Particles for inhalation having sustained release properties

Abstract

The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

1 . Biocompatible particles for delivery of a therapeutic, prophylactic or diagnostic agent to the pulmonary system; wherein the particles have a tap density of less than 0.4 g/cm 3 , the particle size is about 5-10 μm, and the particles have a mean aerodynamic diameter between about 1 μm and about 5 μm.  
     
     
         2 . The particles of  claim 1 , wherein the particles have a mean aerodynamic diameter of about 1-3 μm.  
     
     
         3 . The particles of  claim 1 , wherein the particles have a mean aerodynamic diameter of about 1 μm.  
     
     
         4 . The particles of  claim 1 , wherein the agent is a protein.