US2006223987A1PendingUtilityA1

Novel beta-defensins

61
Individually held — no corporate assignee on recordPriority: Sep 10, 1997Filed: Jun 9, 2006Published: Oct 5, 2006
Est. expirySep 10, 2017(expired)· nominal 20-yr term from priority
Inventors:David AdlerJames HollowayNand BaindurStephanie Beigel-OrmePaul O. Sheppard
C07K 14/4723A61P 37/00A61K 38/00Y02A50/30
61
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Claims

Abstract

The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.

Claims

exact text as granted — not AI-modified
1 . A purified antibody which specifically binds to a polypeptide consisting of an amino acid sequence that is at least 95% identical to amino acid residues 23 to 67 of SEQ ID NO:10.  
     
     
         2 . The antibody of  claim 1  wherein the polypeptide consists of amino acid residues 23 to 67 of SEQ ID NO:10.  
     
     
         3 . The antibody of  claim 1  wherein the antibody is a polyclonal antibody.  
     
     
         4 . The antibody of  claim 1  wherein the antibody is a monoclonal antibody.  
     
     
         5 . The antibody of  claim 1  wherein the antibody is an antibody fragment.  
     
     
         6 . The antibody of  claim 5  wherein the antibody fragment is F(ab′) 2 .  
     
     
         7 . The antibody of  claim 5  wherein the antibody fragment is Fab.  
     
     
         8 . The antibody of  claim 5  wherein the antibody fragment is Fv.  
     
     
         9 . The antibody of  claim 5  wherein the antibody fragment is a single chain antibody.  
     
     
         10 . The antibody of  claim 1  wherein the antibody is a chimeric antibody.  
     
     
         11 . The antibody of  claim 1  wherein the antibody is a humanized antibody.  
     
     
         12 . A method of producing an antibody comprising: 
 inoculating an animal with a polypeptide, wherein the polypeptode consists amino acid residues 23 to 67 of SEQ ID NO:10, and wherein the polypeptide elicits an immune response in the animal to produce the antibody; and    isolating the antibody from the animal.    
     
     
         13 . The antibody produced by the method of  claim 12  wherein the antibody binds to the polypeptide consisting amino acid residues 23 to 67 of SEQ ID NO:10.  
     
     
         14 . The antibody produced by the method of  claim 12  wherein the antibody is a polyclonal antibody.

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