Carboxylic derivates

Abstract

The present invention provides a compound of formula I processes for preparing such compounds, their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeutic use and pharmaceutical compositions containing them.

1 - 18 . (canceled)  
     
     
         19 . A compound of formula I  
       
         
           
           
               
               
           
         
       
       as well as optical isomers and racemates therof as well as pharmaceutically acceptable salts, prodrugs, solvates and crystalline forms thereof,  
       wherein 
 A is situated in the para position and represents  
                     
 R is —OR a , wherein R a  represents hydrogen;  
 R 1  is —OR e , wherein R e  is alkyl  
 R 2  is hydrogen;  
 R 3  and R 4  are hydrogen,;  
 T represents O;  
 n represents 1;  
 R 5  is hydrogen;  
 R 6  independently represent hydrogen, C 1-13 alkyl, C 2-10 alkenyl or C 2-10 alkynyl each of which is optionally substituted by one or more of the following which may be the same or different: C 3-8 cycloalkyl, C 3-8 cycloalkenyl, aryl, heterocyclyl, heteroaryl, C 1-8 alkoxy (optionally substituted by one or more fluoro), C 3-8 cycloalkoxy, C 3-8 cycloalkenyloxy, aryloxy, heterocyclyloxy, heteroaryloxy, C 3-8 cycloalkyl C 1-8 alkoxy, aryl C 1-8 alkoxy, heterocyclyl C 1-8  alkoxy or heteroaryl C 1-8  alkoxy, fluorine or hydroxy and wherein each of these substituents may optionally be substituted on carbon with one or more substituents which may be the same or different and selected from C 1-8 alkyl, C 3-8 cycloalkyl (optionally substituted by C 1-8 alkyl, C 1-8 alkoxy (optionally substituted by one or more fluoro), halogen, hydroxy, nitro or cyano), aryl (optionally substituted by C 1-8 alkyl, C 1-8 alkoxy (optionally substituted by one or more fluoro), halogen, hydroxy, nitro or cyano), heterocyclyl (optionally substituted by C 1-6 alkyl on any nitrogen), heteroaryl (optionally substituted by C 1-8 alkyl, C 1-8 alkoxy (optionally substituted by one or more fluoro), halogen, hydroxy, nitro or cyano), C 1-8 alkoxy (optionally substituted by one or more fluoro), C 3-8 cycloalkoxy, C 3-8  cycloalkyl C 1-8 alkoxy, aryloxy (optionally substituted by C 1-8 alkyl, C 1-8 alkoxy (optionally substituted by one or more fluoro), halogen, hydroxy, nitro or cyano), aryl C 1-8 alkoxy (wherein the aryl part is optionally substituted by C 1-8 alkyl, C 1-8 alkoxy (optionally substituted by one or more fluoro), halogen, hydroxy, nitro or cyano), halogen, amino, nitro, hydroxy, methylsulfonyl, methylsulfonyloxy, cyano or methylenedioxy,  
 or R 5  and R 6  independently represent C 3 -C 8  cycloalkyl; C 3 -C 8  cycloalkenyl; aryl; heterocyclyl; or heteroaryl; wherein each of these groups is optionally substituted by one or more of the following: C 1-8 alkyl, C 1-8 alkoxy (optionally substituted by one or more fluoro), halogen, hydroxy, nitro or cyano), aryl (optionally substituted by C 1-8 alkyl, C 1-8 alkoxy (optionally substituted by one or more fluoro), halogen, hydroxy, nitro or cyano;  
 or R 5  and R 6  together with the nitrogen atom to which they are attached form a single or a fused heterocyclic system.  
 
     
     
         20 . A compound according to  claim 19;   wherein, R 6  represents; C 1-3 alkyl, which is optionally substituted by aryl, and wherein the aryl is optionally substituted on carbon with C 1-8 alkoxy.    
     
     
         21 . A compound according to  claim 20 , 
 wherein, R 6  represents C 1-13  alkyl, substituted by aryl, which in its turn is substituted on carbon with C 1-8  alkoxy.    
     
     
         22 . A compound according to  claim 19 , wherein R 5  is H.  
     
     
         23 . A compound according to  claim 19 , wherein R 5  is H; and 
 R 6  represents; C 1-13 alkyl, which is optionally substituted by aryl, and wherein the aryl is optionally substituted on carbon with C 1-8 alkoxy.    
     
     
         24 . A compound according to  claim 19 , wherein R 5  is H; and 
 R 6  represents C 1-13  alkyl, substituted by aryl, which in its turn is substituted on carbon with C 1-8  alkoxy.