Modulators of tissue regeneration

Abstract

Proteins which are upregulated in injured or regenerating tissues, as well as the DNA encoding these proteins, are disclosed, as well as therapeutic compositions and methods of treatment encompassing these compounds.

1 - 20 . (canceled)  
     
     
         21 . An antibody or antigen-binding fragment thereof that (i) binds specifically to the extracellular domain of a polypeptide whose amino acid sequence consists of SEQ ID NO:7, and (ii) is conjugated or fused to a toxin or radionuclide.  
     
     
         22 - 36 . (canceled)  
     
     
         37 . The antibody or antigen-binding fragment thereof of  claim 21 , wherein the antibody is a humanized antibody.  
     
     
         38 . The antibody or antigen-binding fragment thereof of  claim 21 , wherein the antibody is a human antibody.  
     
     
         39 . The antibody or antigen-binding fragment thereof of  claim 21 , wherein the antibody is a monoclonal antibody.  
     
     
         40 . The antibody or antigen-binding fragment thereof of  claim 21 , wherein the antibody is a single chain antibody.  
     
     
         41 . The antibody or antigen-binding fragment thereof of  claim 21 , wherein the antibody or antigen-binding fragment thereof is a chimeric antibody, an F ab  fragment, an F (ab′)2  fragment, an F ab′  fragment, or an F v  fragment.  
     
     
         42 . A method of targeting a toxin or radionuclide to a KIM-1 expressing tumor cell, the method comprising contacting a KIM-1 expressing tumor cell with the antibody or antigen-binding fragment thereof of  claim 21 .  
     
     
         43 . The method of  claim 42 , wherein the tumor cell is disposed in vivo in a subject and the antibody or antigen-binding fragment thereof is administered to the subject.  
     
     
         44 . The method of  claim 43 , wherein the tumor cell is a renal tumor cell.  
     
     
         45 . A method of targeting a toxin or radionuclide to a KIM-1 expressing tumor cell, the method comprising contacting a KIM-1 expressing tumor cell with the antibody or antigen-binding fragment thereof of  claim 37 .  
     
     
         46 . The method of  claim 45 , wherein the tumor cell is disposed in vivo in a subject and the antibody or antigen-binding fragment thereof is administered to the subject.  
     
     
         47 . The method of  claim 46 , wherein the tumor cell is a renal tumor cell.  
     
     
         48 . A method of targeting a toxin or radionuclide to a KIM-1 expressing tumor cell, the method comprising contacting a KIM-1 expressing tumor cell with the antibody or antigen-binding fragment thereof of  claim 38 .  
     
     
         49 . The method of  claim 48 , wherein the tumor cell is disposed in vivo in a subject and the antibody or antigen-binding fragment thereof is administered to the subject.  
     
     
         50 . The method of  claim 49 , wherein the tumor cell is a renal tumor cell.  
     
     
         51 . A method of targeting a toxin or radionuclide to a KIM-1 expressing tumor cell, the method comprising contacting a KIM-1 expressing tumor cell with the antibody or antigen-binding fragment thereof of  claim 39 .  
     
     
         52 . The method of  claim 51 , wherein the tumor cell is disposed in vivo in a subject and the antibody or antigen-binding fragment thereof is administered to the subject.  
     
     
         53 . The method of  claim 52 , wherein the tumor cell is a renal tumor cell.  
     
     
         54 . A method of targeting a toxin or radionuclide to a KIM-1 expressing tumor cell, the method comprising contacting a KIM-1 expressing tumor cell with the antibody or antigen-binding fragment thereof of  claim 40 .  
     
     
         55 . The method of  claim 54 , wherein the tumor cell is disposed in vivo in a subject and the antibody or antigen-binding fragment thereof is administered to the subject.  
     
     
         56 . The method of  claim 55 , wherein the tumor cell is a renal tumor cell.  
     
     
         57 . A method of targeting a toxin or radionuclide to a KIM-1 expressing tumor cell, the method comprising contacting a KIM-1 expressing tumor cell with the antibody or antigen-binding fragment thereof of  claim 41 .  
     
     
         58 . The method of  claim 57 , wherein the tumor cell is disposed in vivo in a subject and the antibody or antigen-binding fragment thereof is administered to the subject.  
     
     
         59 . The method of  claim 58 , wherein the tumor cell is a renal tumor cell.