(Y 4 )—C(O)O—Y 5 ,  
 (16) —U 1 —N(Y 4 )—S(O) 2 —Y 1 ,  
 (17) —U 1 —N(Y 4 )—S(O) 2 —NY 2 Y 3 ,  
 (18) —U 1 —C(O)—NY 2 Y 3 ,  
 (19) —U 1 —OC(O)—NY 2 Y 3    
 (20) —U 1 —S(O) 2 —N(Y 4 )—Y 1 ,  
 (21) —U 1 —N(Y 4 )—C(═NV 1a )—NY 2 Y 3 ,  
 (22) —U 1 —N(Y 4 )—C(═NV 1a )—Y 1 ,  
 (23) —U 1 —C(═NV 1a )—NY 2 Y 3 ,  
 (24) oxo;  
 (25) —U 1 —Y 5 ;  
   V 1a  is independently hydrogen, alkyl, —CN, —C(O)Y 1 , —S(O) 2 Y 5 , S(O) 2 NY 2 Y 3 ;    Y 1 , Y 2 , Y 3 , Y 4  and Y 5  
 (1) are each independently hydrogen, alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocylco)alkyl, heteroaryl, or (heteroaryl)alkyl; or  
 (2) Y 2  and Y 3  may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, or  
 (4) Y 2  and Y 3  together with the nitrogen atom to which they are attached may combine to form a group —N═CY 6 Y 7  where Y 6  and Y 7  are each independently H or alkyl.  
   
     
     
         8 . A compound of  claim 7  wherein 
 R 3  and R 4  are independently 
 (a) hydrogen,  
 (b) alkyl, haloalkyl, (hydroxy)alkyl, cycloalkyl, (cycloalkyl)alkyl, (heterocyclo)alkyl, (aryl)alkyl or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b ;  
 (c) NR 12 R 13 ; or  
 (d) R 3  and R 4  together with the nitrogen atom to which they are attached combine to form a 3 to 8 membered heterocyclic ring optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b .  
   
     
     
         9 . A compound of  claim 8  wherein 
 R 6  is 
 (a) alkyl, alkenyl, alkynyl, aryl, heteroaryl, (cycloalkyl)alkyl, (heterocyclo)alkyl, (aryl)alkyl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1d , Z 2d  and Z 3d ; or  
 (b) —OR 7a , —SR 7a , —NR 8a R 9a , —N(R 8a )SO 2 R 10 , —N(R 8a )SO 2 NR 8b R 9b , —N(R 8a )SO 2 R 10 , —N(R 8a )C(O)R 7a , —N(R 8a )C(O)NR 8b R 9b , —N(R 8a )C(O)OR 7a , —SO 2 R 10 , —SO 2 NR 8b R 9b , —C(O)R 7a , —C(O)OR 7a , —C(O)R 7a , —C(O)NR 8a R 9a , or —OC(O)NR 8a R 9a .  
   
     
     
         10 . A compound of  claim 9  wherein 
 R 7a  is independently selected from 
 (a) hydrogen, or  
 (b) alkyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1c , Z 2c  and Z 3c .  
   
     
     
         11 . A compound of  claim 10  wherein 
 Z 1b , Z 2b  and Z 3b  are optional substituents independently selected from alkyl, heteroaryl, —OH, —O—Y 5 , —U 1 —NY 2 Y 3 , —C(O) t H, —C(O) t Y 5 ;    Z 1c  is 
 (a) —OH, —OY 5  or  
 (b) aryl optionally substituted with —OH or —OY 5 ;  
   Z 1d , Z 2d  and Z 3d  are optional substituents independently selected from 
 (a) cyano, halo, —OH, —OY 5 , —U 1 —NY 2 Y 3 , —C(O) t H, —C(O) t Y, —S(O) t Y 5 ;  
 (b) alkyl or alkoxy optionally substituted with one or more cyano, halo, —OH, —OY, —U 1 —NY 2 Y 3 , —C(O) t H, —C(O) t Y, —S(O) t Y, —U 1 -heteroaryl.  
   
     
     
         12 . A compound of  claim 11  wherein 
 R 3  is hydrogen;    R 4  is alkyl, haloalkyl, (hydroxy)alkyl, cycloalkyl, (cycloalkyl)alkyl, (heterocyclo)alkyl, (aryl)alkyl or (heteroaryl)alkyl and of which may be optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b ;    alternatively, R 3  and R 4  together with the nitrogen atom to which they are attached combine to form a 3 to 6 membered heterocyclic ring selected from piperidinyl, morpholinyl, pyrrolidinyl, and azetidinyl; optionally independently substituted as valence allows with one or more Z 1b , Z 2b  and Z 3b ;    R 6  is 
 (a) alkynyl optionally substituted with Z 1d  where Z 1d  is aryl which may be further optionally independently substituted with one or more cyano, halo, —OH, —OY, —U 1 —NY 2 Y 3 , —C(O) t H, —C(O) t Y, or, —S(O) t Y;  
 (b) aryl optionally independently substituted as valence allows with one or more Z 1d , Z 2d  and Z 3d ; or  
 (c) —OR 7a , —SR 7a , —SO 2 R 10 , —SO 2 NR 8b R 9b , —OC(O)R 7a , or —OC(O)NR 8a R 9a ; 
 Z 1b , Z 2b  and Z 3b  are optional substituents independently selected from —OH, —OY, —U 1 —NY 2 Y 3 , —C(O) t H, —C(O) t Y, —U 1 —N(Y 4 )—C(O)—Y 1 , or —U 1 —N(Y 4 )—C(O)O—Y 5 , where 
 U 1  is a bond or alkylene;  
 
 
   Z 1c  is 
 (a) —OY where Y is aryl, or  
 (b) aryl optionally substituted with —OH or —OY where Y is alkyl;  
   Z 1d , Z 2d  and Z 3d  are optional substituents independently selected from 
 (a) cyano, halo, —OH, —OY, —C(O) t H, —C(O) t Y, —S(O) t Y, or 
 (b) alkyl or alkoxy optionally substituted with one or more cyano, halo, —OH, —OY, —U 1 —NY 2 Y 3 , —C(O) t H, —C(O) t Y, —S(O) t Y, —U 1 —N(Y 4 )—C(O)—Y 1 , —U 1 —N(Y 4 )—C(O)—Y 1 , or —U 1 —N(Y 4 )—S(O) 2 —Y 1 ,  
 where 
 U 1  is a bond or alkylene.  
 
 
   
     
     
         13 . A compound of  claim 12  wherein 
 R 1  is alkyl; and    R 2  is hydrogen.    
     
     
         14 . A compound of  claim 1 , wherein the compound is selected from 
 8-Methyl-5-methylamino-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-fluorophenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-bromophenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-trifluoromethoxyphenyl]8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-chlorophenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-methylphenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-(dimethylamino)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-methoxyphenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[4-hydroxypiperidin-1-yl]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[morpholin-1-yl]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[(tetrazol-5-ylmethyl)methylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[2-hydroxyethylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[3-dimethylamino)propylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[N′N′-dimethylhydrazino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(tetrazol-5-yl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-cyanophenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-(methoxycarbonyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-(methylaminocarbonyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[4-(carboxy)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-[2-(tetrazol-5yl)(E)-ethenyl]phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-[2-(tetrazol-5-yl)ethyl]phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-methyl-5-dimethylamino-2-[3-[2-(tetrazol-5-yl)ethyl]phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-cyano-(E)-ethenyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-carboxyethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-ethoxycarbonyl-(E)-prop-2-enyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-carboxy-(E)-prop-2-enyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    4-Methyl-7-[3-aminopropylamino]-2-phenyl-4H-imidazo[4,5-d]oxazolo[4,5-b]pyridine;    4-Methyl-7-[3-methylaminopropylamino]-2-phenyl-4H-imidazo[4,5-d]oxazolo[4,5-b]pyridine;    8-Methyl-5-methylamino-2-(2-methylethyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-dimethylamino-2-(2-methylethyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(2,2-dimethylpropyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(cyclopentylmethyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(2-furyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(2,4-dimethylphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3,4-dimethylphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3-methylphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3-trifluoromethyl-4-methylphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3-trifluoromethylphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3-methoxyphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(2-methylbutyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3,5-dimethylphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3-phenyloxyphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3-methyl-4-fluorophenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-ethylamino-2-(3-methyl-4-fluorophenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(2-trifluoromethylpyridin-5-yl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3,5-dimethoxyphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(trans-2-phenyl cyclopropyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(2,3-dimethylphenyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(2,2-dimethylethyl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-ethyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-propyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-(Phenylmethylamino)-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(pyridine-2-yl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(pyridine-3-yl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(pyridine-4-yl)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-(2-methylethylamino)-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-methyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-(2-aminoethylamino)-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[3-dimethylaminopropylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[ethylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[(2-hydroxypropyl)amino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[cyclopentylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[2-dimethylaminoethylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[((tetrahydrofuran-2-yl)methyl)amino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[2-(acetylamino)ethylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[(5-hydroxy-3-oxypentyl)amino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[2-(1-pyrrolidinyl)ethylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[2-(pyridin-2-yl))ethylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[3-(imidazol-1-yl)propylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[2-(morpholin-4-yl)ethylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[3-(morphylin-4-yl)propylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-[3-(1-methyl-4-piperazinyl)propylamino]-2-phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-(3-aminomethyl)phenyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[(3-acetylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(phenylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(ethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(pyrazin-2-ylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(1-cyanocyclopropylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(1-phenylcyclopropylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((trans-2-phenylcyclopropyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(cyclobutylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(cyclopentylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(1-phenylcyclopentylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(cyclopentylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(cyclohexylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(cyclohexylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-fluorophenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    5-Methyl-8-methylamino-2-[3-((2,5-difluorophenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2,6-difluorophenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-chlorophenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-methoxyphenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-trifluoromethylphenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((3-fluorophenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((3-dimethylaminophenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((3-methoxyphenyl)aminophenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((3-methylphenyl)aminophenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(4-(dimethylamino)phenyl carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-methylethyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-methylpropyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2,2-dimethylpropyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-methylpropyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-phenyloxyethyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(phenylethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(propylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-furyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(cycloheptylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2,2-dimethylethyl)carbonylaminomethl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((difluoromethyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((difluoromethyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-(trifluoromethyl)phenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(3-(trans-phenylethenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(3-(3-phenylpropyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(butylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(pentylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(thiophen-2-ylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(thiophen-3-ylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(indol-3-ylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(furan-2-ylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(pyridin-2-ylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(pyridin-3-ylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(pyridin-4-ylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-piperidin-1-ylethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(4-nitrophenylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(acyloxyethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(imidazol-2-ylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(pyridin-3-ylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((1-methyl-1-phenylethyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(3-methylcarboxyphenylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(cyclopropylethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(methoxymethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(thiadiazol-4-ylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-(pyridine-3-yl)thiazol-4-yl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(4-dimethyaminophenylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2,2,2-trifluoroethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((1-ethyl-3-methylpyrazol-5-yl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((4-bromo-1-ethyl-3-methylpyrazol-5-yl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine    8-Methyl-5-methylamino-2-[3-(2-methylsulfonylphenylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(dihydrobenzoxazol-7-ylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((5-methylisoxazol-4-yl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(cycloheptylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(dimethylaminomethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((3-methylphenyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(aminomethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3(S-aminoethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((R-2-amino-3-methylpropyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((R-2-amino-4-methylbutyl)carbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(R-aminophenylmethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(R-amino-2-(phenyl)ethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(R-aminoethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(R-2-(aminocarbonyl)-1-amino ethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(S-1-amino-2-imidazol-4-yl-ethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(R-1-amino-R-2-methylbutylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(R-1-amino-4-aminobutylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(S-1-amino-4-guanidinylbutylylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(R-1-amino-S-2-hydroxypropylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(R-1-amino-2-carboxyethylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[benzothiazol-6-ylcarboxyphenylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[isoxazol-5-ylcarboxyphenylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[1-methylpyrrol-2-ylcarboxyphenylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[1-methylpyrrol-2-ylcarboxyphenylcarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(phenyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(ethyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-methoxyethyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-propynyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(4-fluorophenyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(4-methoxyphenyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-napthyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(isopropyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(3-butynyloxycarbonylaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-nitrophenylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(propylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-nitrophenylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-((2-acetamido-4-methylthiazol-5-yl)sulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(4-fluorophenylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2-trifluoromethoxyphenylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(3,5-dimethylisoxazol-4-ylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(2,5-difluorophenylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(4-acetylphenylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(5-methylisoxazol-4-ylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    8-Methyl-5-methylamino-2-[3-(thiophen-3-ylsulfonyloaminomethyl)phenyl]-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    2-[3-(1-amino-1-methylethyl)phenyl]-N,8-dimethyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    2-[3-(1-acetamido-1-methylethyl)phenyl]-N,8-dimethyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    2-[3-(1-amino-1-methylethyl)phenyl]-N,8-dimethyl-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridine;    N-[1-[5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]acetamide;    N-[1-[5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]oxazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]N-methylurea;    N,8-dimethyl-2-phenyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N,8-dimethyl-2-(methylthio)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine N-(3-methoxypropyl)-8-methyl-2-(methylthio)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N,8-dimethyl-2-[(1-methylethyl)thio]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N,8-dimethyl-2-(methylsulfonyl)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N,8-dimethyl-2-(1-piperidinyl)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    2-(hexahydro-1H-azepin-1-yl)-N,8-dimethyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    3-piperidinemethanol, 1-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 ,N 5 ,8-trimethyl-N 2 -(2-phenylethyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -(cyclopropylmethyl)-N 5 ,8-dimethyl-N 2 -propyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(4-morpholinyl)-;    piperazine, 1-acetyl-4-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(4-thiomorpholinyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -butyl-N 2 ,N 5 ,8-trimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -[2-(1H-indol-3-yl)ethyl]-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -cyclohexyl-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -(2,2-dimethylpropyl)-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -cyclopentyl-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 5 ,8-dimethyl-N 2 -(phenylmethyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 5 ,8-dimethyl-N 2 -pentyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -(3-methoxypropyl)-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 5 ,8-dimethyl-N 2 -(2-methylpropyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 — [(4-methoxyphenyl)methyl]-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -butyl-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 — [(2-methoxyphenyl)methyl]-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 — [(3-methoxyphenyl)methyl]-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -ethyl-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 — [(4-fluorophenyl)methyl]-N 5 ,8-dimethyl-;    N 2 -(2-ethoxyethyl)-N 5 ,8-dimethyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine;    3-piperidinecarboxamide, 1-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -(2-furanylmethyl)-N 5 ,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 5 ,8-dimethyl-N 2 -(3-pyridinylmethyl)-;    1-butanol, 4-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-;    1-pentanol, 2-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-;    1-propanol, 2-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-;    ethanol, 2-[2-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]ethoxy]-;    ethanol, 2-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(2,6-dimethyl-4-morpholinyl)-N,8-dimethyl-;    1H-1,4-diazepine, 1-acetylhexahydro-4-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    ethanol, 2-[ethyl[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(2,5-dihydro-1H-pyrrol-1-yl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3,6-dihydro-1 (2H)-pyridinyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 ,N 5 ,8-trimethyl-N 2 -2-propenyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 5 ,8-dimethyl-N 2 ,N 2 -di-2-propenyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -ethyl-N 5 ,8-dimethyl-N 2 -(2-methyl-2-propenyl)-;    ethanol, 2-[methyl[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 2 -butyl-N 2 -ethyl-N 5 ,8-dimethyl-;    ethanol, 2,2′-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]ino]bis-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2,5-diamine, N 5 ,8-dimethyl-N 2 ,N 2 -bis(1-methylethyl)-;    4-piperidinol, 1-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    2-fluoro-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-benzamide;    benzamide, 2-chloro-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 2-methoxy-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-(trifluoromethyl)-;    benzamide, 3-methyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 4-fluoro-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 4-methyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    propanamide, 2,2-dimethyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    propanamide, 2-methyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    acetamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl];    benzeneacetamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    butanamide, 3,3-dimethyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    butanamide, 3-methyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    propanamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzenepropanamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    butanamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    pentanamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    hexanamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    cyclopropanecarboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    cyclobutanecarboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    cyclopentanecarboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    cyclohexanecarboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 4-cyano-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    2-furancarboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    2-thiophenecarboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    2-thiopheneacetamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 3,5-dichloro-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    acetamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-(phenylmethoxy)-;    benzamide, 3-cyano-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    1,3-benzodioxole-5-carboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzo[b]thiophene-2-carboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-4-(trifluoromethoxy)-;    benzamide, 4-fluoro-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-(trifluoromethyl)-;    benzamide, 2,4,6-trifluoro-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    tricyclo[3.3.1.1 3,7 ]decane-1-carboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-benzamide,    N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2,5-bis(trifluoromethyl)-benzamide, 2,3,4-trifluoro-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]—;    3-furancarboxamide, 2,5-dimethyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    3-pyridinecarboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    4-pyridinecarboxamide, N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    3-pyridinecarboxamide, 2-(ethylthio)-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 4-(dimethylamino)-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    1H-pyrrole-2-carboxamide, 1-methyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    5-pyrimidinecarboxamide, 2-chloro-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-4-(trifluoromethyl)-;    propanamide, 2-(acetyloxy)-2-methyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzeneacetamide, alpha-(acetyloxy)-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    acetamide, 2-(acetyloxy)-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    propanamide, 2-(acetyloxy)-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-, (2S)-benzamide,    3-(acetyloxy)-2-methyl-N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    propanoic acid, 3-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-3-oxo-;    propanoic acid, 3-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-3-oxo-, ethyl ester;    butanoic acid, 4-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-4-oxo-;    butanoic acid, 4-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-4-oxo-, methyl ester;    pentanoic acid, 5-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-5-oxo-;    pentanoic acid, 5-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]-5-oxo-, methyl ester;    benzoic acid, 4-[[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]carbonyl]-;    benzoic acid, 4-[[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]amino]carbonyl]-, methyl ester;    1-[4-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]-ethanone;    N,8-dimethyl-2-[3-[1-[(2-phenylethyl)amino]ethyl]phenyl]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[(cyclohexylmethyl)amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[(tetrahydro-2-furanyl)methyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[1-(phenylmethyl)-4-piperidinyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[2-(1-piperidinyl)ethyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[(phenylmethyl)amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[[(2-fluorophenyl)methyl]amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[[(2-chlorophenyl)methyl]amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[[(2-methoxyphenyl)methyl]amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[(2-methylphenyl)methyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[[(3-fluorophenyl)methyl]amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[[(3-methoxyphenyl)methyl]amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[[3-(trifluoromethyl)phenyl]methyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[[(4-fluorophenyl)methyl]amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[(4-methylphenyl)methyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[(2,2-dimethylpropyl)amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[(3-methoxypropyl)amino]ethyl]phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-[1-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-N,8-dimethyl-;    1,3-propanediamine, N,N-dimethyl-N′-[1-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[(2-methylpropyl)amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[2-(4-morpholinyl)ethyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[3-(1-pyrrolidinyl)propyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-[1-[[2-(methylthio)ethyl]amino]ethyl]phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(3-pyridinyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(6-methoxy-3-pyridinyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[6-(methylamino)-3-pyridinyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[6-(4-morpholinyl)-3-pyridinyl]-;    benzenemethanol, 4-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzoic acid, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3-chloro-4-fluorophenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3,4-difluorophenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-fluoro-4-(methylamino)phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-isoquinolinyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[2-(methylamino)-3-pyridinyl]-;    2-furancarboxaldehyde, 5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[4-(aminomethyl)phenyl]-N,8-dimethyl-;    N,N-diethyl-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzamide;    3-piperidinemethanol, 1-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzoyl]-;    benzamide, N-methyl-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-(2-phenylethyl)-;    piperazine, 1-acetyl-4-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzoyl]-;    piperidine, 1-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzoyl]-;    thiomorpholine, 4-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzoyl]-;    piperazine, 1-methyl-4-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzoyl]-;    benzamide, N-[(3-chlorophenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-cyclohexyl-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-(1,1-dimethylethyl)-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-(3-pyridinylmethyl)-;    benzamide, N-[(2,5-dichlorophenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-(2-hydroxyethyl)-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-(2,2-dimethylpropyl)-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-(2-thienylmethyl)-;    benzamide, N-(2-ethoxyethyl)-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-(phenylmethyl)-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-pentyl-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-[(tetrahydro-2-furanyl)methyl]-;    benzamide, N-[(3,4-difluorophenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-[(2,4-dichlorophenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-[[3-(trifluoromethoxy)phenyl]methyl]-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-(2-methylpropyl)-;    benzamide, N-[(4-methoxyphenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-[(3,5-dimethoxyphenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-(4-hydroxybutyl)-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-[3-(dimethylamino)propyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-[(2-methoxyphenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-[(2-fluorophenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-(2-pyridinylmethyl)-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-(4-pyridinylmethyl)-;    benzamide, N-[(3-methoxyphenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-ethyl-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, N-[(4-fluorophenyl)methyl]-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzamide, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-N-(2-phenylethyl)-;    benzamide, N-(cyclopropylmethyl)-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxylic acid;    N,N-diethyl-8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(1H-benzimidazol-2-ylmethyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[(2-fluorophenyl)methyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-[(tetrahydro-2-furanyl)methyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(2,2-dimethylpropyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-pentyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-(2-thienylmethyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-[2-(1-piperidinyl)ethyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-(phenylmethyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(2,3-dihydroxypropyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-[[3-(trifluoromethoxy)phenyl]methyl]-;    piperazine, 1-acetyl-4-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]carbonyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-(2,2,2-trifluoroethyl)-;    butanoic acid, 4-[[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]carbonyl]amino]-, ethyl ester;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N,8-dimethyl-5-(methylamino)-N-2-propenyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-(2-pyridinylmethyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-cyclohexyl-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(trans-4-hydroxycyclohexyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-(tetrahydro-2-oxo-3-thienyl)-;    cyclopropanecarboxylic acid, 1-[[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]carbonyl]amino]-, methyl ester;    serine, N-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]carbonyl]-, methyl ester;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[4-(diethylamino)-1-methylbutyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N,8-dimethyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-ethyl-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-2-propynyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(3,3-dimethylbutyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(2-hydroxy-1-methylethyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(2-hydroxypropyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[2-(2-hydroxyethoxy)ethyl]-8-methyl-5-(methyl amino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(3-methoxypropyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[2-(acetylamino)ethyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-cyclopentyl-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(cyclohexylmethyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-[3-(4-morpholinyl)propyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-(2-furanylmethyl)-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[3-(1H-imidazol-1-yl)propyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[(3-fluorophenyl)methyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[(4-fluorophenyl)methyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[(3,4-difluorophenyl)methyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, N-[2-(3-fluorophenyl)ethyl]-8-methyl-5-(methylamino)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine-2-carboxamide, 8-methyl-5-(methylamino)-N-[(5-methyl-2-furanyl)methyl]-;    L-alanine, N-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]carbonyl]-, 1,1-dimethylethyl ester;    glycine, N-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]carbonyl]-, 1,1-dimethylethyl ester;    N-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzamide;    8-Methyl-2-(pyrazol-1-yl)-N-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8-Methyl-N-methyl-2-amino-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8-Methyl-2-(4-fluorophenyl)-N-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(4-pyridinyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(2-thienyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(4-quinolinyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-methoxyphenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[4-(trifluoromethyl)phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3-methoxyphenyl)-N,8-dimethyl-;    N-[1-[2-Fluoro-5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]acetamide;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(6-fluoro-3-pyridinyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(2-thiazolyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(2-pyridinyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3,6-dihydro-2H-thiopyran-4-yl)-N, 8-dimethyl-;    8-Methyl-N-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8-Methyl-N-methyl-2-(4-methoxyphenyl)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8-Methyl-2-(4-fluorophenyl)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8-Methyl-N-methyl-2-ethoxy-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N,8-dimethyl-2-[2-(4-morpholinyl)ethoxy]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N,8-Dimethyl-2-[pentyloxy]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(cyclohexyloxy)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(cyclopentyloxy)-N,8-dimethyl-;    1-propanol, 3-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]oxy]-;    1-butanol, 4-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]oxy]-;    1-pentanol, 5-[[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]oxy]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(cyclopropylmethoxy)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(2-methoxyethoxy)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3-methoxy-3-methylbutoxy)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(2-pyridinylmethoxy)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[(1-methyl-2-piperidinyl)methoxy]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(2-methylpropoxy)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(cyclobutylmethoxy)-N,8-dimethyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[2-(dimethylamino)ethoxy]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(phenylmethoxy)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-propoxy-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(1-methylethoxy)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-methoxy-N,8-dimethyl-N-Ethyl-2-(4-fluorophenyl)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N-cyclopropyl-2-(4-fluorophenyl)-8-methyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-fluorophenyl)-8-methyl-N-[2-(1-pyrrolidinyl)ethyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-fluorophenyl)-8-methyl-N-(4-piperidinylmethyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-fluorophenyl)-8-methyl-N-[2-(4-morpholinyl)ethyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-fluorophenyl)-8-methyl-N-(3-pyridinylmethyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-fluorophenyl)-8-methyl-N-[2-(1-piperidinyl)ethyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-fluorophenyl)-8-methyl-N-(1-methylethyl)-;    acetamide, N-[2-[[2-(4-fluorophenyl)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-yl]amino]ethyl]-;    1,2-ethanediamine, N-[2-(4-fluorophenyl)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-yl]-N′-methyl-;    ethanol, 2-[[2-[[2-(4-fluorophenyl)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-yl]amino]ethyl]amino]-;    1,2-ethanediamine, N′-[2-(4-fluorophenyl)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-yl]-N,N-dimethyl-;    ethanol, 2-[[2-(4-fluorophenyl)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-yl]amino]-;    N-methyl-N′-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]urea;    2-(4-Fluorophenyl)-N-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N-[1-[2-fluoro-5-[5-[(2-hydroxyethyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]acetamide;    acetamide, N-[1-[2-fluoro-5-[5-[[(4-methoxyphenyl)methyl]amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]-;    acetamide, N-[1-[5-[5-[[2-(acetylamino)ethyl]amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[2-fluoro-5-[8-methyl-5-[[2-(1-piperidinyl)ethyl]amino]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]-;    acetamide, N-[1-[5-[5-[[2-(dimethylamino)ethyl]amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[5-[5-(cyclopropylamino)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[2-fluoro-5-[8-methyl-5-[(1-methylethyl)amino]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]-;    acetamide, N-[1-[5-[5-(ethylamino)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[5-[5-[(2-aminoethyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[5-[5-[(2-diethylaminoethyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[5-[5-[(1-ethylpyrrolidin-2yl)methylamino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[5-[5-[(2-(2-azaindan-2-yl)ethyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[5-[5-[(3-dimethylaminopropyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[5-[5-[(3-imidazol-1-ylpropyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    acetamide, N-[1-[5-[5-[(3-piperidin-1-ylpropyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-2-fluorophenyl]ethyl]-;    2-(3-(2-carboxyethenyl)phenyl)-N-(2-aminoethyl)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    3-[8-methyl-5-[[2-(1-piperidinyl)ethyl]amino]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzeneacetonitrile;    benzeneacetonitrile, 3-[5-[(2-aminoethyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    2-propenoic acid, 3-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]-, (2E)-;    2-propenoic acid, 3-[3-[5-[[2-(acetylamino)ethyl]amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]-, (2E)-;    benzeneacetonitrile, 3-[5-[[2-(dimethylamino)ethyl]amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzeneacetonitrile, 3-[5-[(2-hydroxyethyl)amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzeneacetonitrile, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzeneacetonitrile, 3-[5-[[(4-methoxyphenyl)methyl]amino]-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzeneacetonitrile, 3-[8-methyl-5-[[2-(1-piperidinyl)ethyl]amino]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    benzeneacetonitrile, 3-[5-(ethylamino)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    2-Fluoro-5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzonitrile;    2-(3-Amino-1,2-benzisoxazol-5-yl)-N,8-dimethyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N,8-dimethyl-2-[3-[1-(methylamino)ethyl]phenyl]-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    benzenepropanoic acid, 4-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3,5-difluorophenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(1H-indol-5-yl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[3-(methylthio)phenyl]-;    benzonitrile, 3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(2-fluoro-3-pyridinyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(4-methyl-2-thienyl)-;    2-[3-(aminomethyl)phenyl]-N,8-dimethyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N-[[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]acetamide;    N-[[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]methanesulfonamide;    2-[3-(1-aminoethyl)phenyl]-N,8-dimethyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine;    N-[1-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]acetamide;    N-[1-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]methanesulfonamide;    N-[1-methyl-1-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]amine;    N-[1-methyl-1-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]ethyl]acetamide;    N-[1,1-dimethyl-1-[3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]4-fluorophenyl]ethyl]amine;    N-[1-[2-fluoro-5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]-1-methylethyl]-acetamide;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3-aminophenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-chlorophenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[4-(methylthio)phenyl]-;    benzaldehyde, 4-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-(3-thienyl)-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(2-benzofuranyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3-fluorophenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(2-methoxyphenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(3-fluoro-4-methoxyphenyl)-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[4-(dimethylamino)phenyl]-N,8-dimethyl-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[4-(trifluoromethoxy)phenyl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-(4-aminophenyl)-N,8-dimethyl-;    2-furanmethanol, 5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]-;    8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, N,8-dimethyl-2-[5-[(methylamino)methyl]-2-furanyl]-;    N,8-dimethyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-amine, 2-[3-(aminomethyl)-4-fluorophenyl];    N-[[2-fluoro-5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]acetamide;    N-[[2-fluoro-5-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]methanesulfonamide;    alpha-methyl-3-[8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl]benzenemethanol;    ethanol, 2-[(8-methyl-2-phenyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-yl)amino]-;    1,2-ethanediamine, N-(8-methyl-2-phenyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-yl)-; and    1,2-ethanediamine, N-[2-(4-fluorophenyl)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-5-yl]-.    
     
     
         15 . A pharmaceutical composition comprising (a) at least one compound according to  claim 1 , or a pharmaceutically acceptable salt, hydrate or prodrug thereof, and (b) a pharmaceutically-acceptable carrier or diluent.  
     
     
         16 . A method of treating an inflammatory or immune disease or disorder comprising administering to a mammal in need thereof a therapeutically-effective amount of at least one compound according to  claim 1 .  
     
     
         17 . The method of  claim 16  in which the inflammatory or immune disease is selected from rheumatoid arthritis, asthma, inflammatory bowel disease, chronic obstructive pulmonary disease, and psoriasis.  
     
     
         18 . A method of treating cancer comprising administering to a mammal in need thereof a therapeutically-effective amount of at least one compound according to  claim 1 .  
     
     
         19 . A compound of formula (II),  
       
         
           
           
               
               
           
         
         enantiomers, diastereomers, salts, and solvates thereof wherein  
         R 1  is selected from hydrogen, C 1 -3 alkyl, C 2 -3 alkenyl, and C 2 -3 alkynyl;  
         R 2  is hydrogen, halo, cyano, 
 (b) alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, cycloalkoxy, heterocyclooxy, aryloxy, heteroaryloxy, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1a , Z 2a  and Z 3a ; or  
 (c) —OR 10a , —SR 10a , or —SO 2 R 10a ;  
 
         R 5 , at each occurrence, is independently selected from F, Cl, Br, and I;  
         R 10a , at each occurance, are independently alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl any of which may be optionally independently substituted as valence allows with one or more Z 1d , Z 2d  and Z 3d ;  
         Z 1a-1e , Z 2a-2e , and Z 3a-3e  are optional substituents at each occurrence independently selected from —W 1 —V 1 ; —W 2 —V 2 ; —W 3 —V 3 ; —W 4 —V 4 ; —W 5 —V 5 ;  
         where W 1-5  are independently 
 (1) a bond  
 (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl; or  
 
         where V 1-5  are independently 
 (1) H  
 (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl;  
 (3) —U 1 —O—Y 5 ,  
 (4) —U 1 —S—Y 5 ,  
 (5) —U 1 —C(O) t —H, —U 1 —C(O) t —Y 5  where t is 1 or 2,  
 (6) —U 1 —SO 3 —H, or —U 1 —S(O) t Y 5 ,  
 (7) —U 1 -halo,  
 (8) —U 1 -cyano,  
 (9) —U 1 -nitro,  
 (10) —U 1 —NY 2 Y 3 ,  
 (11) —U 1 —N(Y 4 )—C(O)—Y 1 ,  
 (12) —U 1 —N(Y 4 )—C(S)—Y 1 ,  
 (13) —U 1 —N(Y 4 )—C(O)—NY 2 Y 3 ,  
 (14) —U 1 —N(Y 4 )—C(S)—NY 2 Y 3 ,  
 (15) —U 1 —N(Y 4 )—C(O)O—Y 5 ,  
 (16) —U 1 —N(Y 4 )—S(O) 2 —Y 1 ,  
 (17) —U 1 —N(Y 4 )—S(O) 2 —NY 2 Y 3 ,  
 (18) —U 1 —C(O)—NY 2 Y 3 ,  
 (19) —U 1 —OC(O)—NY 2 Y 3    
 (20) —U 1 —S(O) 2 —N(Y 4 )—Y 1 ,  
 (21) —U 1 —N(Y 4 )—C(═NV 1a )—NY 2 Y 3 ,  
 (22) —U 1 —N(Y 4 )—C(═NV 1a )—Y 1 ,  
 (23) —U 1 —C(═NV 1a )—NY 2 Y 3 ,  
 (24) oxo;  
 (25) —U 1 —Y 5 ;  
 
         V 1a  is independently hydrogen, alkyl, —CN, —C(O)Y 1 , —S(O) 2 Y 5 , S(O) 2 NY 2 Y 3 ;  
         Y 1 , Y 2 , Y 3 , Y 4  and Y 5  
 (1) are each independently hydrogen, alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocylco)alkyl, heteroaryl, or (heteroaryl)alkyl, any of which may be optionally independently substituted as valence allows with one or more Z 4 , Z 5  and Z 6 ; or  
 (2) Y 2  and Y 3  may together be alkylene or alkenylene, completing a 3- to 8-membered saturated or unsaturated ring together with the atoms to which they are attached, or  
 (4) Y 2  and Y 3  together with the nitrogen atom to which they are attached may combine to form a group —N═CY 6 Y 7  where Y 6  and Y 7  are each independently H or alkyl; and  
 
         Z 4 , Z 5 , and Z 6  are optional substituents at each occurrence independently selected from 
 (1) H  
 (2) alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, or (heteroaryl)alkyl;  
 (3) —U 1 —OY 5a ,  
 (4) —U 1 —S—Y 5a ,  
 (5) —U 1 —C(O) t —H, —U 1 —C(O) t —Y 5a  where t is 1 or 2,  
 (6) —U 1 —SO 3 —H, or —U 1 —S(O) t Y 5a ,  
 (7) —U 1 -halo,  
 (8) —U 1 -cyano,  
 (9) —U 1 -nitro,  
 (10) —U 1 —NY 2a Y 3a ,  
 (11) —U 1 —N(Y 4a )—C(O)—Y 1a ,  
 (12) —U 1 —N(Y 1a )—C(S)—Y 1a ,  
 (13) —U 1 —N(Y 4a )—C(O)—NY 2a Y 3a ,  
 (14) —U 1 —N(Y 4a )—C(S)—NY 2a Y 3a ,  
 (15) —U 1 —N(Y 4a )—C(O)O—Y 5a ,  
 (16) —U 1 —N(Y 4a )—S(O) 2 —Y 1a ,  
 (17) —U 1 —N(Y 4a )—S(O) 2 —NY 2a Y 3a ,  
 (18) —U 1 —C(O)—NY 2a Y 3a ,  
 (19) U 1 —OC(O)—NY 2a Y 3a    
 (20) —U 1 —S(O) 2 —N(Y 4a )—Y 1a ,  
 (21) —U 1 —N(Y 4a )—C(═NV 1a )—NY 2a Y 3a ,  
 (22) —U 1 —N(Y 4a )—C(═NV 1a )—Y 1a ,  
 (23) —U 1 —C(═NV 1a )—NY 2a Y 3a ,  
 (24) oxo;  
 (25) —U 1 —Y 5a ;  
 
         Y 1a , Y 2a , Y 3a , Y 4a  and Y 5a  
 (1) are each independently hydrogen, alkyl, (hydroxy)alkyl, (alkoxy)alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, (aryl)alkyl, heterocyclo, (heterocylco)alkyl, heteroaryl, or (heteroaryl)alkyl;  
 
         U 1  is independently 
 (1) a single bond,  
 (2) alkylene,  
 (3) alkenylene, or  
 (4) alkynylene.  
 
       
     
     
         20 . A compound of formula (III),  
       
         
           
           
               
               
           
         
         enantiomers, diastereomers, salts, and solvates thereof wherein  
         R 1  is selected from hydrogen, C 1 -3 alkyl, C 2 -3 alkenyl, and C 2 -3 alkynyl; and  
         R 5 , at each occurrence, is independently selected from F, Cl, Br, and I.