US2006241025A1PendingUtilityA1

Biodegradable glucosamine-muramyl peptides for apoptosis modulation

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Individually held — no corporate assignee on recordPriority: Apr 9, 2003Filed: Jun 21, 2006Published: Oct 26, 2006
Est. expiryApr 9, 2023(expired)· nominal 20-yr term from priority
Inventors:Vladimir SlesarevTodor Dimitrov
C12P 21/06C07K 9/005A61K 38/00
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Claims

Abstract

The present invention includes apoptosis modulating glucosamine-muramyl-peptides, obtained by specific endopeptidase digestion of gram positive bacteria, methods of preparation of thereof and medical food compositions for management and treatment of conditions caused by TNF alpha cytotoxicity.

Claims

exact text as granted — not AI-modified
1 . A Biodegradable glucosamine-muramyl-peptides of the general formula  
     
       
         
         
             
             
         
       
     
     where R1 is lysine or ornithine residue, R2 is amino acid residue selected from the group of D-alanine, L-alanine, D-aspartic acid, L-glycine, L-serine, D-serine, and L-threonine, and R3 is amino acid residue selected from the L-glycine, D-asparagine, D-aspartic acid, and D-glutamine.  
   
   
       2 . The composition of  claim 1 , wherein the biodegradable compound is  
     
       
         
         
             
             
         
       
     
   
   
       3 . The composition of  claim 1 , wherein the biodegradable compound is  
     
       
         
         
             
             
         
       
     
   
   
       4 . The composition of  claim 1 , wherein the biodegradable compound is  
     
       
         
         
             
             
         
       
     
   
   
       5 . The composition of  claim 1 , wherein the biodegradable compound is  
     
       
         
         
             
             
         
       
     
   
   
       6 . The composition of  claim 1 , wherein the biodegradable compound is

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