Methods of reducing the perception of body odors with olfactory adaptation and cross-adapting agents

Abstract

Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants. Methods of making deodorant compositions are also provided wherein a cross-adapting agent, alone or in combination with other such agents, are included in an amount effective to reduce perception of malodor.

1 - 36 . (canceled)  
   
   
       37 . A method for reducing the perception of malodor by males or females comprising administering a deodorant composition comprising a cross-adapting agent in an amount effective to reduce perception of male or female malodor, wherein the cross-adapting agent is selected from the group consisting of: agrumex (2-tert-butyl-cyclohexyl acetate), C14 aldehyde (4-undecanolide), ambrettolide (cyclohexadec-7-enolide), anisyl aldehyde (4-methoxy-benzaldehyde), calone 1951 (7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one), cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, Δ-damascone (1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one), datilat (1-cyclohexyl-ethyl-2-butenoate, dynascone, evernyl (methyl-2,4-dihydroxy-3,6-methyl-benzoate), 2,6,1 0-trimethyl-9-undecenal, floropal (2,4,6-trimethyl-4-phenyl-1,3-dioxane), oxacyclohexadecen-2-one, cyclohexadecenone, cis-3-hexenol, 2-acetyl-1,2,3,4,6,7,8-octahydro-2,3,8,8-tetramethyl naphalene, isoananat (acetic acid (cyclohexyloxy-2-propenyl-ester), isoraldeine 70 (4-(2,6,6-trimethyl-2-cyclohexen-yl-3-methyl-3-buten-2-one), lilial (4-tert-butyl-α-methyl-hydrocinnamic aldehyde), 2,2-dimethyl-3-(methylphenyl)propanol, mugetanol (1-(4-isopropyl-cyclohexyl)-ethanol), nerolione (1-(3-bethyl-2-benzofuranyl)-ethanone), oryclone special (4-tert-butyl-cyclohexylacetate), rosaphen (2-methyl-5-phenyl-pentan-1-ol), sandel, sandolene (2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol), timbranol (α,β-2,2,6-pentamethyl-cyclohexane propanol), tonalide (7-acetyl 1,1,3,4,4,6-hexamethyl-and 6-acetyl 1,1,2,4,4,7-hexamethyltetraline), vertocitral (2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde), and combinations thereof.  
   
   
       38 . The method of  claim 37  wherein the cross-adapting agent is selected from the group consisting of: agrumex (2-tert-butyl-cyclohexyl acetate), C14 aldehyde (4-undecanolide), ambrettolide (cyclohexadec-7-enolide), anisyl aldehyde (4-methoxy-benzaldehyde), calone 1951 (7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one), cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, Δ-damascone (1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one), dynascone, evernyl (methyl-2,4-dihydroxy-3,6-methyl-benzoate), 2,6,10-trimethyl-9-undecenal, floropal (2,4,6-trimethyl-4-phenyl-1,3-dioxane), oxacyclohexadecen-2-one, cyclohexadecenone, cis-3-hexenol, isoananat (acetic acid (cyclohexyloxy-2-propenyl-ester), isoraldeine 70 (4-(2,6,6-trimethyl-2-cyclohexen-yl-3-methyl-3-buten-2-one), lilial (4-tert-butyl-a-methyl-hydrocinnamic aldehyde), 2,2-dimethyl-3-(methylphenyl)propanol, mugetanol (1-(4-isopropyl-cyclohexyl)-ethanol), nerolione (1-(3-bethyl-2-benzofuranyl)-ethanone), oryclone special (4-tert-butyl-cyclohexylacetate), rosaphen (2-methyl-5-phenyl-pentan-1-ol), sandel, sandolene (2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol), tonalide (7-acetyl 1,1,3,4,4,6-hexamethyl-and 6-acetyl 1,1,2,4,4,7-hexamethyltetraline), vertocitral (2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde), and combinations thereof.  
   
   
       39 . The method of  claim 37  wherein the cross-adapting agent is selected from the group consisting of: ambrettolide (cyclohexadec-7-enolide), calone 1951 (7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one), cpd supra, oxacyclohexadecen-2-one, cyclohexadecenone, 2-acetyl-1,2,3,4,6,7,8-octahydro-2,3,8,8-tetramethyl naphalene, lilial (4-tert-butyl-α-methyl-hydrocinnamic aldehyde), rosaphen (2-methyl-5-phenyl-pentan-1-ol), vertocitral (2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde), and combinations thereof.  
   
   
       40 . A method for reducing the perception of malodor by males or females comprising administering a deodorant composition comprising a cross-adapting agent in an amount effective to reduce perception of male or female malodor, wherein the cross-adapting agent is selected from the group consisting of: l-carvone ((R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone), citronellol 950 (3,7-dimethyl-6-octen-1-ol), citrylal 1,1-diethoxy-3,7-dimethyl-2,6-octadiene), α-damascone (1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one), dihydromyrcenol (2,6-mimethyl-7-octen-2-ol), ethyl vanillin (3-ethoxy-4-hydroxy-benzaldehyde), methyl dihydro jasmonate, hexyl salicylate (hexyl-2-hydroxy-benzoate), hexylcinnamic aldehyde (α-hexyl-cinnamic aldehyde), 4-(4-hydroxy-4-methylpentyl)-3-cyclohexenE-1-carboxaldehyde, menthyl acetate rf (DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate), patchouli oil, rose oxide hc (4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane), and combinations thereof.  
   
   
       41 . A method for reducing the perception of male malodor by males comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce the perception of male malodor by males, wherein the cross-adapting agent is selected from the group consisting of: agrumex (2-tert-butyl-cyclohexyl acetate), C14 aldehyde (4-undecanolide), l-carvone ((R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone), cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, Δ-damascone (1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one), dynascone, floropal (2,4,6-trimethyl-4-phenyl-1,3-dioxane), oxacyclohexadecen-2-one, cis-3-hexenol, isoananat (acetic acid (cyclohexyloxy-2-propenyl-eater), mugetanol (1-(4-isopropyl-cyclohexyl)-ethanol), nerolione (1-(3-bethyl-2-benzofuranyl)-ethanone), oryclone special (4-tert-butyl-cyclohexylacetate), rosaphen (2-methyl-5-phenyl-pentan-1-ol), sandel, sandolene (2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol), tetrahydro linalool (3,7-dimethyl-3-octanol), tonalide (7-acetyl 1,1,3,4,4,6-hexamethyl-and 6-acetyl 1,1,2,4,4,7-hexamethyltetraline), vertocitral (2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde), and combinations thereof.  
   
   
       42 . A method for reducing the perception of male malodor by males comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce the perception of male malodor by males, wherein the cross-adapting agent is selected from the group consisting of: citronellol 950 (3,7-dimethyl-6-octen-1-ol), citrylal 1,1-diethoxy-3,7-dimethyl-2,6-octadiene), dihydromyrcenol (2,6-mimethyl-7-octen-2-ol), hexylcinnamic aldehyde (α-hexyl-cinnamic aldehyde), menthyl acetate rf (DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate), and combinations thereof.  
   
   
       43 . A method for reducing the perception of male malodor by females comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce the perception of male malodor by females, wherein the cross-adapting agent is selected from the group consisting of: l-carvone ((R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone), 2,4,4,7-tetramethyl-oct-6-en-3-one, Δ-damascone (1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one), cis-3-hexenol, vertocitral (2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde), and combinations thereof.  
   
   
       44 . A method for reducing the perception of male malodor by females comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce the perception of male malodor by females, wherein the cross-adapting agent is selected from the group consisting of: citronellol 950 (3,7-dimethyl-6-octen-1-ol), citrylal 1,1-diethoxy-3,7-dimethyl-2,6-octadiene), dihydromyrcenol (2,6-mimethyl-7-octen-2-ol), hexylcinnamic aldehyde (α-hexyl-cinnamic aldehyde), menthyl acetate rf (DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate)rose oxide hc (4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane), and combinations thereof.  
   
   
       45 . A method for reducing the perception of female malodor by males comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce the perception of female malodor by males, wherein the cross-adapting agent is selected from the group consisting of: C14 aldehyde (4-undecanolide), anisyl aldehyde (4-methoxy-benzaldehyde), calone 1951 (7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one), l-carvone ((R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone), cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, dynascone, 2,6,10-trimethyl-9-undecenal, floropal (2,4,6-trimethyl-4-phenyl-1,3-dioxane), cyclohexadecenone, cis-3-hexenol, isoananat (acetic acid (cyclohexyloxy-2-propenyl-ester), isoraldeine 70 (4-(2,6,6-trimethyl-2-cyclohexen-yl-3-methyl-3-buten-2-one), lilial (4-tert-butyl-α-methyl-hydrocinnamic aldehyde), 2,2-dimethyl-3-(methylphenyl)propanol, oryclone special (4-tert-butyl-cyclohexylacetate), rosaphen (2-methyl-5-phenyl-pentan-1-ol), sandolene (2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-vertocitral (2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde), and combinations thereof.  
   
   
       46 . A method for reducing the perception of female malodor by males comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce the perception of female malodor by males, wherein the cross-adapting agent is selected from the group consisting of: citronellol 950 (3,7-dimethyl-6-octen-1-ol), dihydromyrcenol (2,6-mimethyl-7-octen-2-ol), ethyl vanillin (3-ethoxy-4-hydroxy-benzaldehyde), hexylcinnamic aldehyde (α-hexyl-cinnamic aldehyde), 4-(4-hydroxy-4-methylpentyl)-3-cyclohexenE-1-carboxaldehyde, menthyl acetate rf (DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate), patchouli oil, rose oxide hc (4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane), and combinations thereof.  
   
   
       47 . A method for reducing the perception of female malodor by females comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce the perception of female malodor by females, wherein the cross-adapting agent is selected from the group consisting of: agrumex (2-tert-butyl-cyclohexyl acetate), C14 aldehyde (4-undecanolide), ambrettolide (cyclohexadec-7-enolide), anisyl aldehyde (4-methoxy-benzaldehyde), calone 1951 (7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one), l-carvone ((R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone), cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, dynascone, eugenol (2-methoxy-4-allyl-phenol), evernyl (methyl-2,4-dihydroxy-3,6-methyl-benzoate), floropal (2,4,6-trimethyl-4-phenyl-1,3-dioxane), oxacyclohexadecen-2-one cis-3-hexenol, sandolene (2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol), vertocitral (2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde), and combinations thereof.  
   
   
       48 . A method for reducing the perception of female malodor by females comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce the perception of female malodor by females, wherein the cross-adapting agent is selected from the group consisting of: citronellol 950 (3,7-dimethyl-6-octen-1-ol), α-damascone (1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one), dihydromyrcenol (2,6-mimethyl-7-octen-2-ol), hexyl salicylate (hexyl-2-hydroxy-benzoate), menthyl acetate rf (DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate), patchouli oil, rose oxide hc (4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane), and combinations thereof.  
   
   
       49 . A method for reducing the perception of male malodor comprising administering a deodorant composition comprising an amount of a cross-adapting agent effective to reduce perception of male malodor, and wherein the cross-adapting agent is selected from the group consisting of: E-, Z-isomers (3:1) of 3-methyl-2-octenoic acid ethyl esters, E-isomer of 3-methyl-2-pentenoic acid ethyl ester, Z-isomer of 3-methyl-2-pentenoic acid ethyl ester, and combinations thereof.  
   
   
       50 . The method of  claim 49 , reducing the perception of male malodor by males, wherein the deodorant composition further comprises a second cross-adapting agent selected from the group consisting of: 2-tert-butyl-cyclohexyl acetate, 4-undecanolide, (R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone, cedryl methyl ether, 3,7-dimethyl-6-octen-1-ol, citrylal 1,1-diethoxy-3,7-dimethyl-2,6-octadiene), 2,4,4,7-tetramethyl-oct-6-en-3-one, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one), 2,6-mimethyl-7-octen-2-ol, dynascone, 2-methoxy-4-allyl-phenol, 2,4,6-trimethyl-4-phenyl-1,3-dioxane, oxacyclohexadecen-2-one, cis-3-hexenol, α-hexyl-cinnamic aldehyde, acetic acid (cyclohexyloxy-2-propenyl-ester), DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate, 1-(4-isopropyl-cyclohexyl)-ethanol), 1-(3-bethyl-2-benzofuranyl)-ethanone), H&R odor neutralizer (D61012), 4-tert-butyl-cyclohexylacetate, phenylethyl alcohol, 2-methyl-5-phenyl-pentan-1-ol, sandel, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, 3,7-dimethyl-3-octanol), 7-acetyl 1,1,3,4,4,6-hexamethyl-and 6-acetyl 1,1,2,4,4,7-hexamethyltetraline, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       51 . The method of  claim 49 , reducing the perception of male malodor by females, wherein the deodorant composition further comprises a second cross-adapting agent selected from the group consisting of: (R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone, 3,7-dimethyl-6-octen-1-ol, 1,1-diethoxy-3,7-dimethyl-2,6-octadiene, 2,4,4,7-tetramethyl-oct-6-en-3-one, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one, 2,6-mimethyl-7-octen-2-ol, cis-3-hexenol, α-hexyl-cinnamic aldehyde, DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate phenylethyl alcohol, 4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       52 . A method for reducing the perception of female malodor comprising administering a deodorant composition comprising a cross-adapting agent in an amount effective to reduce perception of female malodor, and wherein the cross-adapting agent is selected from the group consisting of: E-, Z-isomers (3:1) of 3-methyl-2-octenoic acid ethyl esters, E-isomer of 3-methyl-2-pentenoic acid ethyl ester, E-isomer of 3-methyl-2-octenoic acid ethyl ester, Z-isomer of 3-methyl-2-pentenoic acid ethyl ester, and combinations thereof.  
   
   
       53 . The method of  claim 52 , reducing the perception of female malodor by males, wherein the deodorant composition further comprises a second cross-adapting agent selected from the group consisting of: 4-undecanolide, 4-methoxy-benzaldehyde, 7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one, (R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone, cedryl methyl ether, 3,7-dimethyl-6-octen-1-ol, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, 2,6-mimethyl-7-octen-2-ol, dynascone, 3-ethoxy-4-hydroxy-benzaldehyde, 2-methoxy-4-allyl-phenol, 2,6,10-trimethyl-9-undecenal, 2,4,6-trimethyl-4-phenyl-1,3-dioxane, cyclohexadecenone, cis-3-hexenol, α-hexyl-cinnamic aldehyde, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one, acetic acid (cyclohexyloxy-2-propenyl-ester, 4-(2,6,6-trimethyl-2-cyclohexen-yl-3-methyl-3-buten-2-one, 4-tert-butyl-α-methyl-hydrocinnamic aldehyde, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexenE-1-carboxaldehyde, 2,2-dimethyl-3-(methylphenyl)propanol, DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate, 4-tert-butyl-cyclohexylacetate, patchouli oil, phenylethyl alcohol, 2-methyl-5-phenyl-pentan-1-ol, 4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       54 . The method of  claim 52 , reducing the perception of female malodor by females, wherein the deodorant composition further comprises a second cross-adapting agent selected from the group consisting of: 2-tert-butyl-cyclohexyl acetate, 4-undecanolide, cyclohexadec-7-enolide, 4-methoxy-benzaldehyde, 7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one, (R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone, cedryl methyl ether, 3,7-dimethyl-6-octen-1-ol, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one, 2,6-mimethyl-7-octen-2-ol, dynascone, 2-methoxy-4-allyl-phenol, methyl-2,4-dihydroxy-3,6-methyl-benzoate, 2,4,6-trimethyl-4-phenyl-1,3-dioxane, oxacyclohexadecen-2-one, cis-3-hexenol, hexyl-2-hydroxy-benzoate, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one, DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate, patchouli oil, 4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       55 . A method of blocking male malodor comprising administering a deodorant composition comprising a cross-adapting agent in an amount effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants, and wherein the cross-adapting agent is selected from the group consisting of: 2-tert-butyl-cyclohexyl acetate, 4-undecanolide, cyclohexadec-7-enolide, (R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone, cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one, 1-cyclohexyl-ethyl-2-butenoate, dynascone, 2,6,1 0-trimethyl-9-undecenal, 2,4,6-trimethyl-4-phenyl-1,3-dioxane, oxacyclohexadecen-2-one, cis-3-hexenol, 2-acetyl-1,2,3,4,6,7,8-octahydro-2,3,8,8-tetramethyl naphalene, acetic acid (cyclohexyloxy-2-propenyl-ester, 1-(4-isopropyl-cyclohexyl)-ethanol, (1-(3-bethyl-2-benzofuranyl)-ethanone), 4-tert-butyl-cyclohexylacetate, 2-methyl-5-phenyl-pentan-1-ol, sandel, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, α,β-2,2,6-pentamethyl-cyclohexane propanol, 7-acetyl 1,1,3,4,4,6-hexamethyl-and 6-acetyl 1,1,2,4,4,7-hexamethyltetraline, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       56 . The method of  claim 55 , wherein the cross-adapting agent is selected from the group consisting of: 2-tert-butyl-cyclohexyl acetate, 4-undecanolide, (R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone, cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one, dynascone, 2,4,6-trimethyl-4-phenyl-1,3-dioxane, oxacyclohexadecen-2-one, cis-3-hexenol, acetic acid cyclohexyloxy-2-propenyl-ester, 1-(4-isopropyl-cyclohexyl)-ethanol, 1-(3-bethyl-2-benzofuranyl)-ethanone, 4-tert-butyl-cyclohexylacetate, (2-methyl-5-phenyl-pentan-1-ol, sandel, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, 7-acetyl 1,1,3,4,4,6-hexamethyl-and 6-acetyl 1,1,2,4,4,7-hexamethyltetraline, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       57 . The method of  claim 55  wherein the cross-adapting agent is selected from the group consisting of: oxacyclohexadecen-2-one, rosaphen 2-methyl-5-phenyl-pentan-1-ol, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       58 . A method of blocking male malodor comprising administering a deodorant composition comprising a cross-adapting agent in an amount effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants, and wherein the cross-adapting agent is selected from the group consisting of: 3,7-dimethyl-6-octen-1-ol, 1,1-diethoxy-3,7-dimethyl-2,6-octadiene, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one, 2,6-mimethyl-7-octen-2-ol, methyl dihydro jasmonate, hexyl-2-hydroxy-benzoate, α-hexyl-cinnamic aldehyde, DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate, 4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane, and combinations thereof.  
   
   
       59 . A method of blocking female malodor comprising administering a deodorant composition comprising a cross-adapting agent in an amount effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants, wherein the cross-adapting agent is selected from the group consisting of: 2-tert-butyl-cyclohexyl acetate, 4-undecanolide, cyclohexadec-7-enolide, 4-methoxy-benzaldehyde, 7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one, (R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone, cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, dynascone, methyl-2,4-dihydroxy-3,6-methyl-benzoate, 2,6,10-trimethyl-9-undecenal, 2,4,6-trimethyl-4-phenyl-1,3-dioxane, oxacyclohexadecen-2-one, cyclohexadecenone, cis-3-hexenol, 2-acetyl-1,2,3,4,6,7,8-octahydro-2,3,8,8-tetramethyl naphalene, acetic acid (cyclohexyloxy-2-propenyl-ester, 4-(2,6,6-trimethyl-2-cyclohexen-yl-3-methyl-3-buten-2-one, 4-tert-butyl-a-methyl-hydrocinnamic aldehyde, 2,2-dimethyl-3-(methylphenyl)propanol, 4-tert-butyl-cyclohexylacetate, 2-methyl-5-phenyl-pentan-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       60 . The method of  claim 59  wherein the cross-adapting agent is selected from the group consisting of: 2-tert-butyl-cyclohexyl acetate, 4-undecanolide, cyclohexadec-7-enolide, 4-methoxy-benzaldehyde, 7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one, (R)-(−)-5-isopropenyl-2-methyl-2-cyclohexanone, cedryl methyl ether, 2,4,4,7-tetramethyl-oct-6-en-3-one, cpd supra, dynascone, methyl-2,4-dihydroxy-3,6-methyl-benzoate, 2,6,10-trimethyl-9-undecenal, 2,4,6-trimethyl-4-phenyl-1,3-dioxane, oxacyclohexadecen-2-one, cyclohexadecenone, cis-3-hexenol, acetic acid cyclohexyloxy-2-propenyl-ester, 4-(2,6,6-trimethyl-2-cyclohexen-yl-3-methyl-3-buten-2-one, 4-tert-butyl-α-methyl-hydrocinnamic aldehyde, 2,2-dimethyl-3-(methylphenyl)propanol, 4-tert-butyl-cyclohexylacetate, 2-methyl-5-phenyl-pentan-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       61 . The method of  claim 59  wherein the cross-adapting agent is selected from the group consisting of: cyclohexadec-7-enolide, 7-methyl-3,4-dihydro-2H-1,5-benzodioxepine-3-one, cpd supra, oxacyclohexadecen-2-one, cyclohexadecenone, 4-tert-butyl-α-methyl-hydrocinnamic aldehyde, 2-methyl-5-phenyl-pentan-1-ol, 2,4 and 3,5-dimethyl-3-cyclo-hexane-1-carboxaldehyde, and combinations thereof.  
   
   
       62 . A method of blocking female malodor comprising administering a deodorant composition comprising a cross-adapting agent in an amount effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants, wherein the cross-adapting agent is selected from the group consisting of: 3,7-dimethyl-6-octen-1-ol, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one, 2,6-mimethyl-7-octen-2-ol, 3-ethoxy-4-hydroxy-benzaldehyde, 2-methoxy-4-allyl-phenol, methyl dihydro jasmonate, hexyl-2-hydroxy-benzoate, α-hexyl-cinnamic aldehyde, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexenE-1-carboxaldehyde, DL-5-methyl-2-(1-methyl-ethyl)-cyclohexyl acetate, patchouli oil, 4-methyl-2-(2-methylpropan-1-yl)-tetrahydro-pyrane, and combinations thereof.  
   
   
       63 - 68 . (canceled)