Non-Endocrine Disrupting Cytoprotective UV Radiation Resistant Substance

Abstract

Compositions for enhanced UV-protective agents that increase immuno-responsiveness by providing cytoprotective additives for mammalian skin by ensuring avoidance from endocrine disrupting agents are described. A composition comprising: (a) at least one inorganic non-endocrine disrupting sun-blocking agent or organic non-endocrine disrupting sunscreen agent, (b) at least one non-endocrine disrupting emollient or mixtures thereof and (c) an optional oil component comprising a carrier oil, preferably an essential oil of a naturally occuring substance and a method of making this and other embodiments of similar compositions of the same invention is detailed. Inorganic component (a) is titanium dioxide, zinc oxide, silica or silicon dioxide, fluoropolymers or mixtures thereof. Organic component (a) is butylmethoxy dibenzoylmethane. The non-endocrine disrupting component (b) is cold-processed Aloe barbadensis Miller, which contains a glucose-rich mannose-containing oligosaccharide or oligosaccharides, or a fatty acid salt such as sodium stearate. The compositions are shown to be capable of protecting skin and mammalian health from the harmful effects of radiation including ultraviolet light or sunlight by inhibiting the loss of skin immunocompetency and eliminating any known or suspected endocrine disrupting agents normally utilized as sun protective agents.

1 . A composition comprising: 
 (a) at least one inorganic, non-endocrine disrupting sun-blocking agent;    (b) at least one non-endocrine disrupting emollient or mixtures thereof;    and optionally;    (c) an oil component,    said composition capable of protecting skin from harmful effects of radiation including sunlight and ultraviolet light.    
     
     
         2 . The composition according to  claim 1  wherein said oil is a carrier oil, or an essential oil, or both, derived from an earth grown substance comprising no known endocrine disrupting agents.  
     
     
         3 . A composition according to  claim 1 , wherein said emollient is aloe barbadensis Miller.  
     
     
         4 . A composition according to  claim 3 , wherein said emollient includes oligosaccharides of  aloe barbadensis  Miller that inhibit loss of skin immuno-competency.  
     
     
         5 . A composition according to  claim 1 , wherein active sun-block agents, emollients, and carrier or essential oils or both include other non-endocrine disruptive agents comprising a sunless tanning agent, an anti-microbial agent, a de-pigmentation agent, an anti-aging agent, an anti-fungal agent, and an insect repellent or any combination thereof, and wherein one or more of said agents are topically active.  
     
     
         6 . A sun-block composition according to  claim 1 , wherein said inorganic sun-block agent is titanium dioxide, zinc oxide, silica or silicon dioxide, fluoropolymers, or mixtures thereof.  
     
     
         7 . A sun-block composition according to  claim 6  wherein said inorganic sun-block agent is zinc oxide.  
     
     
         8 . A sun-block composition according to  claim 7  wherein said zinc oxide has a primary particle size of less than about 30 nm.  
     
     
         9 . A sun-block composition according to claims  1 , wherein said emollient is a salt of a fatty acid, where said salt of said fatty acid has been determined to be non-endocrine disrupting.  
     
     
         10 . A sun-block composition according to claims  1  wherein said composition has a pH of at least of 5.  
     
     
         11 . A sun-block composition according to  claim 10  wherein said pH is from about 6.5 to about 8.5.  
     
     
         12 . A sun-block composition according to claims  1  having a Sun Protection Factor (SPF) of at least 10, and preferably an immuno-responsiveness factor (IRF) of greater than zero, and preferably a non-endocrine disrupter (NED) factor not greater than zero.  
     
     
         13 . A composition comprising: 
 (a) at least one organic, non-endocrine disrupting sunscreen agent;    (b) at least one non-endocrine disrupting emollient or mixtures thereof; and;    (c) a not essential inorganic, non-endocrine disrupting sun-block agent and;    (d) a not essential oil component comprising a carrier oil or an essential oil or both derived from an earth grown substance comprising no known endocrine disruptive agents;    said composition capable of protecting skin from harmful effects of radiation including ultraviolet light or sunlight.    
     
     
         14 . The composition according to  claim 13 , wherein said sunscreen agent is butylmethoxydibenzoylmethane.  
     
     
         15 . The composition according to  claim 14 , wherein said emollient is  aloe barbadensis  Miller.  
     
     
         16 . The composition according to  claim 15 , wherein said emollient includes oligosaccharides of  aloe barbadensis  Miller that inhibit loss of skin immunocompetency.  
     
     
         17 . The composition according to  claim 13 , wherein active sunscreen agents, emollients, and carrier oils may include other non-endocrine disruptive agents comprising a sunless tanning agent, an anti-microbial agent, a de-pigmentation agent, an anti-aging agent, an anti-fungal agent, and an insect repellent or any combination thereof, and wherein one or more of said agents are topically active.  
     
     
         18 . A sunscreen composition according to  claim 13  wherein said inorganic sun-block agent is titanium dioxide, zinc oxide, silica or silicon dioxide or mixtures thereof.  
     
     
         19 . A sunscreen composition according to  claim 18  wherein said inorganic sun-block agent is zinc oxide.  
     
     
         20 . A sunscreen composition according to  claim 19  wherein said zinc oxide has a primary particle size of less than or equal to 30 nannometers.  
     
     
         21 . A sunscreen composition according to  claim 20  wherein said emollient is a salt of a fatty acid, where said salt of said fatty acid has been determined to be non-endocrine disrupting.  
     
     
         22 . A sunscreen composition according to  claim 13 , wherein said composition has a pH of at least of 5.  
     
     
         23 . A sunscreen composition according to  claim 22 , wherein said pH is from about 6.5 to about 8.5.  
     
     
         24 . A sunscreen composition according to  claim 13  having a Sun Protection Factor (SPF) of at least 10, and preferably an immuno-responsiveness factor (IRF) of greater than zero, and preferably a non-endocrine disrupter (NED) factor not greater than zero.  
     
     
         25 . A sun-block composition according to  claim 1 , comprising; aloe vera, deionized water, micronized zinc oxide, glycerin, beeswax, ascorbyl vitamin C palmitate, an enzyme concentrate, rose oil, tocopheryl vitamin E acetate, retinyl vitamin A palmitate, ergocalciferol (vitamin D), xanthan gum, magnesium silicate, grapefruit seed extract, rosemary extract, cinnamon extract, and bearberry extract.  
     
     
         26 . A sun-block composition consisting of; aloe vera, deionized water, micronized zinc oxide, glycerin, beeswax, ascorbyl vitamin C palmitate, an enzyme concentrate, rose oil, tocopheryl vitamin E acetate, retinyl vitamin A palmitate, ergocalciferol (vitamin D), xanthan gum, magnesium silicate, grapefruit seed extract, rosemary extract, cinnamon extract, and bearberry extract.  
     
     
         27 . The composition of  claim 1 , wherein said composition contains between 2% and about 25% of an inorganic sun-block or sunscreen agent, from between 0.5% and about 10% of an emollient and from between 0.5% and about 10% of an oil component comprising a carrier oil where said carrier oil is a desirable essential oil derived from earth grown substances.  
     
     
         28 . The composition of  claim 13 , wherein said composition contains between 2% and about 25% of an inorganic sun-block or sunscreen agent, from between 0.5% and about 10% of an emollient and from between 0.5% and about 10% of an oil component comprising a carrier oil where said carrier oil is a desirable essential oil derived from earth grown substances.  
     
     
         29 . The composition of claims  27  or  28 , wherein the ratio of inorganic sun-block agent to oil component is from between 0:3 to about 1:1, or ratio of organic sunscreen agent to oil component is from between 0:3 to about 1:1 or ratio of the combination of both sun-block and sunscreen is from between 0:3 to about 1:1.  
     
     
         30 . The composition of claims  1  or  13 , wherein said compositions comprise any enzyme or enzyme mixture.  
     
     
         31 . The composition of  claim 27 , wherein said composition comprises; 
 (a) a cyto-protective agent deriving from an earth grown substance; and a composition containing at least one or more of the following additional substances;    (b) sunflower oil, vegetable glycerin, coconut oil, stearic acid as extracted from vegetable fat, beeswax, orange wax, tocopheryl acetate, buttermilk powder, sodium borate, xanthan gum, honey, sucrose stearate, glucose, glucose oxidase, lactoperoxidase, and rosemary extract and an essential oil containing fragrance.    
     
     
         32 . The composition of  claim 28 , wherein said composition comprises; 
 (a) a cyto-protective agent deriving from an earth grown substance; and a composition containing at least one or more of the following additional substances;    (b) sunflower oil, vegetable glycerin, coconut oil, stearic acid as extracted from vegetable fat, beeswax, orange wax, tocopheryl acetate, buttermilk powder, sodium borate, xanthan gum, honey, sucrose stearate, glucose, glucose oxidase, lactoperoxidase, and rosemary extract and an essential oil containing fragrance.    
     
     
         33 . A method of protecting mammalian skin from harmful effects of ultraviolet-A and ultraviolet-B radiation and enhancing skin immunocompetency comprising topically applying to said skin an effective amount of a UV-protective composition, said composition comprising; 
 (a) at least one non-endocrine disrupting sun-block or sunscreen active agent in an amount effective to protect said skin against actinic radiation from sunlight; wherein said sun-block agents include zinc oxide or titanium dioxide and said sunscreen agents include butyl-methoxydibenzoylmethane;    (b) non-endocrine disruptive and cytoprotective mixtures made of substances that are grown from the earth, at least one of said mixtures comprising a glucose-rich mannose-containing oligosaccharide or oligosaccharides obtained from cold processed aloe barbadensis Miller 
 and not essential components including;  
   (c) sunflower oil, vegetable glycerin, coconut oil, stearic acid as extracted from vegetable fat, beeswax, orange wax, tocopheryl acetate, buttermilk powder, sodium borate, xanthan gum, sucrose stearate, glucose, glucose oxidase, lactoperoxidase, and rosemary extract and an essential oil containing fragrance; 
 and;  
   (d) sufficient filtered water to form an emulsion.    
     
     
         34 . A method of protecting mammalian skin from harmful effects of ultraviolet-A and ultraviolet-B radiation and enhancing skin immunocompetency comprising topically applying to said skin an effective amount of a UV-protective composition, said composition comprising; 
 (e) at least one non-endocrine disrupting sun-block or sunscreen active agent in an amount effective to protect said skin against actinic radiation from sunlight; wherein said sun-block agents include zinc oxide or titanium dioxide and said sunscreen agents include butyl-methoxydibenzoylmethane;    (f) non-endocrine disruptive and cytoprotective mixtures made of substances that are grown from the earth, at least one of said mixtures comprising a glucose-rich mannose-containing oligosaccharide or oligosaccharides obtained from cold processed aloe barbadensis Miller 
 and required components including;  
   (g) sunflower oil, vegetable glycerin, coconut oil, stearic acid as extracted from vegetable fat, beeswax, orange wax, tocopheryl acetate, buttermilk powder, sodium borate, xanthan gum, sucrose stearate, glucose, glucose oxidase, lactoperoxidase, and rosemary extract and an essential oil containing fragrance; 
 and;  
   (h) sufficient filtered water to form an emulsion.    
     
     
         35 . The method of claims  33  or  34 , wherein said composition comprises any enzyme or enzyme mixture.  
     
     
         36 . The method of claims  33  or  34 , wherein said composition comprises from about 0.0001% to about 10% (w/w) of said non-endocrine disrupting agents and said cytoprotective agents.  
     
     
         37 . The method of claims  33  or  34 , wherein said composition comprises about 0.01% to about 1% (w/w) of said non-endocrine disrupting agents and said cytoprotective agents.  
     
     
         38 . The method of claims  33  or  34 , wherein said composition comprises about 0.1% to about 0.5% (w/w) of said non-endocrine disrupting agents and said cytoprotective agents.  
     
     
         39 . The method of claims  33 - 38 , wherein said composition is formulated into a solid, a liquid, an aerosol, a cream, a lotion, an ointment, a microemulsion, a solution, or a gel form.  
     
     
         40 . The method of claims  33  or  34 , wherein said sunscreen agent comprises non-endocrine disrupting agents consisting of butyl-methoxydibenzoylmethane and other dibenzoyl etheric.  
     
     
         41 . The method of  claim 40 , wherein any or all said agents are immunoenhancing.  
     
     
         42 . The method of  claim 41 , wherein any or all said agents are cytoprotecting.  
     
     
         43 . The method of claims  33  or  34 , wherein said sun-block agent is selected from the group consisting of; zinc oxide and titanium dioxide or zinc oxide or titanium dioxide individually.  
     
     
         44 . A method of protecting mammalian skin from harmful effects of ultraviolet-A and ultraviolet-B radiation and enhancing skin immunocompetency comprising topically applying to said skin an effective amount of a UV-protective composition, said composition comprising; 
 (a) at least one sun-block or sunscreen active agent in an amount effective to protect said skin against actinic radiation from sunlight;    (b) agents of said UV-protective compositions free of any known or suspected endocrine disrupters;    (c) a non-endocrine disruptive, cytoprotective mixture made of earth grown substances, said mixture comprising glucose-rich mannose-containing oligosaccharide or oligosaccharides obtained from and used with aloe barbadensis Miller processed at or below room temperature within 45 minutes of harvesting, 
 and;  
 not essential components including;  
   (d) aminoacids, vitamins or provitamins, nucleoderivatives, and vegetable extracts, wherein said aminoacids comprise tryptophan, histidine, phenylalanine, tyrosine, said vitamins and provitamins comprise vitamin B6, vitamin A, vitamin E, tocopherols, betacarotene, bioflavonoids, nucleotides and polymers thereof, cascara, frangula, camomile, hyperic, calendula, elicriso, licorice or essential oils thereof, and;    (e) enough water to form a well mixed emulsion.    
     
     
         45 . A method of protecting mammalian skin from harmful effects of ultraviolet-A and ultraviolet-B radiation and enhancing skin immunocompetency comprising topically applying to said skin an effective amount of a UV-protective composition, said composition comprising; 
 (a) at least one sunscreen or sun-block active agent in an amount effective to protect said skin against actinic radiation from sunlight;    (b) agents of said UV-protective compositions free of any known or suspected endocrine disrupters;    (c) a non-endocrine disruptive, cytoprotective mixture made of earth grown substances, said mixture comprising a glucose-rich mannose-containing oligosaccharide or oligosaccharides obtained from and used with aloe barbadensis Miller that can function as the at least one emollient, and;    (d) enough water to form a well mixed emulsion.    
     
     
         46 . The method of claims  44  or  45 , wherein said compositions comprise any enzyme or enzyme mixture.  
     
     
         47 . A method of making a UV-protective composition comprising; 
 (a) adding de-ionized water, cold pressed aloe, and zinc oxide or titanium dioxide or both in combination to a vessel;    (b) then, adding a carrier oil;    (c) then, mixing said resultant composition in said vessel.    
     
     
         48 . The method of  claim 47 , comprising the steps of; 
 (a) adding de-ionized water, cold pressed aloe, and zinc oxide or titanium dioxide or both in combination to a vessel;    (b) then, adding a carrier oil and an emollient other than cold pressed aloe to said vessel;    (c) then, mixing said resultant composition;    (d) maintaining (a)-(c) at or below 80 F, then, maintaining or adjusting the pH of said composition to above 5.    
     
     
         49 . The method of  claim 48 , comprising the steps of; 
 (a) adding de-ionized water, cold pressed aloe, and zinc oxide or titanium dioxide or both in combination to a vessel;    (b) then, adding a carrier oil and an emollient other than cold pressed aloe, and a thickener to said vessel;    (c) then, mixing said resultant composition;    (d) maintaining (a)-(c) at or below 80 F, then, maintaining or adjusting the pH of said composition to above 5.    
     
     
         50 . The method of  claim 50 , wherein said UV-protective composition is also non-endocrine disrupting, cytoprotecting, and immuno-enhancing.