US2006270835A1PendingUtilityA1

Diagnosis and treatment of Alzheimer disease

48
Assignee: BIOKIT SAPriority: Dec 23, 2003Filed: Apr 6, 2006Published: Nov 30, 2006
Est. expiryDec 23, 2023(expired)· nominal 20-yr term from priority
Inventors:Francois-Xavier BerthetFrancesc Vayreda CasadevallMaria Cruz Sanz MariaTeresa GarciaAngels Olle
A61P 37/08A61P 43/00A61P 37/04A61P 31/16A61P 31/22A61P 31/14A61P 33/06A61P 31/04A61P 35/00A61P 27/16A61P 31/20A61P 25/28A61P 31/00A61P 31/06A61P 29/00A61P 35/02A61P 31/18A61K 38/164G01N 2500/02G01N 2333/924G01N 2800/347G01N 33/573G01N 2800/24C07K 14/20G01N 2800/065C12N 9/2462A61P 11/00A61P 15/16G01N 33/56983G01N 33/56911G01N 2800/2821A61P 13/12A61P 1/02G01N 2469/20G01N 2333/20G01N 33/571A61P 15/18A61P 15/02A61P 1/04A61P 11/16Y02A50/30
48
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Claims

Abstract

The present invention generally features therapeutic and diagnostic compositions and methods for increasing or decreasing the binding of a lysozyme polypeptide to a Treponema pallidum P17 polypeptide (Tp17) or a Tp17-like polypeptide. More particularly, the invention relates to compositions and methods for detecting, treating, or preventing a pathogen infection or a chronic disorder; and to binding assays using a Tp17-like polypeptide and a lysozyme polypeptide.

Claims

exact text as granted — not AI-modified
1 - 70 . (canceled)  
     
     
         71 . A composition comprising an APP-like polypeptide and a substantially pure lysozyme polypeptide.  
     
     
         72 . A method of diagnosing Alzheimer's disease in a subject, the method comprising detecting the presence in a sample from the subject of a complex between an APP-like polypeptide and a lysozyme polypeptide, or the presence of an antibody that binds to such a complex.  
     
     
         73 . A method for identifying a candidate compound that modulates binding between the APP-like polypeptide and a lysozyme polypeptide, the method comprising detecting a reduction in binding between the Tp17-like polypeptide and the lysozyme polypeptide in the presence of the candidate compound.  
     
     
         74 .  74 - 80  (canceled)

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