Tissue biopsy and treatment apparatus and method

Abstract

A method of treating a tumor includes providing a tissue biopsy and treatment apparatus that includes an elongated delivery device that has a lumen and is maneuverable in tissue. A sensor array having a plurality of resilient members is deployable from the elongated delivery device. At least one of the plurality of resilient members is positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state. At least one of the plurality of resilient members includes at least one of a sensor, a tissue piercing distal end or a lumen. The sensor array has a geometric configuration adapted to volumetrically sample tissue at a tissue site to differentiate or identify tissue at the tissue site. At least one energy delivery device is coupled to one of the sensor array, at least one of the plurality of resilient members or the elongated delivery device. The apparatus is then introduced into a target tissue site. The sensor array is then utilized to distinguish a tissue type. The tissue type information derived from the sensor array is utilized to position the energy delivery device to ablate a tumor volume. Energy is then delivered from the energy delivery device to ablate or necrose at least a portion of the tumor volume. The sensor array is then utilized to determine an amount of tumor volume ablation.

1 . A method of treating a tumor comprising: 
 positioning a tissue biopsy and treatment apparatus for detecting and treating a tumor at a selected tissue site,    deploying a sensor array from the appratus, the sensor array including at least one emitting member and at least one detecting member;    deploying a plurality of resilient members from the elongated delivery device, at least one of the plurality of resilient members being positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state, at least one of the plurality of resilient members including at least one sensor,    distinguishing a tissue type utilizing the sensor array to measure a spectral profile of at least one portion of the tissue site to determine a tumor volume;    delivering energy to said resilient members to ablate or necrose at least a portion of the tumor volume; and    determining an amount of tumor volume ablation utilizing the sensor array.    
     
     
         2 - 104 . (canceled)  
     
     
         105 . A tissue biopsy and treatment apparatus for detecting and treating tumors, the apparatus comprising: 
 an elongated delivery device including a lumen, the elongated delivery device being maneuverable in tissue;    at least one sensor array configured to measure a spectral profile of at least a portion of a tissue site, the array comprising at least one emitting member and at least one detecting member;    a plurality of resilient members each having a tissue piercing distal portion, at least one of the plurality of resilient members being positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state, said resilient members being operatively connected to a source of energy for ablating tissue when energy is supplied to the resilient members.    
     
     
         106 . The apparatus of  claim 105 , further comprising: 
 an optical switching device coupled to the sensor array to switch a mode of at least one of the emitting members or the detecting members.    
     
     
         107 . The apparatus of  claim 105 , wherein the sensor array is deployable from the elongated delivery device.  
     
     
         108 . The apparatus of  claim 105 , wherein at least one of the sensor arrays is positioned in one of the resilient members.  
     
     
         109 . The apparatus of  claim 108 , wherein the sensor array is fixedly positioned in the resilient member.  
     
     
         110 . The apparatus of  claim 108 , wherein the sensor array is deployable from the resilient member.  
     
     
         111 . The apparatus of  claim 105 , further comprising: 
 an optical measurement device operatively connected to the at least one sensor array.    
     
     
         112 . The apparatus of  claim 105 , further comprising: 
 a light source operatively connected to the at least one sensor array.    
     
     
         113 . The apparatus of  claim 105 , further comprising: 
 at least one advancement device operatively connected to at least one of the sensor array and the plurality of resilient members.    
     
     
         114 . The apparatus of  claim 105 , further comprising: 
 at least one thermal sensor positioned on at least one of (i) the sensor array, (ii) the plurality of resilient members, and (iii) the elongated delivery device.