US2007026018A1PendingUtilityA1

Methods for treating, preventing and diagnosing Helicobacter infection

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Assignee: ELLIS JOHNPriority: Feb 3, 2003Filed: Aug 3, 2005Published: Feb 1, 2007
Est. expiryFeb 3, 2023(expired)· nominal 20-yr term from priority
Inventors:John EllisGeorge KrakowkaKathryn EatonJoel Flores
A61P 31/04A61P 1/04C07K 14/205A61K 39/105G01N 33/56911
37
PatentIndex Score
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Claims

Abstract

Compositions and methods for treating, preventing and diagnosing Helicobacter infection are disclosed. The methods use proteins and/or nucleic acids derived from Helicobacter cerdo , a new pathogen isolated from swine.

Claims

exact text as granted — not AI-modified
1 . A composition comprising a pharmaceutically acceptable vehicle and at least one  Helicobacter cerdo  immunogen.  
   
   
       2 . The composition of  claim 1 , wherein the at least one  H. cerdo  immunogen is provided in an  H. cerdo  lysate.  
   
   
       3 . The composition of  claim 2 , wherein the  H. cerdo  lysate is produced by proteolytic digestion of  H. cerdo  bacteria.  
   
   
       4 . The composition of  claim 1 , further comprising an adjuvant.  
   
   
       5 . A method of treating or preventing a  Helicobacter  infection in a vertebrate subject comprising administering to said subject a therapeutically effective amount of the composition according to  claim 1 .  
   
   
       6 . The method of  claim 5 , wherein said vertebrate subject is a porcine subject.  
   
   
       7 . The method of  claim 6 , wherein the  Helicobacter  infection is a  Helicobacter  cerdo infection.  
   
   
       8 . The method of  claim 5 , wherein said composition is administered parenterally.  
   
   
       9 . A method of treating or preventing a  Helicobacter cerdo  infection in a porcine subject comprising parenterally administering to said subject a therapeutically effective amount of the composition according to  claim 1 .  
   
   
       10 . A method of producing the composition of  claim 1  comprising: 
 (a) providing at least one  Helicobacter cerdo  immunogen; and    (b) combining said  H. cerdo  immunogen with a pharmaceutically acceptable vehicle.    
   
   
       11 . The method of  claim 10 , wherein said at least one  H. cerdo  immunogen is provided in an  H. cerdo  lysate.  
   
   
       12 . The method of  claim 11 , wherein the  H. cerdo  lysate is produced by proteolytic digestion of  H. cerdo  bacteria.  
   
   
       13 . The method of  claim 10 , further comprising providing an adjuvant.  
   
   
       14 . A method of detecting  Helicobacter  infection in a vertebrate subject comprising: 
 (a) providing a biological sample from the subject; and    (b) reacting said biological sample with at least one  H. cerdo  immunogen, under conditions which allow  Helicobacter  antibodies, when present in the biological sample, to bind with said at least one immunogen,    thereby detecting the presence or absence of  Helicobacter  infection in the subject.    
   
   
       15 . The method of  claim 14  further comprising: 
 (c) removing unbound antibodies;    (d) providing one or more moieties capable of associating with said bound antibodies; and    (e) detecting the presence or absence of said one or more moieties, thereby detecting the presence or absence of  H. cerdo  infection.    
   
   
       16 . The method of  claim 15  wherein the detectable label is a fluorescer or an enzyme.  
   
   
       17 . The method of  claim 14 , wherein said at least one immunogen is provided in an  H. cerdo  lysate.  
   
   
       18 . The method of  claim 14 , wherein said biological sample is a porcine serum sample.  
   
   
       19 . A method of detecting  Helicobacter cerdo  infection in a porcine subject comprising: 
 (a) providing a biological sample from the subject; and    (b) reacting said biological sample with at least one  H. cerdo  immunogen, under conditions which allow  H. cerdo  antibodies, when present in the biological sample, to bind with said immunogen(s),    (c) removing unbound antibodies;    (d) providing one or more moieties capable of associating with said bound antibodies; and    (e) detecting the presence or absence of said one or more moieties, thereby detecting the presence or absence of  H. cerdo  infection.    
   
   
       20 . An antibody specific for a  Helicobacter cerdo  immunogen.  
   
   
       21 . The antibody of  claim 20 , wherein the antibody is a polyclonal antibody.  
   
   
       22 . The antibody of  claim 20 , wherein the antibody is a monoclonal antibody.  
   
   
       23 . A  Helicobacter cerdo  lysate comprising at least one  H. cerdo  immunogen.  
   
   
       24 . The  H. cerdo  lysate of  claim 23 , wherein the  H. cerdo  lysate is produced by proteolytic digestion of  H. cerdo  bacteria.

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