Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof

Abstract

The invention is in the area of pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof. In particular, the invention includes isolated adipose tissue derived stromal cells that have been induced to express at least one phenotypic characteristic of a neuronal, astroglial, hematopoietic progenitor, or hepatic cell. The invention also includes an isolated adipocyte tissue-derived stromal cell that has been dedifferentiated such that there is an absence of adipocyte phenotypic markers.

1 - 3 . (canceled)  
   
   
       4 . An isolated adipose tissue derived stromal cell that has been induced to express at least one characteristic of a hepatic cell.  
   
   
       5 . (canceled)  
   
   
       6 . The cell of  claim 4 , wherein at least one non-endogenous nucleic acid sequence has been introduced into the cell.  
   
   
       7 - 43 . (canceled)  
   
   
       44 . A composition that includes an adipose tissue derived stromal cell that has been induced to express at least one characteristic of a hepatic derived cell wherein at least one non-endogenous nucleic acid sequence has been introduced into the stromal cell, in combination with a pharmaceutically acceptable carrier.  
   
   
       45 - 47 . (canceled)  
   
   
       48 . An isolated adipose tissue derived stromal cell that has been induced to express at least one characteristic of a hepatic cell in a two or three dimensional framework suitable for implantation into a host.