Biocompatible materials and probes

Abstract

The present invention relates to fluorinated biopolymer and polymer derivatives useful as imaging probes, diagnostic agents and contrast agents and to imaging methods employing the fluorinated biopolymers and polymers.

1 . A fluorinated biopolymer of the Formula XIII  
     
       
         
         
             
             
         
       
     
     where 
 for Formula XIII:  
 K represents H, OH, X, OX, OZ, (Y) f ; L represents H, OH, X, OX, OZ, (Y) f ; W represents H, (CH 2 ) d , CO 2 H, CH, CX, X; T represents H, OH, X, OX, OZ; V represents (CH 2 ) d , CH 2 OX, CH 2 OZ, CH 2 X, CH 2 NHX; S represents H, O, X, NHX, (Y) f ; T represents H, O, X, NHX, (Y) f ; R 1  represents H, X and d represents 1-3 inclusive; f, and n represent 1-1,500 inclusive and for all of the above Formulas:  
 X represents a fluorine containing moiety, a luminescent residue, a fluorescent residue, a fluorinated luminescent residue or a fluorinated fluorescent residue;  
 Y represents an amino acid residue or a fluorinated amino acid residue; and  
 Z represents acyl, alkyl.  
 
   
   
       2 . The fluorinated biopolymer of any of  claim 1 , wherein X is fluoroalkyl, fluoroaryl, fluoroacyl, perfluoroalkyl, perfluoroaryl, perfluoroacyl, perfluoropolymer, fluoroamine, fluorocarbamate, fluorotriazine, fluorosulfonylalkyl derivatives, CF 2 Cl, SO 2 [CF 2 ] x CF 3 , F, CF 3 , COC x F y , C x F y H z , ([CH 2 ] m O) x (CH 2 CF 2 O) y (CF 2 CF 2 O) z (CF 2 ) 2 CF 2 CH 2 O(CH 2 ) p OH, CH 2 C(OH)C x F y H z , C x F y H z O p , COC x F y H z , OCH 2 C x F z [C x F z O] m F, CH 2 C(CH 3 )CO 2 C x H z (CF 2 ) m CF 3 , CH 2 (CF 2 O) x (CF 2 CF 2 O) y (CF 2 O) z CF 2 CH 2 OH, COCF(CF 3 )—[CF(CF 3 )CF 2 O] m F, NHC x F y H z O p , CH 2 CF 2 O[CF 2 CF 2 O] m (CF 2 OCF 2 CH 2 OH, COC x H z (CF 2 ) m CF 3 , COCF 2 O[CF 2 CF 2 O] n CF 2 OCF 2 CO 2 H, ([CH 2 ] m O) x (CH 2 CF 2 O) y (CF 2 CF 2 O) z CF 2 CH 2 O(CH 2 ) p OH, N[C x F y H z ] p , C x H z CO 2 C x H z (CF 2 ) m CF 3 , COC x F y [C p F z O] m F, and m, x, p, y, z are integers from 1 to 150 inclusive.  
   
   
       3 . A method of improving the effectiveness of magnetic resonance imaging (MRI) which comprises: 
 a. administering an effective amount of one or more fluorinated polymers of  claim 1 , to a patient;    b. subjecting the patient to an MRI of a tissue/organ where the administered polymer is expected to accumulate; and    c. evaluating the tissue/organ from the MRI images obtained.