Wound dressings containing complexes of transition metals and alginate for elastase sequestering

Abstract

Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration.

1 . A wound dressing, comprising: 
 a phosphorylated polysaccharide substrate complexed with at least one transition metal; and    an alginate coating.    
   
   
       2 . The wound dressing of  claim 1  wherein said phosphorylated polysaccharide is selected from the group consisting of phosphorylated cotton and phosphorylated gauze.  
   
   
       3 . The wound dressing of  claim 1  wherein said alginate coating is crosslinked.  
   
   
       4 . The wound dressing of  claim 1  wherein said alginate coating is silver alginate.  
   
   
       5 . The wound dressing of  claim 1  wherein the transition metal is selected from silver and copper.  
   
   
       6 . A wound dressing comprising: 
 a polysaccharide substrate; and    an alginate coating mixed with at least one transition metal.    
   
   
       7 . A method for treating a wound, comprising: 
 contacting a wound with a wound dressing comprising a polysaccharide substrate with an alginate coating;    absorbing wound fluid with said wound dressing; and    sequestering elastase from said wound.    
   
   
       8 . The method of  claim 7  wherein said polysaccharide substrate is phosphorylated and is complexed with at least one transition metal.  
   
   
       9 . The method of  claim 7  wherein said alginate coating is mixed with at least one transition metal