Triazole derivatives useful in therapy

Abstract

The invention provides compounds of formula I, R 1 —OP(O)(OH) 2   I wherein R 1 represents the non-hydroxy portion of a triazole antifungal compound of the type comprising a tertiary hydroxy group; or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful in the treatment of fungal infections, and have good aqueous solubility.

1 . A compound of formula I,  
         R 1 —OP(O)(OH) 2   I  wherein R 1  represents the non-hydroxy portion of a triazole antifungal compound of the type comprising a tertiary hydroxy group;    or a pharmaceutically acceptable salt thereof.    
     
     
         2 . A compound as claimed in  claim 1 , wherein R 1  is a group of formula Ia,  
       
         
           
           
               
               
           
         
         in which  
         R 2  represents phenyl substituted by one or more halogen atoms;  
         R 3  represents H or CH 3 ;  
         R 3a  represents H, or together with R 3  it may represent ═CH 2 ; and  
         R 4  represents a 5- or 6-membered nitrogen-containing heterocyclic ring which is optionally substituted by one or more groups selected from halogen, ═O, phenyl [substituted by a group selected from CN and (C 6 H 4 )—OCH 2 CF 2 CHF 2 ] or CH═CH—(C 6 H 4 )—OCH 2 CF 2 CHF 2 ; or phenyl substituted by one or more groups selected from halogen and methylpyrazolyl.  
       
     
     
         3 . A compound as claimed in  claim 2 , wherein R 2  is 2,4-difluorophenyl.  
     
     
         4 . A compound as claimed in  claim 3 , wherein R 3  is H or methyl.  
     
     
         5 . A compound as claimed in claims  4 , wherein R 4  represents or comprises a triazolyl, pyrimidinyl or thiazolyl group.  
     
     
         6 - 14 . (canceled)