US2006286082A1PendingUtilityA1

Systems and methods for generating biological material

54
Individually held — no corporate assignee on recordPriority: Jun 20, 2005Filed: Jun 14, 2006Published: Dec 21, 2006
Est. expiryJun 20, 2025(expired)· nominal 20-yr term from priority
Inventors:Raymond C. Kurzweil
C07K 1/045G16B 50/00C07K 1/00G16B 25/20C12P 19/34C12N 13/00A61K 35/12G16B 50/30B01J 19/0046C40B 60/14
54
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Claims

Abstract

The invention relates to systems and methods for synthesizing biological material.

Claims

exact text as granted — not AI-modified
1 . A system comprising: 
 a computer configured to execute instructions for synthesizing biological material, and    an assembly unit electrically connected to the computer, the assembly unit being configured to synthesize the biological material based on the instructions executed by the computer.    
   
   
       2 . The system of  claim 1 , further comprising an insertion unit.  
   
   
       3 . The system of  claim 1 , further comprising a repository unit.  
   
   
       4 . The system of  claim 1 , wherein the assembly unit further comprises one or more of an input channel and an output channel.  
   
   
       5 . The system of  claim 1 , further comprising a separate device for a user to communicate wirelessly with the computer.  
   
   
       6 . The system of  claim 1 , wherein the computer comprises one or more of a memory unit, software, and a database.  
   
   
       7 . The system of  claim 6 , wherein the database comprises one or more of DNA sequence, RNA sequence and polypeptide sequence information.  
   
   
       8 . The system of  claim 3 , wherein the repository unit comprises one or more different types of monomeric biological components.  
   
   
       9 . The system of  claim 8 , wherein the monomeric biological components include one or more of a nucleotide, amino acid, and tRNA.  
   
   
       10 . The system of  claim 9 , wherein each tRNA is attached to an amino acid.  
   
   
       11 . The system of  claim 1 , wherein the assembly unit comprises one or more of a polymerase or a ribosome.  
   
   
       12 . The system of  claim 1 , wherein the assembly unit comprises a robot that mimics the activity of a polymerase or a ribosome.  
   
   
       13 . The system of  claim 1 , wherein the biological material is a nucleic acid or polypeptide.  
   
   
       14 . The system of  claim 1 , wherein the biological material is an RNA.  
   
   
       15 . The system of  claim 2 , wherein the insertion unit is attached to the assembly unit.  
   
   
       16 . The system of  claim 1 , wherein the system is coated with a biocompatible material.  
   
   
       17 . A system comprising: 
 a computer configured to execute instructions for synthesizing biological material;    a central unit responsive to execution of the instructions to control an assembly unit; and    an assembly unit electrically connected to the central unit, the assembly unit being configured to synthesize the biological material based on the instructions executed by the computer.    
   
   
       18 . The system of  claim 17 , further comprising a repository unit.  
   
   
       19 . The system of  claim 17 , wherein the assembly unit further comprises one or more of an input channel and an output channel.  
   
   
       20 . The system of  claim 17 , wherein the computer is separate from the central unit and the assembly unit.  
   
   
       21 . The system of  claim 17 , wherein the computer resides outside of the cell and the central unit and the assembly unit reside inside the cell.  
   
   
       22 . The system of  claim 17 , wherein the computer resides within the central unit, and the central unit and the assembly unit reside inside the cell.  
   
   
       23 . The system of  claim 17 , further comprising a separate device for a user to communicate wirelessly with the computer.  
   
   
       24 . The system of  claim 17 , wherein the computer comprises one or more of a transmitter, software, and a database.  
   
   
       25 . The system of  claim 17 , wherein the central unit comprises one or more of a memory, a receiver, an engine, and an antenna.  
   
   
       26 . The system of  claim 24 , wherein the database comprises one or more of DNA sequence, RNA sequence and polypeptide sequence information.  
   
   
       27 . The system of  claim 17 , wherein the system further comprises a repository unit, and the repository unit comprises one or more different types of monomeric biological components.  
   
   
       28 . The system of  claim 27 , wherein the monomeric biological components include one or more of a nucleotide, amino acid, and tRNA.  
   
   
       29 . The system of  claim 28 , wherein each tRNA is attached to an amino acid.  
   
   
       30 . The system of  claim 17 , wherein the assembly unit comprises one or more of a polymerase or a ribosome.  
   
   
       31 . The system of  claim 17 , wherein the assembly unit comprises a robot that mimics the activity of a polymerase or a ribosome.  
   
   
       32 . The system of  claim 17 , wherein the biological material is a nucleic acid or polypeptide.  
   
   
       33 . The system of  claim 17 , wherein the biological material is an RNA.  
   
   
       34 . The system of  claim 17 , wherein the system is coated with a biocompatible material.  
   
   
       35 . A method comprising: 
 synthesizing a biological material and introducing the biological material into a cell,    wherein the biological material is synthesized by a system comprising:    a computer configured to execute instructions for synthesizing biological material, and    an assembly unit electrically connected to the computer, the assembly unit being configured to synthesize the biological material based on the instructions executed by the computer.    
   
   
       36 . The method of  claim 35 , wherein the system further comprises an insertion unit and a repository unit.  
   
   
       37 . The method of  claim 35 , wherein the system further comprises one or more of an input channel and an output channel on the assembly unit.  
   
   
       38 . The method of  claim 35 , wherein the step of synthesizing the biological material is initiated by a signal from a user operating a device separated from the system, wherein the user uses the device to send a signal to a receiver located in the computer of the system.  
   
   
       39 . A method comprising: 
 synthesizing a biological material and introducing the biological material into a cell,    wherein the biological material is synthesized by a system comprising:    a computer configured to execute instructions for synthesizing biological material;    a central unit responsive to execution of the instructions to control an assembly unit; and    an assembly unit electrically connected to the computer, the assembly unit being configured to synthesize the biological material based on the instructions executed by the computer.    
   
   
       40 . The method of  claim 39 , further comprising a repository unit.  
   
   
       41 . The method of  claim 39 , further comprising a step, prior to the synthesizing step, of putting at least the central unit and the assembly unit of the system inside the cell.  
   
   
       42 . The method of  claim 39 , wherein the system further comprises one or more of an input channel and an output channel on the assembly unit.  
   
   
       43 . The method of  claim 41 , wherein the step of putting the central unit and the assembly unit of the system into the cell comprises electroporation, microinjection, or a lipophilic carrier.  
   
   
       44 . The method of  claim 39 , wherein the step of synthesizing the biological material is initiated by a signal from a user operating a device separated from the system, wherein the user uses the device to send a signal to a receiver located in the central unit of the system.  
   
   
       45 . The method of  claim 39 , wherein the computer resides inside the central unit.  
   
   
       46 . A cell comprising a system comprising: 
 a central unit responsive to instructions to control an assembly unit; and    an assembly unit electrically connected to the central unit, the assembly unit being configured to synthesize biological material based on the instructions,    wherein the instructions are executed by a computer.    
   
   
       47 . The cell of  claim 46 , wherein the computer resides inside the central unit.  
   
   
       48 . The cell of  claim 46 , wherein the computer resides outside the central unit and outside the cell.  
   
   
       49 . The cell of  claim 46 , further comprising a repository unit attached to the assembly unit.  
   
   
       50 . The cell of  claim 46 , wherein the assembly unit comprises one or more of an input channel and an output channel on the assembly unit.  
   
   
       51 . The cell of  claim 48 , wherein the computer comprises one or more of a transmitter, software, and a database.  
   
   
       52 . The cell of  claim 48 , wherein the central unit comprises one or more of a memory, a receiver, an engine, and an antenna.  
   
   
       53 . The cell of  claim 49 , wherein the repository unit comprises one or more different types of monomeric biological components.  
   
   
       54 . The cell of  claim 53 , wherein the monomeric biological components include one or more of a nucleotide, amino acid, and tRNA.  
   
   
       55 . The cell of  claim 54 , wherein each tRNA is attached to an amino acid.  
   
   
       56 . The cell of  claim 46 , wherein the cell originates from a mammal.  
   
   
       57 . The cell of  claim 46 , wherein the cell originates from a human, mouse, rat, monkey, dog, cat, or rabbit.  
   
   
       58 . The cell of  claim 46 , wherein the cell is in a tissue of a human.  
   
   
       59 . A method of treating a human comprising administering a system to the human, wherein the system comprises: 
 a central unit responsive to instructions to control an assembly unit, and    an assembly unit electrically connected to the central unit, the assembly unit being configured to synthesize biological material based on the instructions,    wherein the instructions are executed by a computer.    
   
   
       60 . The method of  claim 59 , wherein the computer resides inside the central unit.  
   
   
       61 . The method of  claim 59 , wherein the computer resides outside the central unit and outside the cell.  
   
   
       62 . The method of  claim 59 , wherein the system further comprises a repository unit attached to the assembly unit.  
   
   
       63 . The method of  claim 59 , wherein the assembly unit comprises one or more of an input channel and an output channel.  
   
   
       64 . The method of  claim 59 , wherein the computer comprises one or more of a transmitter, software, and a database.  
   
   
       65 . The method of  claim 59 , wherein the central unit comprises one or more of a memory, a receiver, an engine, and an antenna.  
   
   
       66 . The method of  claim 64 , wherein the database comprises one or more of DNA sequence information, RNA sequence information, and polypeptide sequence information.  
   
   
       67 . The method of  claim 62 , wherein the repository unit comprises one or more different types of monomeric biological components.  
   
   
       68 . The method of  claim 67 , wherein the monomeric biological components include one or more of a nucleotide, amino acid, and tRNA.  
   
   
       69 . The method of  claim 68 , wherein each tRNA is attached to an amino acid.  
   
   
       70 . The method of  claim 59 , wherein the human has a cancer, a tissue disorder, or a disorder of the nervous system.  
   
   
       71 . The method of  claim 59 , wherein the system is administered by tissue graft, microprojectile technology, or by a lipophilic carrier.  
   
   
       72 . A method of treating a human comprising administering a cell comprising a system comprising: 
 a central unit responsive to instructions to control an assembly unit; and    an assembly unit electrically connected to the central unit, the assembly unit being configured to synthesize biological material based on the instructions,    wherein the instructions are generated by a computer.    
   
   
       73 . The method of  claim 72 , wherein the computer resides inside the central unit.  
   
   
       74 . The method of  claim 72 , wherein the computer resides outside the central unit and outside the human.  
   
   
       75 . The method of  claim 72 , wherein the system further comprises a repository unit attached to the assembly unit.  
   
   
       76 . The method of  claim 72 , wherein the assembly unit of the system comprises one or more of an input channel and an output channel on the assembly unit.  
   
   
       77 . The method of  claim 72 , wherein the computer comprises one or more of a transmitter, software, and a database.  
   
   
       78 . The method of  claim 72 , wherein the central unit comprises one or more of a memory, a receiver, an engine and an antenna.  
   
   
       79 . The method of  claim 77 , wherein the database comprises DNA sequence information, RNA sequence information, and polypeptide sequence information.  
   
   
       80 . The method of  claim 75 , wherein the repository unit comprises one or more different types of monomeric biological components.  
   
   
       81 . The method of  claim 80 , wherein the monomeric biological components include one or more of a nucleotide, amino acid, and tRNA.  
   
   
       82 . The method of  claim 81 , wherein each tRNA is attached to an amino acid.  
   
   
       83 . The method of  claim 72 , wherein the human has a cancer, a tissue disorder, or a disorder of the nervous system.  
   
   
       84 . The method of  claim 72 , wherein the cell is administered by tissue graft.

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