US2006269976A1PendingUtilityA1

Method for reducing lysozyme enzymatic activity

49
Assignee: BIOKIT SAPriority: Dec 23, 2003Filed: Apr 5, 2006Published: Nov 30, 2006
Est. expiryDec 23, 2023(expired)· nominal 20-yr term from priority
Inventors:Francois-Xavier BerthetFrancesc Vayreda CasadevallMaria Cruz Sanz MariaTeresa Llop GarciaAngels Mor Olle
A61P 37/08A61P 43/00A61P 37/04A61P 35/02A61P 31/22A61P 35/00A61P 31/06A61P 27/16A61P 31/18A61P 31/20A61P 33/06A61P 29/00A61P 31/16A61P 25/28A61P 31/14A61P 31/00A61P 31/04A61P 11/16A61P 15/18G01N 33/56983A61P 15/16A61P 1/04G01N 33/571G01N 2800/347G01N 2500/02G01N 2800/24G01N 2333/20A61P 15/02A61K 38/164G01N 33/56911G01N 2333/924G01N 2469/20G01N 2800/2821C12N 9/2462C07K 14/20A61P 1/02G01N 33/573G01N 2800/065A61P 11/00A61P 13/12Y02A50/30
49
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Claims

Abstract

The present invention generally features therapeutic and diagnostic compositions and methods for increasing or decreasing the binding of a lysozyme polypeptide to a Treponema pallidum P17 polypeptide (Tp17) or a Tp17-like polypeptide. More particularly, the invention relates to compositions and methods for detecting, treating, or preventing a pathogen infection or a chronic disorder; and to binding assays using a Tp17-like polypeptide and a lysozyme polypeptide.

Claims

exact text as granted — not AI-modified
1 - 66 . (canceled)  
     
     
         67 . A method for reducing lysozyme enzymatic activity in a sample, the method comprising contacting a sample with a Tp17-like polypeptide under conditions that permit binding of the polypeptide to the lysozyme, wherein the Tp17-like polypeptide does not comprise an Ivy protein.  
     
     
         68 . A method for reducing lysozyme enzymatic activity in a subject the method comprising administering to the subject an effective amount of a Tp17-like polypeptide or fragment thereof.  
     
     
         69 . The method of  claim 67 , wherein the polypeptide is  Treponema pallidum  P17 polypeptide.  
     
     
         70 . The method of  claim 67 , wherein the method is used to treat or prevent a disease selected from the group consisting of cancer, Alzheimer's disease, renal amyloidosis, leukemia, Crohn's disease, and allergy.  
     
     
         71 - 80 . (canceled)  
     
     
         81 . The method of  claim 68 , wherein the polypeptide is  Treponema pallidum  P17 polypeptide.  
     
     
         82 . The method of  claim 68 , wherein the method is used to treat or prevent a disease selected from the group consisting of cancer, Alzheimer's disease, renal amyloidosis, leukemia, Crohn's disease, and allergy.

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