Polymer complexes of glucuronoglucanes

Abstract

A biocompatible intermolecular polymer complex comprises an anionic component and a non protein cationic component. The anionic component comprises a linear or branched polysaccharide chain wherein at least 5% of the basic structural units are glucuronic acid. The cationic component comprises a linear or branched natural, semi-synthetic or synthetic oligomer or polymer.

1 - 33 . (canceled)  
   
   
       34 . A pharmaceutical or cosmetic composition including at least one biocompatible intermolecular polymer complex of: 
 an anionic component comprising a linear or branched polysaccharide chain wherein at least 5% of the basic structural units are glucuronic acid; and    a non protein cationic component comprising a linear or branched natural, semi-synthetic or synthetic oligomer or polymer.    
   
   
       35 . The composition as claimed in  claim 34  wherein the cationic component contains nitrogen that either carries a positive charge or wherein the positive charge is induced by contact with the polysaccharidic anionic component.  
   
   
       36 . The composition as claimed in  claim 35  wherein the cationic component is selected from derivatives of acrylamide, methacrylamide and copolymers thereof.  
   
   
       37 . The composition as claimed in  claim 34  wherein the cationic component is a cationised natural polysaccharide.  
   
   
       38 . The composition as claimed in  claim 37  wherein the polysaccharide is a starch, cellulose or gum.  
   
   
       39 . The composition as claimed in  claim 34  wherein the cationic component is a synthetic or semi-synthetic polyamino acid.  
   
   
       40 . The composition as claimed in  claim 34  wherein the cationic component is a synthetic anti-fibrinolytic.  
   
   
       41 . The composition as claimed in  claim 34  wherein the cationic component is a natural or semi-synthetic peptide.  
   
   
       42 . The composition as claimed in  claim 34  wherein the cationic component is an aminoglucane or derivatives thereof.  
   
   
       43 . The composition as claimed in  claim 34  wherein the anionic component is polyanhydroglucuronic acid.  
   
   
       44 . The composition as claimed in  claim 43  wherein the polyanhydroglucuronic acid and salts thereof contain in their polymeric chain from 8 to 30 per cent by weight of carboxyl groups, at least 80 per cent by weight of these groups being of the uronic group, at most 5 per cent by weight of carbonyl groups, and at most 0.5 per cent by weight of bound nitrogen.  
   
   
       45 . The composition as claimed in  claim 44  wherein the polyanhydroglucuronic acid and salts thereof contain in their polymeric chain at most 0.2 per cent by weight of bound nitrogen.  
   
   
       46 . The composition as claimed in  claim 44  wherein the molecular mass of the polymeric chain of the anionic component is from 1×10 3  to 3×10 5  Daltons.  
   
   
       47 . The composition as claimed in  claim 44  wherein the content of carboxyl groups is in the range of from 12 to 26 per cent by weight, at least 95 per cent of these groups being of the uronic group.  
   
   
       48 . The composition as claimed in  claim 44  wherein the anionic component contains at most 1 per cent by weight of carbonyl groups.  
   
   
       49 . The composition as claimed in  claim 44  wherein the carbonyl groups are intra- and intermolecular 2,6 and 3,6 hemiacetals, 2,4-hemialdals and C2-C3 aldehydes.  
   
   
       50 . The composition as claimed in  claim 34  wherein the cationic component is gelatine.  
   
   
       51 . The composition as claimed in  claim 34  wherein the cationic component is chitosan.  
   
   
       52 . The composition as claimed in  claim 34  including at least one biocompatible biologically active substance.  
   
   
       53 . The composition as claimed in  claim 34  including at least one biologically acceptable adjuvant.  
   
   
       54 . The composition as claimed in  claim 34  wherein the composition is a slow release formulation.  
   
   
       55 . The composition as claimed in  claim 34  wherein the composition is a suppository formulation.  
   
   
       56 . The composition as claimed in  claim 34  wherein the composition is in the form of a tablet.  
   
   
       57 . The composition as claimed in  claim 34  wherein the composition is in the form of a pellet.  
   
   
       58 . The composition as claimed in  claim 34  wherein the composition is in the form of a granule.  
   
   
       59 . The composition as claimed in  claim 34  wherein the composition is in the form of a microsphere.  
   
   
       60 . The composition as claimed in  claim 34  wherein the composition is in the form of a flat flexible material.  
   
   
       61 . The composition as claimed in  claim 35  wherein the cationic component is selected from polyacrylamide, copolymer of hydroxyethylmethacrylate and hydroxypropylmethacrylamide, copolymers of acrylamide, butylacrylate, maleinanhydride and/or methylmetacrylate.  
   
   
       62 . The composition as claimed in  claim 38  wherein the gum is guargumhydroxypropyl-triammonium chloride.  
   
   
       63 . The composition as claimed in  claim 34  wherein the cationic component is polylysin, polyarginin, or α,β-poly-(N-(2-hydroxyethyl)-DL-aspartamide).  
   
   
       64 . The composition as claimed in  claim 40  wherein the anti-fibrinolytic is a hexadimethrindibromide (polybren).  
   
   
       65 . The composition as claimed in  claim 41  wherein the peptide is a protamine, gelatine, fibrinopeptide, or derivatives thereof.  
   
   
       66 . The composition as claimed in  claim 42  wherein the aminoglucane is fractionated chitin or its de-acetylated derivative chitosan.  
   
   
       67 . The composition as claimed in  claim 42  wherein the aminoglucane is of microbial origin or is isolated from the shells of arthropods.  
   
   
       68 . The composition as claimed in  claim 44  wherein the molecular mass of the polymeric chain of the anionic component ranges from 5×10 3  to 1.5×10 5  Daltons.  
   
   
       69 . A textile-like fabric comprising at least one biocompatible intermolecular polymer complex of: 
 an anionic component comprising a linear or branched polysaccharide chain wherein at least 5% of the basic structural units are glucuronic acid; and    a non protein cationic component comprising a linear or branched natural, semi-synthetic or synthetic oligomer or polymer.    
   
   
       70 . A foam comprising at least one biocompatible intermolecular polymer complex of: 
 an anionic component comprising a linear or branched polysaccharide chain wherein at least 5% of the basic structural units are glucuronic acid; and    a non protein cationic component comprising a linear or branched natural, semi-synthetic or synthetic oligomer or polymer.    
   
   
       71 . A dental pin comprising at least one biocompatible intermolecular polymer complex of: 
 an anionic component comprising a linear or branched polysaccharide chain wherein at least 5% of the basic structural units are glucuronic acid; and    a non protein cationic component comprising a linear or branched natural, semi-synthetic or synthetic oligomer or polymer.