Human ccv polypeptides

Abstract

The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

1 . An isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a nucleotide sequence encoding a polypeptide selected from the group consisting of: 
 (a) the polypeptide shown in SEQ ID NO:2;    (b) the polypeptide shown in SEQ ID NO:4;    (c) the mature polypeptide shown as residues 16-172 in SEQ ID NO:4;    (d) the polypeptide shown in SEQ ID NO:6;    (e) the mature polypeptide shown as residues 16-88 in SEQ ID NO:6;    (f) the mature polypeptide shown as residues 23-88 in SEQ ID NO:6;    (g) the polypeptide shown in SEQ ID NO:8;    (h) the polypeptide shown in SEQ ID NO:10;    (i) the polypeptide shown in SEQ ID NO:12;    (j) the polypeptide shown in SEQ ID NO:14;    (k) the polypeptide shown in SEQ ID NO:16;    (l) the polypeptide shown in SEQ ID NO:18;    (m) the polypeptide shown in SEQ ID NO:20;    (n) the mature polypeptide shown as residues 16-528 in SEQ ID NO:20;    (o) the polypeptide shown in SEQ ID NO:22; and    (p) the polypeptide shown in SEQ ID NO:24.    
     
     
         2 . The nucleic acid molecule of  claim 1  comprising a nucleotide sequence which is at least 95% identical to a nucleotide sequence selected from the group consisting of: SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:17, SEQ ID NO:19, SEQ ID NO:21, and SEQ ID NO:23.  
     
     
         3 . An isolated nucleic acid molecule of  claim 3  comprising a nucleotide sequence which is at least 95% identical to a sequence of at least about 500 contiguous nucleotides in the nucleotide sequence of SEQ ID NO:X.  
     
     
         4 . An isolated nucleic acid molecule which hybridizes under stringent hybridization conditions to a nucleic acid molecule of  claim 1 , wherein said nucleic acid molecule which hybridizes does not hybridize under stringent hybridization conditions to a nucleic acid molecule having a nucleotide sequence consisting of only A residues or of only T residues.  
     
     
         5 . An isolated nucleic acid molecule of  claim 6  comprising a nucleotide sequence which is at least 95% identical to sequence of at least 500 contiguous nucleotides in the nucleotide sequence encoded by said human cDNA clone.  
     
     
         6 . An isolated polypeptide comprising an amino acid sequence which is identical to a sequence of at least about 10 contiguous amino acids in the amino acid sequence of SEQ ID NO:Y wherein Y is any integer as defined in Table 1.  
     
     
         7 . An isolated polypeptide of  claim 6  comprising an amino acid sequence at least 95% identical to the complete amino acid sequence of SEQ ID NO:Y.  
     
     
         8 . An isolated polypeptide comprising an amino acid sequence identical to a sequence of at least about 10 contiguous amino acids in the complete amino acid sequence of a secreted protein encoded by a human cDNA clone identified by a cDNA Clone Identifier in Table 1 and contained in the deposit with the ATCC Deposit Number shown for said cDNA clone in Table 1.  
     
     
         9 . A method of making a recombinant vector comprising inserting an isolated nucleic acid molecule of  claim 1  into a vector.  
     
     
         10 . A recombinant vector produced by the method of  claim 9 .  
     
     
         11 . A method of making a recombinant host cell comprising introducing a vector of  claim 10  into a host cell.  
     
     
         12 . A recombinant host cell produced by the method of  claim 12 .  
     
     
         13 . A method of making an isolated polypeptide comprising culturing a recombinant host cell of  claim 12  under conditions such that said polypeptide is expressed and recovering said polypeptide.  
     
     
         14 . An isolated polypeptide produced by the method of  claim 13 .  
     
     
         15 . An isolated antibody capable of specifically binding to a polypeptide of  claim 6.