US2006286157A1PendingUtilityA1

Protein mixtures for wound healing

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Assignee: ZIMMER ORTHOBIOLOGICS INCPriority: Jun 28, 2000Filed: Jun 8, 2006Published: Dec 21, 2006
Est. expiryJun 28, 2020(expired)· nominal 20-yr term from priority
Inventors:Rama AkellaJohn Ranieri
A61P 43/00A61K 38/1875A61P 17/02Y10S530/84
52
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Claims

Abstract

A protein mixture that is useful in the treatment of wounds, where the mixture is isolated from bone or is produced from recombinant proteins and may include two or more of BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, TGF-β1, TGF-β2, TGF-β3, and FGF-1.

Claims

exact text as granted — not AI-modified
1 .- 24 . (canceled)  
     
     
         25 . A method of promoting the healing of a skin wound comprising applying to the skin wound an effective skin wound healing amount of a composition comprising: 
 a mixture of osteogenic proteins in which BMP-3 is the growth factor present in highest concentration; and    a pharmaceutically acceptable carrier.    
     
     
         26 . The method of  claim 25 , wherein at least one of the mixture of osteogenic proteins is derived from bone.  
     
     
         27 . The method of  claim 26 , wherein the bone comprises bovine bone.  
     
     
         28 . The method of  claim 26 , wherein the bone comprises demineralized bone.  
     
     
         29 . The method of  claim 25 , wherein the composition further comprises at least one growth factor selected from the group consisting of FGF-1, TGF-β1, TGF-β2 and TGF-β3.  
     
     
         30 . The method of  claim 25 , wherein the composition further comprises TGF-β2.  
     
     
         31 . The method of  claim 30 , wherein the composition further comprises BMP-6.  
     
     
         32 . The method of  claim 25 , wherein the composition further comprises BMP-6.  
     
     
         33 . The method of  claim 25 , wherein the composition further comprises BMP-2.  
     
     
         34 . The method of  claim 25 , wherein the composition further comprises at least one growth factor selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6, and BMP-7.  
     
     
         35 . A method of promoting skin wound healing comprising applying to the skin wound a composition comprising a mixture of growth factors comprising BMP-2, BMP-3, BMP-7, and TGF-β1 in a pharmaceutically acceptable carrier.  
     
     
         36 . The method of  claim 35 , wherein at least one of the mixture of growth factors is derived from bone.  
     
     
         37 . The method of  claim 36 , wherein the bone comprises bovine bone.  
     
     
         38 . The method of  claim 36 , wherein the bone comprises demineralized bone.  
     
     
         39 . The method of  claim 35 , wherein the composition further comprises at least one growth factor selected from the group consisting of FGF-1, TGF-β2 and TGF-β3.  
     
     
         40 . The method of  claim 35 , wherein the composition further comprises FGF-1.  
     
     
         41 . The method of  claim 35 , wherein the composition further comprises BMP-4.  
     
     
         42 . The method of  claim 35 , wherein the composition further comprises BMP-5.  
     
     
         43 . The method of  claim 35 , wherein the composition further comprises BMP-6.  
     
     
         44 . A method of promoting skin wound healing comprising applying to the skin wound a composition comprising a mixture of growth factors comprising BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, TGF-β1, TGF-β2, TGF-β3 and FGF-1 in a pharmaceutically acceptable carrier.

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