Tocopherol-modified therapeutic drug compounds

Abstract

Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.

1 . Tocopherol succinate paclitaxel.  
     
     
         2 . A method for treating a cell proliferative disease, comprising administering to a subject in need thereof a therapeutically effective amount of tocopherol succinate paclitaxel.  
     
     
         3 . A method for treating a cell proliferative disease, comprising administering to a subject in need thereof an emulsion comprising: 
 (a) an oil phase comprising 
 (i) tocopherol succinate paclitaxel; and  
 (ii) a lipophilic medium; and  
   (b) an aqueous phase.    
     
     
         4 . The method of  claim 3 , wherein the lipophilic medium comprises a tocopherol.  
     
     
         5 . A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and tocopherol succinate paclitaxel.  
     
     
         6 . The composition of  claim 5 , wherein the pharmaceutically acceptable carrier comprises a lipophilic medium.  
     
     
         7 . The composition of  claim 5 , wherein the pharmaceutically acceptable carrier comprises a tocopherol.  
     
     
         8 . Tocopherol succinate docetaxel.  
     
     
         9 . A method for treating a cell proliferative disease, comprising administering to a subject in need thereof a therapeutically effective amount of tocopherol succinate docetaxel.  
     
     
         10 . A method for treating a cell proliferative disease, comprising administering to a subject in need thereof an emulsion comprising: 
 (a) an oil phase comprising 
 (i) tocopherol succinate docetaxel; and  
 (ii) a lipophilic medium; and  
   (b) an aqueous phase.    
     
     
         11 . The method of  claim 10 , wherein the lipophilic medium comprises a tocopherol.  
     
     
         12 . A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and tocopherol succinate docetaxel.  
     
     
         13 . The composition of  claim 12 , wherein the pharmaceutically acceptable carrier comprises a lipophilic medium.  
     
     
         14 . The composition of  claim 12 , wherein the pharmaceutically acceptable carrier comprises a tocopherol.