Mutations in OAS1 genes

Abstract

Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided.

1 . (canceled)  
     
     
         2 . An oligoadenylate synthetase 1 protein comprising a polypeptide having the amino acid sequence of SEQ ID NO:1 except for at least one amino acid modification at position 1, 24, 25, 28, 31, 36, 47, 53, 54, 64, 69, 74, 104, 108, 112, 113, 114, 115, 116, 117, 118, 119, 127, 130, 139, 142, 160, 161, 162, 166, 175, 179, 226, 242, 246, 248, 250, 254, 274, 279, 282, 284, 288, 289, 292, 295, 314, 315, and 335.  
     
     
         3 - 5 . (canceled)  
     
     
         6 . An oligoadenylate synthetase 1 protein comprising a polypeptide having the amino acid sequence of SEQ ID NO:2 except for at least one amino acid modification at position 1, 24, 25, 28, 31, 36, 47, 53, 54, 64, 69, 74, 104, 108, 112, 113, 114, 115, 116, 117, 118, 119, 127, 130, 139, 142, 160, 161, 162, 166, 175, 179, 226, 242, 246, 248, 250, 254, 274, 279, 282, 284, 288, 289, 292, 295, 314, 315, 335, 347, 350, 352, 353, 354, 356, 357, 361, 363, 364, 365, 369, 371, 373, 374, 375, 378, 379, 382, 388, 389, and 394.  
     
     
         7 . An oligoadenylate synthetase 1 protein comprising a polypeptide having the amino acid sequence of SEQ ID NO:3 except for at least one amino acid modification at position 1, 24, 25, 28, 31, 36, 47, 53, 54, 64, 69, 74, 104, 108, 112, 113, 114, 115, 116, 117, 118, 119, 127, 130, 139, 142, 160, 161, 162, 166, 175, 179, 226, 242, 246, 248, 250, 254, 274, 279, 282, 284, 288, 289, 292, 295, 314, 315, 335, and 363.  
     
     
         8 . An oligoadenylate synthetase 1 protein comprising a polypeptide having the amino acid sequence of SEQ ID NO:4 except for at least one amino acid modification at position 1, 24, 25, 28, 31, 36, 47, 53, 54, 64, 69, 74, 104, 108, 112, 113, 114, 115, 116, 117, 118, 119, 127, 130, 139, 142, 160, 161, 162, 166, 175, 179, 226, 242, 246, 248, 250, 254, 274, 279, 282, 284, 288, 289, 292, 295, 314, 315, 335, 347, 361, 364, 372, 384, 385, and 399.  
     
     
         9 . An oligoadenylate synthetase 1 protein comprising a polypeptide having the amino acid sequence of any one of SEQ ID NO:5-16.  
     
     
         10 . (canceled)  
     
     
         11 . A therapeutic composition for treating or preventing infection by a virus in a mammal wherein said composition is the polypeptide of any one of claims  2 ,  6 ,  7 ,  8  or  9  together with a pharmaceutically acceptable carrier.  
     
     
         12 . (canceled)  
     
     
         13 . The therapeutic composition of  claim 11  wherein the virus is hepatitis C virus.  
     
     
         14 - 23 . (canceled)  
     
     
         24 . A method for treating a viral disease in a mammalian subject which comprises providing to a subject in need of such treatment a therapeutic composition of  claim 11 .  
     
     
         25 - 28 . (canceled)