US2006240064A9PendingUtilityA9

Medical implants and fibrosis-inducing agents

Assignee: ANGIOTECH INT AGPriority: Nov 10, 2003Filed: Dec 1, 2004Published: Oct 26, 2006

Est. expiryNov 10, 2023(expired)· nominal 20-yr term from priority

Inventors:William L. Hunter David Gravett Philip M. Toleikis Arpita Maiti Pierre Signore Richard Liggins Dechi Guan

A61P 9/00A61P 43/00A61L 2300/412A61K 45/06A61P 1/00A61B 17/1219A61K 38/4833A61B 17/12099A61F 2250/0067A61K 38/38A61K 38/363A61P 19/00A61B 17/12168A61B 17/1214A61B 17/12022A61L 2430/38A61B 17/68A61B 17/12186A61L 27/54A61K 38/39A61B 17/11A61B 17/12109A61L 31/16A61L 2300/00

PatentIndex Score

Cited by

References

Claims

Abstract

Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue.

Claims

exact text as granted — not AI-modified

1 - 1791 . (canceled)

1792 . A method comprising introducing into a patient in need thereof, a therapeutically effective amount of a fibrosing agent or a composition comprising a fibrosing agent, where the fibrosing agent induces a fibrotic response at a specific site within the patient, thereby providing the patient with treatment for an orthopedic condition.

1793 . (canceled)

1794 . The method of claim 1792 wherein the agent promotes angiogenesis.

1795 . The method of claim 1792 wherein the agent promotes fibroblast migration.

1796 . The method of claim 1792 wherein the agent promotes fibroblast proliferation.

1797 . The method of claim 1792 wherein the agent promotes deposition of extracellular matrix (ECM).

1798 . The method of claim 1792 wherein the agent promotes tissue remodeling.

1799 . The method of claim 1792 wherein the agent is an arterial vessel wall irritant.

1800 . The method of- claim 1792 wherein the fibrosing agent is or comprises silk.

1801 .- 1805 . (canceled)

1806 . The method of claim 1792 wherein the fibrosing agent is or comprises bleomycin.

1807 .- 1829 . (canceled)

1830 . The method of claim 1792 , wherein the composition further comprises a second pharmaceutically active agent.

1831 . (canceled)

1832 . The method of claim 1792 , wherein the composition further comprises an agent that inhibits infection.

1833 .- 2027 . (canceled)

2028 . A medical device comprising an orthopedic implant and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

2029 . (canceled)

2030 . The device of claim 2028 wherein the fibrosing agent promotes angiogenesis.

2031 . The device of claim 2028 wherein the fibrosing agent promotes fibroblast migration.

2032 . The device of claim 2028 wherein the fibrosing agent promotes fibroblast proliferation.

2033 . The device of claim 2028 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

2034 . The device of claim 2028 wherein the fibrosing agent promotes tissue remodeling.

2035 . The device of claim 2028 wherein the fibrosing agent is an arterial vessel wall irritant.

2036 . (canceled)

2037 . (canceled)

2038 . The device of claim 2028 wherein the fibrosing agent is or comprises silk.

2039 .- 2042 . (canceled)

2043 . The device of claim 2028 wherein the fibrosing agent is or comprises bleomycin.

2044 .- 2099 . (canceled)

2100 . The device of claim 2028 , further comprising a second pharmaceutically active agent.

2101 . (canceled)

2102 . The device of claim 2028 , further comprising an agent that inhibits infection.

2103 .- 2154 . (canceled)

2155 . A medical device comprising an orthopedic prosthesis and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

2156 . (canceled)

2157 . The device of claim 2155 wherein the fibrosing agent promotes angiogenesis.

2158 . The device of claim 2155 wherein the fibrosing agent promotes fibroblast migration.

2159 . The device of claim 2155 wherein the fibrosing agent promotes fibroblast proliferation.

2160 . The device of claim 2155 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

2161 . The device of claim 2155 wherein the fibrosing agent promotes tissue remodeling.

2162 . The device of claim 2155 wherein the fibrosing agent is an arterial vessel wall irritant.

2163 . (canceled)

2164 . (canceled)

2165 . The device of claim 2155 wherein the fibrosing agent is or comprises silk.

2166 .- 2169 . (canceled)

2170 . The device of claim 2155 wherein the fibrosing agent is or comprises bleomycin.

2171 .- 2226 . (canceled)

2227 . The device of claim 2155 , further comprising a second pharmaceutically active agent.

2228 . (canceled)

2229 . The device of claim 2155 , further comprising an agent that inhibits infection.

2230 .- 4144 . (canceled)

4145 . A medical device comprising an internal fixation implant and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

4146 . (canceled)

4147 . The device of claim 4145 wherein the fibrosing agent promotes angiogenesis.

4148 . The device of claim 4145 wherein the fibrosing agent promotes fibroblast migration.

4149 . The device of claim 4145 wherein the fibrosing agent promotes fibroblast proliferation.

4150 . The device of claim 4145 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

4151 . The device of claim 4145 wherein the fibrosing agent promotes tissue remodeling.

4152 . The device of claim 4145 wherein the fibrosing agent is an arterial vessel wall irritant.

4153 . (canceled)

4154 . (canceled)

4155 . The device of claim 4145 wherein the fibrosing agent is or comprises silk.

4156 .- 4159 . (canceled)

4160 . The device of claim 4145 wherein the fibrosing agent is or comprises bleomycin.

4161 .- 4216 . (canceled)

4217 . The device of claim 4145 , further comprising a second pharmaceutically active agent.

4218 . (canceled)

4219 . The device of claim 4145 , further comprising an agent that inhibits infection.

4220 .- 4268 . (canceled)

4269 . A medical device comprising an external fixation implant and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

4270 . (canceled)

4271 . The device of claim 4269 wherein the fibrosing agent promotes angiogenesis.

4272 . The device of claim 4269 wherein the fibrosing agent promotes fibroblast migration.

4273 . The device of claim 4269 wherein the fibrosing agent promotes fibroblast proliferation.

4274 . The device of claim 4269 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

4275 . The device of claim 4269 wherein the fibrosing agent promotes tissue remodeling.

4276 . The device of claim 4269 wherein the fibrosing agent is an arterial vessel wall irritant.

4277 . (canceled)

4278 . (canceled)

4279 . The device of claim 4269 wherein the fibrosing agent is or comprises silk.

4280 .- 4283 . (canceled)

4284 . The device of claim 4269 wherein the fibrosing agent is or comprises bleomycin.

4285 .- 4340 . (canceled)

4341 . The device of claim 4269 , further comprising a second pharmaceutically active agent.

4342 . (canceled)

4343 . The device of claim 4269 , further comprising an agent that inhibits infection.

4344 .- 4392 . (canceled)

4393 . A medical device comprising a fixation screw and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

4394 . (canceled)

4395 . The device of claim 4393 wherein the fibrosing agent promotes angiogenesis.

4396 . The device of claim 4393 wherein the fibrosing agent promotes fibroblast migration.

4397 . The device of claim 4393 wherein the fibrosing agent promotes fibroblast proliferation.

4398 . The device of claim 4393 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

4399 . The device of claim 4393 wherein the fibrosing agent promotes tissue remodeling.

4400 . The device of claim 4393 wherein the fibrosing agent is an arterial vessel wall irritant.

4401 . (canceled)

4402 . (canceled)

4403 . The device of claim 4393 wherein the fibrosing agent is or comprises silk.

4404 .- 4407 . (canceled)

4408 . The device of claim 4393 wherein the fibrosing agent is or comprises bleomycin.

4409 .- 4464 . (canceled)

4465 . The device of claim 4393 , further comprising a second pharmaceutically active agent.

4466 . (canceled)

4467 . The device of claim 4393 , further comprising an agent that inhibits infection.

4468 .- 4518 . (canceled)

4519 . A medical device comprising an interferential screw and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

4520 . (canceled)

4521 . The device of claim 4519 wherein the fibrosing agent promotes angiogenesis.

4522 . The device of claim 4519 wherein the fibrosing agent promotes fibroblast migration.

4523 . The device of claim 4519 wherein the fibrosing agent promotes fibroblast proliferation.

4524 . The device of claim 4519 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

4525 . The device of claim 4519 wherein the fibrosing agent promotes tissue remodeling.

4526 . The device of claim 4519 wherein the fibrosing agent is an arterial vessel wall irritant.

4527 . (canceled)

4528 . (canceled)

4529 . The device of claim 4519 wherein the fibrosing agent is or comprises silk.

4530 .- 4533 . (canceled)

4534 . The device of claim 4519 wherein the fibrosing agent is or comprises bleomycin.

4535 .- 4590 . (canceled)

4591 . The device of claim 4519 , further comprising a second pharmaceutically active agent.

4592 . (canceled)

4593 . The device of claim 4519 , further comprising an agent that inhibits infection.

4594 .- 4644 . (canceled)

4645 . A medical device comprising a trochanteric screw and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

4646 . (canceled)

4647 . The device of claim 4645 wherein the fibrosing agent promotes angiogenesis.

4648 . The device of claim 4645 wherein the fibrosing agent promotes fibroblast migration.

4649 . The device of claim 4645 wherein the fibrosing agent promotes fibroblast proliferation.

4650 . The device of claim 4645 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

4651 . The device of claim 4645 wherein the fibrosing agent promotes tissue remodeling.

4652 . The device of claim 4645 wherein the fibrosing agent is an arterial vessel wall irritant.

4653 . (canceled)

4654 . (canceled)

4655 . The device of claim 4645 wherein the fibrosing agent is or comprises silk.

4656 .- 4659 . (canceled)

4660 . The device of claim 4645 wherein the fibrosing agent is or comprises bleomycin.

4661 .- 4716 . (canceled)

4717 . The device of claim 4645 , further comprising a second pharmaceutically active agent.

4718 . (canceled)

4719 . The device of claim 4645 , further comprising an agent that inhibits infection.

4720 .- 4768 . (canceled)

4769 . A medical device comprising a plate implant and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

4770 . (canceled)

4771 . The device of claim 4769 wherein the fibrosing agent promotes angiogenesis.

4772 . The device of claim 4769 wherein the fibrosing agent promotes fibroblast migration.

4773 . The device of claim 4769 wherein the fibrosing agent promotes fibroblast proliferation.

4774 . The device of claim 4769 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

4775 . The device of claim 4769 wherein the fibrosing agent promotes tissue remodeling.

4776 . The device of claim 4769 wherein the fibrosing agent is an arterial vessel wall irritant.

4777 . (canceled)

4778 . (canceled)

4779 . The device of claim 4769 wherein the fibrosing agent is or comprises silk.

4780 .- 4783 . (canceled)

4784 . The device of claim 4769 wherein the fibrosing agent is or comprises bleomycin.

4785 .- 4840 . (canceled)

4841 . The device of claim 4769 , further comprising a second pharmaceutically active agent.

4842 . (canceled)

4843 . The device of claim 4769 , further comprising an agent that inhibits infection.

4844 .- 4892 . (canceled)

4893 . A medical device comprising a wire implant and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

4894 . (canceled)

4895 . The device of claim 4893 wherein the fibrosing agent promotes angiogenesis.

4896 . The device of claim 4893 wherein the fibrosing agent promotes fibroblast migration.

4897 . The device of claim 4893 wherein the fibrosing agent promotes fibroblast proliferation.

4898 . The device of claim 4893 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

4899 . The device of claim 4893 wherein the fibrosing agent promotes tissue remodeling.

4900 . The device of claim 4893 wherein the fibrosing agent is an arterial vessel wall irritant.

4901 . (canceled)

4902 . (canceled)

4903 . The device of claim 4893 wherein the fibrosing agent is or comprises silk.

4904 .- 4907 . (canceled)

4908 . The device of claim 4893 wherein the fibrosing agent is or comprises bleomycin.

4909 .- 4964 . (canceled)

4965 . The device of claim 4893 , further comprising a second pharmaceutically active agent.

4966 . (canceled)

4967 . The device of claim 4893 , further comprising an agent that inhibits infection.

4968 .- 5016 . (canceled)

5017 . A medical device comprising a collagen implant and a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

5018 . (canceled)

5019 . The device of claim 5017 wherein the fibrosing agent promotes angiogenesis.

5020 . The device of claim 5017 wherein the fibrosing agent promotes fibroblast migration.

5021 . The device of claim 5017 wherein the fibrosing agent promotes fibroblast proliferation.

5022 . The device of claim 5017 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

5023 . The device of claim 5017 wherein the fibrosing agent promotes tissue remodeling.

5024 . The device of claim 5017 wherein the fibrosing agent is an arterial vessel wall irritant.

5025 . (canceled)

5026 . (canceled)

5027 . The device of claim 5017 wherein the fibrosing agent is or comprises silk.

5028 .- 5031 . (canceled)

5032 . The device of claim 5017 wherein the fibrosing agent is or comprises bleomycin.

5033 .- 5088 . (canceled)

5089 . The device of claim 5017 , further comprising a second pharmaceutically active agent.

5090 . (canceled)

5091 . The device of claim 5017 , further comprising an agent that inhibits infection.

5092 .- 7478 . (canceled)

7479 . A method of making a medical device comprising combining i) an orthopedic implant and ii) a fibrosing agent or a composition comprising a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

7480 . (canceled)

7481 . The method of claim 7479 wherein the fibrosing agent promotes angiogenesis.

7482 . The method of claim 7479 wherein the fibrosing agent promotes fibroblast migration.

7483 . The method of claim 7479 wherein the fibrosing agent promotes fibroblast proliferation.

7484 . The method of claim 7479 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

7485 . The method of claim 7479 wherein the fibrosing agent promotes tissue remodeling.

7486 . The method of claim 7479 wherein the fibrosing agent is an arterial vessel wall irritant.

7487 . (canceled)

7488 . (canceled)

7489 . The method of claim 7479 wherein the fibrosing agent is or comprises silk.

7490 .- 7493 . (canceled)

7494 . The method of claim 7479 wherein the fibrosing agent is or comprises bleomycin.

7495 .- 7548 . (canceled)

7549 . The method of claim 7479 , wherein the implant is further combined with a second pharmaceutically active agent.

7550 . (canceled)

7551 . The method of claim 7479 wherein the implant is further combined with an agent that inhibits infection.

7552 .- 7603 . (canceled)

7604 . A method of making a medical device comprising combining i) an orthopedic prosthesis and ii) a fibrosing agent or a composition comprising a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

7605 . (canceled)

7606 . The method of claim 7604 wherein the fibrosing agent promotes angiogenesis.

7607 . The method of claim 7604 wherein the fibrosing agent promotes fibroblast migration.

7608 . The method of claim 7604 wherein the fibrosing agent promotes fibroblast proliferation.

7609 . The method of claim 7604 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

7610 . The method of claim 7604 wherein the fibrosing agent promotes tissue remodeling.

7611 . The method of claim 7604 wherein the fibrosing agent is an arterial vessel wall irritant.

7612 . (canceled)

7613 . (canceled)

7614 . The method of claim 7604 wherein the fibrosing agent is or comprises silk.

7615 .- 7618 . (canceled)

7619 . The method of claim 7604 wherein the fibrosing agent is or comprises bleomycin.

7620 .- 7673 . (canceled)

7674 . The method of claim 7604 , wherein the prosthesis is further combined with a second pharmaceutically active agent.

7675 . (canceled)

7676 . The method of claim 7604 wherein the prosthesis is further combined with an agent that inhibits infection.

7677 .- 7856 . (canceled)

7857 . A method of making a medical device comprising combining i) an internal fixation implant and ii) a fibrosing agent or a composition comprising a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

7858 . (canceled)

7859 . The method of claim 7857 wherein the fibrosing agent promotes angiogenesis.

7860 . The method of claim 7857 wherein the fibrosing agent promotes fibroblast migration.

7861 . The method of claim 7857 wherein the fibrosing agent promotes fibroblast proliferation.

7862 . The method of claim 7857 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

7863 . The method of claim 7857 wherein the fibrosing agent promotes tissue remodeling.

7864 . The method of claim 7857 wherein the fibrosing agent is an arterial vessel wall irritant.

7865 . (canceled)

7866 . (canceled)

7867 . The method of claim 7857 wherein the fibrosing agent is or comprises silk.

7868 .- 7871 . (canceled)

7872 . The method of claim 7857 wherein the fibrosing agent is or comprises bleomycin.

7873 .- 7926 . (canceled)

7927 . The method of claim 7857 , wherein the implant is further combined with a second pharmaceutically active agent.

7928 . (canceled)

7929 . The method of claim 7857 wherein the implant is further combined with an agent that inhibits infection.

7930 .- 7992 . (canceled)

7993 . A method of making a medical device comprising combining i) an external fixation implant and ii) a fibrosing agent or a composition comprising a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

7994 . (canceled)

7995 . The method of claim 7993 wherein the fibrosing agent promotes angiogenesis.

7996 . The method of claim 7993 wherein the fibrosing agent promotes fibroblast migration.

7997 . The method of claim 7993 wherein the fibrosing agent promotes fibroblast proliferation.

7998 . The method of claim 7993 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

7999 . The method of claim 7993 wherein the fibrosing agent promotes tissue remodeling.

8000 . The method of claim 7993 wherein the fibrosing agent is an arterial vessel wall irritant.

8001 . (canceled)

8002 . (canceled)

8003 . The method of claim 7993 wherein the fibrosing agent is or comprises silk.

8004 .- 8007 . (canceled)

8008 . The method of claim 7993 wherein the fibrosing agent is or comprises bleomycin.

8009 .- 8062 . (canceled)

8063 . The method of claim 7993 , wherein the implant is further combined with a second pharmaceutically active agent.

8064 . (canceled)

8065 . The method of claim 7993 wherein the implant is further combined with an agent that inhibits infection.

8066 .- 8117 . (canceled)

8118 . A method of making a medical device comprising combining i) a collagen implant and ii) a fibrosing agent or a composition comprising a fibrosing agent, where the fibrosing agent induces a fibrotic response between the device and a patient in which the device is implanted.

8119 . (canceled)

8120 . The method of claim 8118 wherein the fibrosing agent promotes angiogenesis.

8121 . The method of claim 8118 wherein the fibrosing agent promotes fibroblast migration.

8122 . The method of claim 8118 wherein the fibrosing agent promotes fibroblast proliferation.

8123 . The method of claim 8118 wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).

8124 . The method of claim 8118 wherein the fibrosing agent promotes tissue remodeling.

8125 . The method of claim 8118 wherein the fibrosing agent is an arterial vessel wall irritant.

8126 . (canceled)

8127 . (canceled)

8128 . The method of claim 8118 wherein the fibrosing agent is or comprises silk.

8129 .- 8132 . (canceled)

8133 . The method of claim 8118 wherein the fibrosing agent is or comprises bleomycin.

8134 .- 8187 . (canceled)

8188 . The method of claim 8118 , wherein the implant is further combined with a second pharmaceutically active agent.

8189 . (canceled)

8190 . The method of claim 8118 wherein the implant is further combined with an agent that inhibits infection.

8191 .- 10247 . (canceled)

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