Hollow microspheres with controlled fragility for medical use

Abstract

A composition for ultrasonic imaging is described having a microparticle population of controlled fragility. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.

1 . A method of echographic imaging using a microbubble contrast agent in a region of interest within a fluid-filled cavity, vessel, or fluid perfused tissue comprising the steps of: 
 a. introducing a microbubble contrast agent consisting of a microbubble population having a constant wall thickness to diameter ratio that is characterized by a threshold intensity of ultrasonic power of microbubble rupture that is within the power range useful for diagnostic imaging into said region of interest,    b. applying an ultrasonic signal to said region of interest at an applied power intensity greater than said threshold intensity.