Lipid-regulating agent and use thereof

Abstract

The object of the present invention is to provide a lipid-regulating agent or a composition for regulating the amount of lipids comprising the agent. The present invention solves the above object by providing a lipid-regulating agent comprising a cyclic tetrasaccharide and/or its saccharide-derivative(s) and a composition for regulating the amount of lipids comprising the lipid-regulating agent.

1 . A lipid-regulating agent, which comprises a cyclic tetrasaccharide, represented by the formula of cyclo {{cube root}6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→}, and/or its saccharide-derivative(s) as an effective ingredient(s)  
     
     
         2 . The lipid-regulating agent of  claim 1 , where one or more substances selected from the group consisting of a non-reducing saccharide, reducing saccharide, cyclodextrin, water-soluble polysaccharide, polyphenol, spice, acidifier, seasoning, alcohol, organic acid, organic acid salt, inorganic salt, emulsifier, flavor, and coloring are incorporated into said cyclic tetrasaccharide, represented by the formula of cyclo {→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-( →}, and/or said saccharide-derivative(s)    
     
     
         3 . The lipid-regulating agent of  claim 2 , wherein said non-reducing saccharide is one or more saccharides selected from the group consisting of maltitol, α,α-trehalose, and a saccharide-derivative of α,α-trehalose.  
     
     
         4 . The lipid-regulating agent of  claim 2 , wherein said polyphenol is one or more substances selected from the group consisting of flavonoids such as hesperetin, naringenin, querucetin, hesperidin, enzymatically-modified hesperidin, naringin, enzymatically-modified naringin, rutin, enzymatically-modified rutin, and proanthocyanidin; and catechins such as catechin and epigallocatechin.  
     
     
         5 . The lipid-regulating agent of  claim 1 , which comprises said cyclic tetrasaccharide, represented by the formula of cyclo {→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→}, and/or said saccharide-derivative(s) in a total amount of 0.1% (w/w) or higher, on a dry solid basis.  
     
     
         6 . A composition for regulating the amount of lipids, which comprises the lipid-regulating agent of  claim 1 .  
     
     
         7 . The composition for regulating the amount of lipids of  claim 6 , which comprises a cyclic tetrasaccharide, represented by the formula of cyclo {→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→}, and/or said saccharide-derivative(s) in a total amount of 0.01% (w/w) or higher, on a dry solid basis.  
     
     
         8 . The lipid-regulating agent  claim 1 , where lipid-regulating means the regulation the amount of lipids in said living body.  
     
     
         9 . The lipid-regulating agent of  claim 8 , wherein said lipid in said living body is one or more lipids selected from the group consisting of free fatty acids, simple lipids (homolipids), compound lipids (heterolipids), lipoproteins, and free cholesterols.  
     
     
         10 . The lipid-regulating agent of  claim 8 , wherein said lipids in said living body exist in one or more tissues or organs selected from the group consisting of blood, subcutaneous tissue, intracutaneous tissue, testis, kidney, heart, liver, and digestive tract.  
     
     
         11 . The lipid-regulating agent of  claim 9 , wherein said simple lipids (homolipids) are triglycerides.  
     
     
         12 . The lipid-regulating agent of  claim 1 , which is used for improving a lifestyle-related disease.  
     
     
         13 . The lipid-regulating agent of  claim 12 , wherein said lifestyle-related disease is one or more diseases selected from the group consisting of hyperlipemia, arteriosclerosis, angiostenosis, vascular blockage, hypertension, thrombosis, angina, cardiac infarction, cardiac incompetence, brain infarction, fatty incompetence, brain infarction, fatty liver, cirrhosis, adiposis, constipation, colon cancer, and diabetes.  
     
     
         14 . The lipid-regulating agent of  claim 1 , which is used for one or more objects of inhibiting the increase of weight, decreasing total cholesterol, decreasing LDL-cholesterol, regulating the metabolism of lipoproteins, inhibiting the accumulation of lipids, regulating the metabolism of bile acids, and improving the intestinal function.  
     
     
         15 . The lipid-regulating agent of  claim 1 , which is in the form of a pharmaceutical, medicated cosmetic, healthy food, food and beverage, feed, or bait.  
     
     
         16 . The lipid-regulating agent of  claim 1 , which is used for the substitution of lipids.