Methods and systems for enabling and stabilizing tooth movement

Abstract

Orthodontic methods comprise applying force to reposition teeth and administering a tissue remodeling and/or an angiogenic substance(s) to the periodontal tissue surrounding the teeth to be moved. The substance(s) may be delivered before, during, or after the teeth are moved, and the substance(s) may be selectively applied only to those teeth undergoing movement at any particular time. The substance(s) may be applied from the dental repositioning appliance or may be applied separately, either topically or by injection.

1 . A method for enhancing tooth mobility or stability, said method comprising administering a tissue remodeling and/or angiogenic substance(s) to a living host.  
   
   
       2 . A method as in  claim 1 , wherein the host will be having, is having, or has had orthodontic treatment.  
   
   
       3 . A method as in  claim 1 , wherein the substance(s) comprises relaxin or an analog or mimetic thereof.  
   
   
       4 . A method as in  claim 1 , wherein the substance(s) comprises an angiogenic substance(s) selected from the group consisting of VEGF, bFGF, estrogen, nitrous oxide and naltrexone.