Compounds and methods of use

Abstract

Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

1 - 40 . (canceled)  
   
   
       41 . A method of inhibiting cell proliferation which comprises administering an effective amount of a compound of the following formula I:  
     
       
         
         
             
             
         
       
       wherein A is O, S or NH;  
       wherein D is CR 1  or N;  
       wherein E is CR 2  or N;  
       wherein F is CR 3  or N;  
       wherein G is CR 4  or N;  
       wherein J is selected from NR 6 , S, O, and CR 1 ;  
       wherein K is selected from NR 6 , S, O, and CR 2 ;  
       wherein L is selected from NR 6 , S, O, and CR 3 ;  
       wherein Q is selected from hydroxy, —N(R 5 ) 2 , —NR 5 C(O)R 5 , —(C 1 -C 8 )alkyl-OR 5 , —(C 1 -C 8 )alkyl-S(O) n R 5 , —N(C 1 -C 8 -alkyl)-S(O) n R 5 , —NHS(O) n R 5 , aryl, a monocyclic or bicyclic, non-aromatic carbocyclic ring, heteroaryl and a monocyclic or bicyclic, non-aromatic heterocyclic ring; wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , —(C 1 -C 8 ) alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —O—C 1 -C 2 -alkyl-O—, —S(O) n R 5 , cyano, (C 1 -C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 10 )cycloalkyl, nitro, optionally substituted 4-7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5   1 —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5  and —C(O)R 5 ;  
       wherein W is thiazolyl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5   1  (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 -C 8 )alkylSO 2 R 5 , —(C 1 -C 8 )alkylSO 2 —(C 1 -C 8 )alkyl-R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —C(O)NR 5 R 5a , —CO 2 R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ;  
       wherein Z is selected from H, —N(R 5 ) 2 , —SR 5 , —OR 5 , —C(R 5 ) 3  and aryl; 
 wherein n is 0, 1 or 2;  
 wherein m is 0 or 1;  
 
       wherein R 1 , R 2 , R 3 , and R 4  are independently selected from H, —OR 5 , —OR 5a , halo, aryl, alkenyl, alkynyl, —NR 5   2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 4-10 membered heterocyclyl, —C(O)R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted arylalkyl, optionally substituted 4-10 membered heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; wherein R 1  and R 2  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; wherein R 2  and R 3  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; or wherein R 3  and R 4  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring;  
       wherein R 5  is independently selected from H, lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkyl-alkyl, and lower haloalkyl;  
       wherein R 5a  is alkylaminoalkyl;  
       wherein R 6  is selected from H, (C 1 -C 2 )alkyl, and a lone pair of electrons;  
       wherein a solid line with a dashed line (---) represents either a single or a double bond;  
       wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , or R 5  can optionally join with another R 1 , R 2 , R 3 , R 4 , or R 5  to form a 3-7 membered ring; and  
       wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, heterocyclyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , R 5 , Q and W is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, C 1 -C 6 )alkoxy, C 1 -C 6 )haloalkyl, di(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkyl, (C 1 -C 6 )hydroxyalkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl;  
       provided Z is not OH when Ar is aryl; further provided Q is not unsubstituted phenyl when W is thiazol-4-yl, when Z is H and when F is C—OCH 3 ; further provided Q is not 3,4-dimethoxyphenyl when W is thiazol-4-yl, when Z is H and when R 1 , R 2 , R 3  and R 4  are H; and further provided Q is not 3,4-dihydroxyphenyl when W is thiazol-2-yl, when Z is H and when R 1 , R 2 , R 3  and R 4  are H;  
       and pharmaceutically acceptable salts thereof.  
     
   
   
       42 . A method of treating cancer which comprises administering an effective amount of a compound of the following formula I:  
     
       
         
         
             
             
         
       
       wherein A is O, S or NH;  
       wherein D is CR 1  or N;  
       wherein E is CR 2  or N;  
       wherein F is CR 3  or N;  
       wherein G is CR 4  or N;  
       wherein J is selected from NR 6 , S, O, and CR 1 ;  
       wherein K is selected from NR 6 , S, O, and CR 2 ;  
       wherein L is selected from NR 6 , S, O, and CR 3 ;  
       wherein Q is selected from hydroxy, —N(R 5 ) 2 , —NR 5 C(O)R 5 , —(C 1 -C 8 )alkyl-OR 5 , —(C 1 -C 8 )alkyl-S(O) n R 5 , —N(C 1 -C 8 -alkyl)-S(O) n R 5 , —NHS(O) n R 5 , aryl, a monocyclic or bicyclic, non-aromatic carbocyclic ring, heteroaryl and a monocyclic or bicyclic, non-aromatic heterocyclic ring; wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —O—C 1 -C 2 -alkyl-O—, —S(O) n R 5 , cyano, (C 1 -C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 10 )cycloalkyl, nitro, optionally substituted 4-7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5 , —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5  and —C(O)R 5 ;  
       wherein W is thiazolyl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5 , (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 -C 8 )alkylSO 2 R 5 , —(C 1 -C 8 )alkylSO 2 —(C 1 -C 8 )alkyl-R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —C(O)NR 5 R 5a , —CO 2 R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ;  
       wherein Z is selected from H, —N(R 5 ) 2 , —SR 5 , —OR 5 , —C(R 5 ) 3  and aryl; 
 wherein n is 0, 1 or 2;  
 wherein m is 0 or 1;  
 
       wherein R 1 , R 2 , R 3 , and R 4  are independently selected from H, —OR 5 , —OR 5a , halo, aryl, alkenyl, alkynyl, —NR 5   2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 ) cycloalkyl, nitro, cyano, optionally substituted 4-10 membered heterocyclyl, —C(O)R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted arylalkyl, optionally substituted 4-10 membered heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; wherein R 1  and R 2  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; wherein R 2  and R 3  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; or wherein R 3  and R 4  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring;  
       wherein R 5  is independently selected from H, lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkyl-alkyl, and lower haloalkyl;  
       wherein R 5a  is alkylaminoalkyl;  
       wherein R 6  is selected from H, (C 1 -C 2 )alkyl, and a lone pair of electrons;  
       wherein a solid line with a dashed line (---) represents either a single or a double bond;  
       wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , or R 5  can optionally join with another R 1 , R 2 , R 3 , R 4 , or R 5  to form a 3-7 membered ring; and  
       wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, heterocyclyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , R 5 , Q and W is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, C 1 -C 6 )alkoxy, C 1 -C 6 )haloalkyl, di(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkyl, (C 1 -C 6 )hydroxyalkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl;  
       provided Z is not OH when Ar is aryl; further provided Q is not unsubstituted phenyl when W is thiazol-4-yl, when Z is H and when F is C—OCH 3 ; further provided Q is not 3,4-dimethoxyphenyl when W is thiazol-4-yl, when Z is H and when R 1 , R 2 , R 3  and R 4  are H; and further provided Q is not 3,4-dihydroxyphenyl when W is thiazol-2-yl, when Z is H and when R 1 , R 2 , R 3  and R 4  are H;  
       and pharmaceutically acceptable salts thereof.  
     
   
   
       43 . (canceled)  
   
   
       44 . A method of treating a neurological disorder which comprises administering an effective amount of a compound of the following formula I:  
     
       
         
         
             
             
         
       
       wherein A is O, S or NH;  
       wherein D is CR 1  or N;  
       wherein E is CR 2  or N;  
       wherein F is CR 3  or N;  
       wherein G is CR 4  or N;  
       wherein J is selected from NR 6 , S, O, and CR 1 ;  
       wherein K is selected from NR 6 , S, O, and CR 2 ;  
       wherein L is selected from NR 6 , S, O, and CR 3 ;  
       wherein Q is selected from hydroxy, —N(R 5 ) 2 , —NR 5 C(O)R 5 , —(C 1 -C 8 )alkyl-OR 5 , —(C 1 -C 8 )alkyl-S(O) n R 5 , —N(C 1 -C 8 -alkyl)-S(O) n R 5 , —NHS(O) n R 5 , aryl, a monocyclic or bicyclic, non-aromatic carbocyclic ring, heteroaryl and a monocyclic or bicyclic, non-aromatic heterocyclic ring; wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —O—C 1 -C 2 -alkyl-O—, —S(O) n R 5 , cyano, (C 1 -C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 10 )cycloalkyl, nitro, optionally substituted 4-7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5 , —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5  and —C(O)R 5 ;  
       wherein W is thiazolyl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5 , (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 -C 8 )alkylSO 2 R 5 , —(C 1 -C 8 )alkylSO 2 —(C 1 -C 8 )alkyl-R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —C(O)NR 5 R 5a , —CO 2 R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ;  
       wherein Z is selected from H, —N(R 5 ) 2 , —SR 5 , —OR 5 , —C(R 5 ) 3  and aryl; 
 wherein n is 0, 1 or 2;  
 wherein m is 0 or 1;  
 
       wherein R 1 , R 2 , R 3 , and R 4  are independently selected from H, —OR 5 , —OR 5a , halo, aryl, alkenyl, alkynyl, —NR 5   2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 4-10 membered heterocyclyl, —C(O)R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted arylalkyl, optionally substituted 4-10 membered heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; wherein R 1  and R 2  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; wherein R 2  and R 3  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; or wherein R 3  and R 4  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring;  
       wherein R 5  is independently selected from H, lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkyl-alkyl, and lower haloalkyl;  
       wherein R 5a  is alkylaminoalkyl;  
       wherein R 6  is selected from H, (C 1 -C 2 )alkyl, and a lone pair of electrons;  
       wherein a solid line with a dashed line (---) represents either a single or a double bond;  
       wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , or R 5  can optionally join with another R 1 , R 2 , R 3 , R 4 , or R 5  to form a 3-7 membered ring; and  
       wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, heterocyclyl, and alkoxy moiety of any R 1 , R 2 , R 3 , —R 4 , R 5 , Q and W is optionally substituted with one or more groups selected from halo, NH 2 , —OH, —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, C 1 -C 6 ) alkoxy, C 1 -C 6 )haloalkyl, di(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkyl, (C 1 -C 6 )hydroxyalkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl;  
       provided Z is not OH when Ar is aryl; further provided Q is not unsubstituted phenyl when W is thiazol-4-yl, when Z is H and when F is C—OCH 3 ; further provided Q is not 3,4-dimethoxyphenyl when W is thiazol-4-yl, when Z is H and when R 1 , R 2 , R 3  and R 4  are H; and further provided Q is not 3,4-dihydroxyphenyl when W is thiazol-2-yl, when Z is H and when R 1 , R 2 , R 3  and R 4  are H;  
       and pharmaceutically acceptable salts thereof.  
     
   
   
       45 . A method of treating stroke comprising administering an effective amount a compound of the following formula I:  
     
       
         
         
             
             
         
       
       wherein A is O, S or NH;  
       wherein D is CR 1  or N;  
       wherein E is CR 2  or N;  
       wherein F is CR 3  or N;  
       wherein G is CR 4  or N;  
       wherein J is selected from NR 6 , S, O, and CR 1 ;  
       wherein K is selected from NR 6 , S, O, and CR 2 ;  
       wherein L is selected from NR 6 , S, O, and CR 3 ;  
       wherein Q is selected from hydroxy, —N(R 5 ) 2 , —NR 5 C(O)R 5   1 —(C 1 -C 8 )alkyl-OR 5 , —(C 1 -C 8 )alkyl-S(O) n R 5 , —N(C 1 -C 8 -alkyl)-S(O) n R 5 , —NHS(O) n R 5 , aryl, a monocyclic or bicyclic, non-aromatic carbocyclic ring, heteroaryl and a monocyclic or bicyclic, non-aromatic heterocyclic ring; wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —O—C 1 -C 2 -alkyl-O—, —S(O) n R 5 , cyano, (C 1 -C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 10 )cycloalkyl, nitro, optionally substituted 4-7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5 , —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5  and —C(O)R 5 ;  
       wherein W is thiazolyl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5 , (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 -C 8 )alkylSO 2 R 5 , —(C 1 -C 8 )alkylSO 2 —(C 1 -C 8 )alkyl-R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —C(O)NR 5 R 5a , —CO 2 R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ;  
       wherein Z is selected from H, —N(R 5 ) 2 , —SR 5 , —OR 5 , —C(R 5 ) 3  and aryl; 
 wherein n is 0, 1 or 2;  
 wherein m is 0 or 1;  
 
       wherein R 1 , R 2 , R 3 , and R 4  are independently selected from H, —OR 5 , —OR 5a , halo, aryl, alkenyl, alkynyl, —NR 5   2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 4-10 membered heterocyclyl, —C(O)R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted arylalkyl, optionally substituted 4-10 membered heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; wherein R 1  and R 2  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; wherein R 2  and R 3  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; or wherein R 3  and R 4  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring;  
       wherein R 5  is independently selected from H, lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkyl-alkyl, and lower haloalkyl;  
       wherein R 5a  is alkylaminoalkyl;  
       wherein R 6  is selected from H, (C 1 -C 2 )alkyl, and a lone pair of electrons;  
       wherein a solid line with a dashed line (---) represents either a single or a double bond;  
       wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , or R 5  can optionally join with another R 1 , R 2 , R 3 , R 4 , or R 5  to form a 3-7 membered ring; and  
       wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, heterocyclyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , R 5 , Q and W is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, C 1 -C 6 )alkoxy, C 1 -C 6 )haloalkyl, di(C 1 -C 6 )alkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkyl, (C 1 -C 6 )hydroxyalkylamino, (C 1 -C 6 )alkylamino-(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl;  
       provided Z is not OH when Ar is aryl; further provided Q is not unsubstituted phenyl when W is thiazol-4-yl, when Z is H and when F is C—OCH 3 ; further provided Q is not 3,4-dimethoxyphenyl when W is thiazol-4-yl, when Z is H and when R 1 , R 2 , R 3  and R 4  are H; and further provided Q is not 3,4-dihydroxyphenyl when W is thiazol-2-yl, when Z is H and when R 1 , R 2 , R 3  and R 4  are H;  
       and pharmaceutically acceptable salts thereof.  
     
   
   
       46 . The method of  claim 41  wherein Q is selected from hydroxy, —N(R 5 ) 2 , —NR 5 C(O)R 5 , —(C 1 -C 8 )alkyl-OR 5 , —(C 1 -C 8 )alkyl-S(O) n R 5 , —N(C 1 -C 8 -alkyl)-S(O) n R 5 , —NHS(O) n R 5 , aryl, a monocyclic or bicyclic, non-aromatic carbocyclic ring, heteroaryl and a monocyclic or bicyclic, non-aromatic heterocyclic ring, 
 wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , (C 1 -C 8 )alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —S(O) n R 5 , cyano, (C 1 -C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 10 )cycloalkyl, nitro, optionally substituted 4-7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5 , —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5  and —C(O)R 5 ;    wherein W is a thiazol-4-yl or thiazol-2-yl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5 , (C 2 -C 8 ) alkenyl, (C 2 -C 8 ) alkynyl, —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 -C 8 )alkylSO 2 R 5 , —(C 1 -C 8 )alkylSO 2 —(C 1 -C 8 )alkyl-R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5  optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ;    wherein Z is selected from H, —N(R 5 ) 2 , —SR 5 , —OR 5 , —C(R 5 ) 3  and aryl;    wherein n is 0, 1 or 2;    wherein m is 0 or 1;    wherein R 1 , R 2 , R 3 , and R 4  are independently selected from H, —OR 5 , halo, aryl, alkenyl, alkynyl, —NR 5   2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5  (C 1 -C 8 )alkyl, (C 3 -C 10 ) cycloalkyl, nitro, cyano, optionally substituted 4-10 membered heterocyclyl, —C(O)R 5 , SO 2 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 —CO 2 R 5 , optionally substituted arylalkyl, optionally substituted 4-10 membered heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; wherein R 1  and R 2  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; wherein R 2  and R 3  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; or wherein R 3  and R 4  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring;    wherein R 5  is independently selected from H, lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted C 3 -C 6  cycloalkyl, optionally substituted C 3 -C 6  cycloalkyl-alkyl, and lower haloalkyl;    wherein R 6  is selected from H, (C 1 -C 2 )alkyl, and a lone pair of electrons;    wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , or R 5  can optionally join with another R 1 , R 2 , R 3 , R 4 , or R 5  to form a 3-7 membered ring; and    wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, heterocyclyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , R 5 , Q and W is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl.    
   
   
       47 . The method of  claim 42  wherein Q is selected from hydroxy, —N(R 5 ) 2 , —NR 5 C(O)R 5 , —(C 1 -C 8 )alkyl-OR 5 , —(C 1 -C 8 )alkyl-S(O) n R 5 , —N(C 1 -C 8 -alkyl)-S(O) n R 5 , —NHS(O) n R 5 , aryl, a monocyclic or bicyclic, non-aromatic carbocyclic ring, heteroaryl and a monocyclic or bicyclic, non-aromatic heterocyclic ring, 
 wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , (C 1 -C 8 )alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —S(O) n R 5 , cyano, (C 1 -C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 10 )cycloalkyl, nitro, optionally substituted 4-7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5   1 —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5 , —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5  and —C(O)R 5 ;    wherein W is a thiazol-4-yl or thiazol-2-yl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5 , (C 2 -C 8 ) alkenyl, (C 2 -C 8 )alkynyl, —N(R 5 ) 2 , (C 1 -C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 -C 8 )alkylSO 2 R 5 , —(C 1 -C 8 )alkylSO 2 —(C 1 -C 8 )alkyl-R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, nitro, cyano, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5  optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ;    wherein Z is selected from H, —N(R 5 ) 2 , —SR 5 , —OR 5 , —C(R 5 ) 3  and aryl;    wherein n is 0, 1 or 2;    wherein m is 0 or 1;    wherein R 1 , R 2 , R 3 , and R 4  are independently selected from H, —OR 5  halo, aryl, alkenyl, alkynyl, —NR 5   2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 ) cycloalkyl, nitro, cyano, optionally substituted 4-10 membered heterocyclyl, —C(O)R 5 , —SO 2 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted arylalkyl, optionally substituted 4-10 membered heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; wherein R 1  and R 2  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; wherein R 2  and R 3  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; or wherein R 3  and R 4  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring;    wherein R 5  is independently selected from H, lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted C 3 -C 6  cycloalkyl, optionally substituted C 3 -C 6  cycloalkyl-alkyl, and lower haloalkyl;    wherein R 6  is selected from H, (C 1 -C 2 )alkyl, and a lone pair of electrons;    wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , or R 5  can optionally join with another R 1 , R 2 , R 3 , R 4 , or R 5  to form a 3-7 membered ring; and    wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, heterocyclyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , R 5 , Q and W is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl.    
   
   
       48 . The method of  claim 44  wherein Q is selected from hydroxy, —N(R 5 ) 2 , —NR 5 C(O)R 5 , —(C 1 -C 8 )alkyl-OR 5 , —(C 1 -C 8 )alkyl-S(O) n R 5 , —N(C 1 -C 8 -alkyl)-S(O) n R 5 , —NHS(O) n R 5 , aryl, a monocyclic or bicyclic, non-aromatic carbocyclic ring, heteroaryl and a monocyclic or bicyclic, non-aromatic heterocyclic ring, 
 wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , (C 1 -C 8 )alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —S(O) n R 5 , cyano, (C 1 -C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 10 )cycloalkyl, nitro, optionally substituted 4-7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5 , —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5  and —C(O)R 5 ;    wherein W is a thiazol-4-yl or thiazol-2-yl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5 , (C 2 -C 8 ) alkenyl, (C 2 -C 8 ) alkynyl, —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 -C 8 )alkylSO 2 R 5 , —(C 1 -C 8 )alkylSO 2 —(C 1 -C 8 )alkyl-R 5  (C 1 -C 8 )alkyl, (C 3 -C 10 ) cycloalkyl, nitro, cyano, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5   1  optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ;    wherein Z is selected from H, —N(R 5 ) 2 , —SR 5 , —OR 5   1 —C(R 5 ) 3  and aryl;    wherein n is 0, 1 or 2;    wherein m is 0 or 1;    wherein R 1 , R 2 , R 3 , and R 4  are independently selected from H, —OR 5 , halo, aryl, alkenyl, alkynyl, —NR 5   2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 ) cycloalkyl, nitro, cyano, optionally substituted 4-10 membered heterocyclyl, —C(O)R 5 , SO 2 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted arylalkyl, optionally substituted 4-10 membered heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; wherein R 1  and R 2  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; wherein R 2  and R 3  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; or wherein R 3  and R 4  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring;    wherein R 5  is independently selected from H, lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted C 3 -C 6  cycloalkyl, optionally substituted C 3 -C 6  cycloalkyl-alkyl, and lower haloalkyl;    wherein R 6  is selected from H, (C 1 -C 2 )alkyl, and a lone pair of electrons;    wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , or R 5  can optionally join with another R 1 , R 2 , R 3 , R 4 , or R 5  to form a 3-7 membered ring; and    wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, heterocyclyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , R 5 , Q and W is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl.    
   
   
       49 . The method of  claim 45  wherein Q is selected from hydroxy, —N(R 5 ) 2 , —NR 5 C(O)R 5 , —(C 1 -C 8 )alkyl-OR 5 , —(C 1 -C 8 ) alkyl-S(O) n R 5 , —N(C 1 -C 8 -alkyl)-S(O) n R 5 , —NHS(O) n R 5 , aryl, a monocyclic or bicyclic, non-aromatic carbocyclic ring, heteroaryl and a monocyclic or bicyclic, non-aromatic heterocyclic ring, 
 wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, —OR 5 , —N(R 5 ) 2 , (C 1 -C 8 )alkyl-N(R 5 ) 2 , lower alkoxyalkyl, —S(O) n R 5 , cyano, (C 1 -C 8 )alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 10 )cycloalkyl, nitro, optionally substituted 4-7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 5 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , —CO 2 NR 5 R 5 , —SO 2 NHC(O)R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5 , —NR 5 CO 2 R 5  and —C(O)R 5 ;    wherein W is a thiazol-4-yl or thiazol-2-yl that is unsubstituted or substituted with one or more groups selected from halo, aryl, cycloalkyl, —OR 5 , (C 2 -C 8 ) alkenyl, (C 2 -C 8 ) alkynyl, —N(R 5 ) 2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —SO 2 NR 5 R 5 , —(C 1 -C 8 )alkylSO 2 R 5 , —(C 1 -C 8 )alkylSO 2 —(C 1 -C 8 )alkyl-R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 ) cycloalkyl, nitro, cyano, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, arylcarbonyl, —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ;    wherein Z is selected from H, —N(R 5 ) 2 , —SR 5 , —OR 5 , —C(R 5 ) 3  and aryl;    wherein n is 0, 1 or 2;    wherein m is 0 or 1;    wherein R 1 , R 2 , R 3 , and R 4  are independently selected from H, —OR 5 , halo, aryl, alkenyl, alkynyl, —NR 5   2 , —(C 1 -C 8 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 8 )alkyl, (C 3 -C 10 ) cycloalkyl, nitro, cyano, optionally substituted 4-10 membered heterocyclyl, —C(O)R 5 , —SO 2 R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted arylalkyl, optionally substituted 4-10 membered heterocyclylalkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; wherein R 1  and R 2  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; wherein R 2  and R 3  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring; or wherein R 3  and R 4  may be joined to form a 5-10 membered saturated or unsaturated carbocyclic or heterocyclic ring;    wherein R 5  is independently selected from H, lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted C 3 -C 6  cycloalkyl, optionally substituted C 3 -C 6  cycloalkyl-alkyl, and lower haloalkyl;    wherein R 6  is selected from H, (C 1 -C 2 )alkyl, and a lone pair of electrons;    wherein each alkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , or R 5  can optionally join with another R 1 , R 2 , R 3 , R 4 , or R 5  to form a 3-7 membered ring; and    wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, heterocyclyl, and alkoxy moiety of any R 1 , R 2 , R 3 , R 4 , R 5 , Q and W is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 6 )alkylamino, (C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino, phenyl, and heterocyclyl.    
   
   
       50 . The method of  claim 41  wherein A is O; wherein Ar is selected from phenyl, thienyl, pyrimidinyl, pyridyl and thiazolyl, wherein Ar is optionally substituted with one or more radicals selected from —OR 5 , chloro, fluoro, phenyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, —N(R 5 ) 2 , —(C 1 -C 6 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, nitro, cyano, optionally substituted 4-6 membered heterocyclyl, —C(O)R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted phenyl-C 1 -C 6 -alkyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 6 -alkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; 
 wherein Q is selected from —N(R 5 ) 2 , R 5 -carbonyl-HN—, R 5 -carbonyl-N(CH 3 )—, phenyl-O—(C 1 -C 2 )alkyl, R 5 SO 2 —(C 1 -C 2 )alkyl, —N(C 1 -C 2 -alkyl)-S(O) n R 5 , substituted or unsubstituted phenyl, benzodioxolyl and substituted or unsubstituted 5-6 membered heteroaryl;    wherein Z is selected from H, —N(R 5 ) 2 , —OR 5 , (C 1 -C 3 )alkyl and phenyl;    wherein R 5  is independently selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted 4-10 membered heterocyclyl-(C 1 -C 4 )alkyl, optionally substituted C 3 -C 6  cycloalkyl, optionally substituted C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl, and (C 1 -C 4 )haloalkyl; and    wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 ) alkyl, di(C 1 -C 4 )alkylamino, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl.    
   
   
       51 . The method of  claim 42  wherein A is O; wherein Ar is selected from phenyl, thienyl, pyrimidinyl, pyridyl and thiazolyl, wherein Ar is optionally substituted with one or more radicals selected from —OR 5 , chloro, fluoro, phenyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, —N(R 5 ) 2 , —(C 1 -C 6 )alkyl-N(R 5 ) 2 , —S(O) n-NR 5 R 5 , —S(O) n R 5 , (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, nitro, cyano, optionally substituted 4-6 membered heterocyclyl, —C(O)R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted phenyl-C 1 -C 6 -alkyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 6 -alkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; 
 wherein Q is selected from —N(R 5 ) 2 , R 5 -carbonyl-HN—, R 5 -carbonyl-N(CH 3 )—, phenyl-O— (C 1 -C 2 )alkyl, R 5 SO 2 —(C 1 -C 2 )alkyl, —N(C 1 -C 2 -alkyl)-S(O) n R 5 , substituted or unsubstituted phenyl, benzodioxolyl and substituted or unsubstituted 5-6 membered heteroaryl;    wherein Z is selected from H, —N(R 5 ) 2 , —OR 5 , (C 1 -C 3 )alkyl and phenyl;    wherein R 5  is independently selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted 4-10 membered heterocyclyl-(C 1 -C 4 )alkyl, optionally substituted C 3 -C 6  cycloalkyl, optionally substituted C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl, and (C 1 -C 4 )haloalkyl; and    wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 ) alkyl, di(C 1 -C 4 )alkylamino, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl.    
   
   
       52 . The method of  claim 44  wherein A is O; wherein Ar is selected from phenyl, thienyl, pyrimidinyl, pyridyl and thiazolyl, wherein Ar is optionally substituted with one or more radicals selected from —OR 5 , chloro, fluoro, phenyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, —N(R 5 ) 2 , —(C 1 -C 6 )alkyl-N(R 5 ) 2 , —S(O) n-NR 5 R 5 , —S(O) n R 5 , (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, nitro, cyano, optionally substituted 4-6 membered heterocyclyl, —C(O)R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted phenyl-C 1 -C 6 -alkyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 6 -alkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; 
 wherein Q is selected from —N(R 5 ) 2 , R 5 -carbonyl-HN—, R 5 -carbonyl-N(CH 3 )—, phenyl-O— (C 1 -C 2 )alkyl, R 5 SO 2 —(C 1 -C 2 )alkyl, —N(C 1 -C 2 -alkyl)-S(O) n R 5 , substituted or unsubstituted phenyl, benzodioxolyl and substituted or unsubstituted 5-6 membered heteroaryl;    wherein Z is selected from H, —N(R 5 ) 2 , —OR 5 , (C 1 -C 3 )alkyl and phenyl;    wherein R 5  is independently selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted 4-10 membered heterocyclyl-(C 1 -C 4 )alkyl, optionally substituted C 3 -C 6  cycloalkyl, optionally substituted C 3 -C 6  cycloalkyl-(C 1 -C 4 ) alkyl, and (C 1 -C 4 ) haloalkyl; and    wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 ) alkyl, di(C 1 -C 4 ) alkylamino, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl.    
   
   
       53 . The method of  claim 45  wherein A is O; wherein Ar is selected from phenyl, thienyl, pyrimidinyl, pyridyl and thiazolyl, wherein Ar is optionally substituted with one or more radicals selected from —OR 5 , chloro, fluoro, phenyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, —N(R 5 ) 2 , —(C 1 -C 6 )alkyl-N(R 5 ) 2 , —S(O) n —NR 5 R 5 , —S(O) n R 5 , (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, nitro, cyano, optionally substituted 4-6 membered heterocyclyl, —C(O)R 5 , —NR 5 SO 2 R 5 , —C(O)N(R 5 ) 2 , —CO 2 R 5 , optionally substituted phenyl-C 1 -C 6 -alkyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 6 -alkyl, —NR 5 C(O)N(R 5 ) 2 , —NR 5 C(O)R 5  and —NR 5 CO 2 R 5 ; 
 wherein Q is selected from —N(R 5 ) 2 , R 5 -carbonyl-HN—, R 5 -carbonyl-N(CH 3 )—, phenyl-O— (C 1 -C 2 )alkyl, R 5 SO 2 —(C 1 -C 2 )alkyl, —N(C 1 -C 2 -alkyl)-S(O) n R 5 , substituted or unsubstituted phenyl, benzodioxolyl and substituted or unsubstituted 5-6 membered heteroaryl;    wherein Z is selected from H, —N(R 5 ) 2 , —OR 5 , (C 1 -C 3 )alkyl and phenyl;    wherein R 5  is independently selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted 4-10 membered heterocyclyl-(C 1 -C 4 )alkyl, optionally substituted C 3 -C 6  cycloalkyl, optionally substituted C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl, and (C 1 -C 4 )haloalkyl; and    wherein each alkyl, aryl, heteroaryl, cycloalkyl, alkynyl, alkynyl, and alkoxy moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl.    
   
   
       54 . The method of  claim 50  wherein Ar is phenyl optionally substituted with one or more radicals selected from H, cyclopropylmethylamino, 3-hydroxypropylamino, 2-(piperidin-1-yl)ethylamino, (1-piperidylmethyl)amino, 2-(pyrrolidin-1-yl)ethylamino, 2-(morpholin-4-yl)ethylamino, 3-(piperidin-1-yl)propylamino, 3-(pyrrolidin-1-yl)propylamino, 3-(morpholin-4-yl)propylamino, N-methyl-N-(2-piperid-1-ylethyl)amino, N-methyl-N-(2-pyrrolidin-1-ylethyl)amino, N-methyl-N-(2-morpholin-4-ylethyl)amino, ((2S)-2-amino-3-phenylpropyl)amino, 4-methylpiperazin-1-ylamino, N-methyl-N-((tetrahydrofur-2-yl)methyl)amino, (4-piperidylmethyl)amino, amino, methylamino, (2-methylbutyl)amino, diethylamino, (diethylamino)ethylamino, aminomethyl, dimethylaminoethyl, isopropylaminomethyl, diethylaminomethyl, N-methyl-N-(isopropyl)aminomethyl, N-methyl-N-(diethylaminoethyl)aminomethyl, N-ethyl-N-(dimethylaminoethyl)aminomethyl, (1-hydroxymethyl-2-methylpropyl)amino, cyclopentylaminomethyl, 2-(dimethylamino)ethoxy, 3-(dimethylamino)propoxy, 2-(methylamino)ethoxy, ((2R)pyrrolidin-2-yl)methoxy, ((2R)-1-methylpyrrolidin-2-yl)methoxy, 2-(piperid-1-yl)ethoxy, 2-(piperazin-1-yl)ethoxy, 2-(morpholin-4-yl)ethoxy, hydroxy, benzyloxy, methoxy, chloro, fluoro, phenyl, aminosulfonyl, piperazinylsulfonyl, methylthio, methylsulfonyl, methyl, cyclopropyl, pyrrolidinyl, piperazinyl, piperidin-1-yl, morpholinyl, 4-methylpiperazin-1-yl, 3-aminopyrrolidin-1-yl, 3,5-dimethylpiperazin-1-yl, methylcarbonyl, phenylcarbonyl, piperidin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, morpholin-4-ylcarbonyl, trifluoromethyl, hydroxymethyl, hydroxyethyl, diethylaminocarbonyl, ethylaminocarbonyl, methoxycarbonyl, carboxy, optionally substituted benzyl, piperazinylmethyl, azetidin-1-ylmethyl, pyrrolidin-1-ylmethyl, 3-hydroxypyrrolidin-1-ylmethyl, 3-aminopyrrolidin-1-yl, 4-methylpiperazin-1-ylmethyl, 3-methylpiperazin-1-ylmethyl, 3,5-dimethylpiperazin-1-ylmethyl, 3-isopropylpiperazin-1-ylmethyl, 3,6-dihydropyridin-1-ylmethyl, 3-methylpiperidin-1-ylmethyl, 3,5-dimethylpiperidin-1-ylmethyl, 3-hydroxypiperidin-1-ylmethyl, 4-hydroxypiperidin-1-ylmethyl, piperidin-1-ylmethyl, 2,6-dimethylmorpholin-4-ylmethyl and morpholin-4-ylmethyl; wherein Q is selected from amino, 2-pyridylamino, 3-pyridylamino, 4-pyridylamino, phenylsulfonylamino, N-methyl-N-(3-fluorobenzylsulfonyl)amino, N-methyl-N-(2-pyridylsulfonyl)amino, N-methyl-N-(3-pyridylsulfonyl)amino, N-methyl-N-(4-pyridylsulfonyl)amino, N-methyl-N-(2-thienylsulfonyl)amino, N-methyl-N-(phenylsulfonyl)amino, N-methyl-N-(1-methylimidazol-4-ylsulfonyl)amino, 2-pyridylsulfonylmethyl, 3-pyridylsulfonylmethyl, 4-pyridylsulfonylmethyl, 2-thienylsulfonylmethyl, phenylsulfonylmethyl, 1-phenylsulfonyl-1-methylethyl, 2-furylmethylsulfonylmethyl, 3-trifluoromethylphenylmethyl-sulfonylmethyl, methylsulfonylmethyl, tert-butylsulfonylmethyl, 4-fluorophenyl-methylsulfonylmethyl, 4-chlorophenyl-methylsulfonylmethyl, 
 phenyl substituted with one or more substituents selected from H, hydroxyl, chloro, fluoro, methoxy, amino, aminomethyl, methylsulfonyl, methyl, cyano, trifluoromethyl, and pyrrolyl, unsubstituted pyridyl, and    pyridyl substituted with one or more substituents selected from chloro, fluoro, —NH 2 , —OH, —CO 2 H, methylamino, methyl, ethyl, diethyl-amino, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl and azetidinyl; substituted or unsubstituted pyridyl; and    wherein Z is selected from H, amino and phenyl.    
   
   
       55 . The method of  claim 51  wherein Ar is phenyl optionally substituted with one or more radicals selected from H, cyclopropylmethylamino, 3-hydroxypropylamino, 2-(piperidin-1-yl)ethylamino, (1-piperidylmethyl)amino, 2-(pyrrolidin-1-yl)ethylamino, 2-(morpholin-4-yl)ethylamino, 3-(piperidin-1-yl)propylamino, 3-(pyrrolidin-1-yl)propylamino, 3-(morpholin-4-yl)propylamino, N-methyl-N-(2-piperid-1-ylethyl)amino, N-methyl-N-(2-pyrrolidin-1-ylethyl)amino, N-methyl-N-(2-morpholin-4-ylethyl)amino, ((2S)-2-amino-3-phenylpropyl)amino, 4-methylpiperazin-1-ylamino, N-methyl-N-((tetrahydrofur-2-yl)methyl)amino, (4-piperidylmethyl)amino, amino, methylamino, (2-methylbutyl)amino, diethylamino, (diethylamino)ethylamino, aminomethyl, dimethylaminoethyl, isopropylaminomethyl, diethylaminomethyl, N-methyl-N-(isopropyl)aminomethyl, N-methyl-N-(diethylaminoethyl)aminomethyl, N-ethyl-N-(dimethylaminoethyl)aminomethyl, (1-hydroxymethyl-2-methylpropyl)amino, cyclopentylaminomethyl, 2-(dimethylamino)ethoxy, 3-(dimethylamino)propoxy, 2-(methylamino)ethoxy, ((2R)pyrrolidin-2-yl)methoxy, ((2R)-1-methylpyrrolidin-2-yl)methoxy, 2-(piperid-1-yl)ethoxy, 2-(piperazin-1-yl)ethoxy, 2-(morpholin-4-yl)ethoxy, hydroxy, benzyloxy, methoxy, chloro, fluoro, phenyl, aminosulfonyl, piperazinylsulfonyl, methylthio, methylsulfonyl, methyl, cyclopropyl, pyrrolidinyl, piperazinyl, piperidin-1-yl, morpholinyl, 4-methylpiperazin-1-yl, 3-aminopyrrolidin-1-yl, 3,5-dimethylpiperazin-1-yl, methylcarbonyl, phenylcarbonyl, piperidin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, morpholin-4-ylcarbonyl, trifluoromethyl, hydroxymethyl, hydroxyethyl, diethylaminocarbonyl, ethylaminocarbonyl, methoxycarbonyl, carboxy, optionally substituted benzyl, piperazinylmethyl, azetidin-1-ylmethyl, pyrrolidin-1-ylmethyl, 3-hydroxypyrrolidin-1-ylmethyl, 3-aminopyrrolidin-1-yl, 4-methylpiperazin-1-ylmethyl, 3-methylpiperazin-1-ylmethyl, 3,5-dimethylpiperazin-1-ylmethyl, 3-isopropylpiperazin-1-ylmethyl, 3,6-dihydropyridin-1-ylmethyl, 3-methylpiperidin-1-ylmethyl, 3,5-dimethylpiperidin-1-ylmethyl, 3-hydroxypiperidin-1-ylmethyl, 4-hydroxypiperidin-1-ylmethyl, piperidin-1-ylmethyl, 2,6-dimethylmorpholin-4-ylmethyl and morpholin-4-ylmethyl; wherein Q is selected from amino, 2-pyridylamino, 3-pyridylamino, 4-pyridylamino, phenylsulfonylamino, N-methyl-N-(3-fluorobenzylsulfonyl)amino, N-methyl-N-(2-pyridylsulfonyl)amino, N-methyl-N-(3-pyridylsulfonyl)amino, N-methyl-N-(4-pyridylsulfonyl)amino, N-methyl-N-(2-thienylsulfonyl)amino, N-methyl-N-(phenylsulfonyl)amino, N-methyl-N-(1-methylimidazol-4-ylsulfonyl)amino, 2-pyridylsulfonylmethyl, 3-pyridylsulfonylmethyl, 4-pyridylsulfonylmethyl, 2-thienylsulfonylmethyl, phenylsulfonylmethyl, 1-phenylsulfonyl-1-methylethyl, 2-furylmethylsulfonylmethyl, 3-trifluoromethylphenylmethyl-sulfonylmethyl, methylsulfonylmethyl, tert-butylsulfonylmethyl, 4-fluorophenyl-methylsulfonylmethyl, 4-chlorophenyl-methylsulfonylmethyl, 
 phenyl substituted with one or more substituents selected from H, hydroxyl, chloro, fluoro, methoxy, amino, aminomethyl, methylsulfonyl, methyl, cyano, trifluoromethyl, and pyrrolyl, unsubstituted pyridyl, and    pyridyl substituted with one or more substituents selected from chloro, fluoro, —NH 2 , —OH, —CO 2 H, methylamino, methyl, ethyl, diethyl-amino, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl and azetidinyl; substituted or unsubstituted pyridyl; and    wherein Z is selected from H, amino and phenyl.    
   
   
       56 . The method of  claim 52  wherein Ar is phenyl optionally substituted with one or more radicals selected from H, cyclopropylmethylamino, 3-hydroxypropylamino, 2-(piperidin-1-yl)ethylamino, (1-piperidylmethyl)amino, 2-(pyrrolidin-1-yl)ethylamino, 2-(morpholin-4-yl)ethylamino, 3-(piperidin-1-yl)propylamino, 3-(pyrrolidin-1-yl)propylamino, 3-(morpholin-4-yl)propylamino, N-methyl-N-(2-piperid-1-ylethyl)amino, N-methyl-N-(2-pyrrolidin-1-ylethyl)amino, N-methyl-N-(2-morpholin-4-ylethyl)amino, ((2S)-2-amino-3-phenylpropyl)amino, 4-methylpiperazin-1-ylamino, N-methyl-N-((tetrahydrofur-2-yl)methyl)amino, (4-piperidylmethyl)amino, amino, methylamino, (2-methylbutyl)amino, diethylamino, (diethylamino)ethylamino, aminomethyl, dimethylaminoethyl, isopropylaminomethyl, diethylaminomethyl, N-methyl-N-(isopropyl)aminomethyl, N-methyl-N-(diethylaminoethyl)aminomethyl, N-ethyl-N-(dimethylaminoethyl)aminomethyl, (1-hydroxymethyl-2-methylpropyl)amino, cyclopentylaminomethyl, 2-(dimethylamino)ethoxy, 3-(dimethylamino)propoxy, 2-(methylamino)ethoxy, ((2R)pyrrolidin-2-yl)methoxy, ((2R)-1-methylpyrrolidin-2-yl)methoxy, 2-(piperid-1-yl)ethoxy, 2-(piperazin-1-yl)ethoxy, 2-(morpholin-4-yl)ethoxy, hydroxy, benzyloxy, methoxy, chloro, fluoro, phenyl, aminosulfonyl, piperazinylsulfonyl, methylthio, methylsulfonyl, methyl, cyclopropyl, pyrrolidinyl, piperazinyl, piperidin-1-yl, morpholinyl, 4-methylpiperazin-1-yl, 3-aminopyrrolidin-1-yl, 3,5-dimethylpiperazin-1-yl, methylcarbonyl, phenylcarbonyl, piperidin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, morpholin-4-ylcarbonyl, trifluoromethyl, hydroxymethyl, hydroxyethyl, diethylaminocarbonyl, ethylaminocarbonyl, methoxycarbonyl, carboxy, optionally substituted benzyl, piperazinylmethyl, azetidin-1-ylmethyl, pyrrolidin-1-ylmethyl, 3-hydroxypyrrolidin-1-ylmethyl, 3-aminopyrrolidin-1-yl, 4-methylpiperazin-1-ylmethyl, 3-methylpiperazin-1-ylmethyl, 3,5-dimethylpiperazin-1-ylmethyl, 3-isopropylpiperazin-1-ylmethyl, 3,6-dihydropyridin-1-ylmethyl, 3-methylpiperidin-1-ylmethyl, 3,5-dimethylpiperidin-1-ylmethyl, 3-hydroxypiperidin-1-ylmethyl, 4-hydroxypiperidin-1-ylmethyl, piperidin-1-ylmethyl, 2,6-dimethylmorpholin-4-ylmethyl and morpholin-4-ylmethyl; wherein Q is selected from amino, 2-pyridylamino, 3-pyridylamino, 4-pyridylamino, phenylsulfonylamino, N-methyl-N-(3-fluorobenzylsulfonyl)amino, N-methyl-N-(2-pyridylsulfonyl)amino, N-methyl-N-(3-pyridylsulfonyl)amino, N-methyl-N-(4-pyridylsulfonyl)amino, N-methyl-N-(2-thienylsulfonyl)amino, N-methyl-N-(phenylsulfonyl)amino, N-methyl-N-(1-methylimidazol-4-ylsulfonyl)amino, 2-pyridylsulfonylmethyl, 3-pyridylsulfonylmethyl, 4-pyridylsulfonylmethyl, 2-thienylsulfonylmethyl, phenylsulfonylmethyl, 1-phenylsulfonyl-1-methylethyl, 2-furylmethylsulfonylmethyl, 3-trifluoromethylphenylmethyl-sulfonylmethyl, methylsulfonylmethyl, tert-butylsulfonylmethyl, 4-fluorophenyl-methylsulfonylmethyl, 4-chlorophenyl-methylsulfonylmethyl, 
 phenyl substituted with one or more substituents selected from H, hydroxyl, chloro, fluoro, methoxy, amino, aminomethyl, methylsulfonyl, methyl, cyano, trifluoromethyl, and pyrrolyl, unsubstituted pyridyl, and    pyridyl substituted with one or more substituents selected from chloro, fluoro, —NH 2 , —OH, —CO 2 H, methylamino, methyl, ethyl, diethyl-amino, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl and azetidinyl; substituted or unsubstituted pyridyl; and    wherein Z is selected from H, amino and phenyl.    
   
   
       57 . The method of  claim 53  wherein Ar is phenyl optionally substituted with one or more radicals selected from H, cyclopropylmethylamino, 3-hydroxypropylamino, 2-(piperidin-1-yl)ethylamino, (1-piperidylmethyl)amino, 2-(pyrrolidin-1-yl)ethylamino, 2-(morpholin-4-yl)ethylamino, 3-(piperidin-1-yl)propylamino, 3-(pyrrolidin-1-yl)propylamino, 3-(morpholin-4-yl)propylamino, N-methyl-N-(2-piperid-1-ylethyl)amino, N-methyl-N-(2-pyrrolidin-1-ylethyl)amino, N-methyl-N-(2-morpholin-4-ylethyl)amino, ((2S)-2-amino-3-phenylpropyl)amino, 4-methylpiperazin-1-ylamino, N-methyl-N-((tetrahydrofur-2-yl)methyl)amino, (4-piperidylmethyl)amino, amino, methylamino, (2-methylbutyl)amino, diethylamino, (diethylamino)ethylamino, aminomethyl, dimethylaminoethyl, isopropylaminomethyl, diethylaminomethyl, N-methyl-N-(isopropyl)aminomethyl, N-methyl-N-(diethylaminoethyl)aminomethyl, N-ethyl-N-(dimethylaminoethyl)aminomethyl, (1-hydroxymethyl-2-methylpropyl)amino, cyclopentylaminomethyl, 2-(dimethylamino)ethoxy, 3-(dimethylamino)propoxy, 2-(methylamino)ethoxy, ((2R)pyrrolidin-2-yl)methoxy, ((2R)-1-methylpyrrolidin-2-yl)methoxy, 2-(piperid-1-yl)ethoxy, 2-(piperazin-1-yl)ethoxy, 2-(morpholin-4-yl)ethoxy, hydroxy, benzyloxy, methoxy, chloro, fluoro, phenyl, aminosulfonyl, piperazinylsulfonyl, methylthio, methylsulfonyl, methyl, cyclopropyl, pyrrolidinyl, piperazinyl, piperidin-1-yl, morpholinyl, 4-methylpiperazin-1-yl, 3-aminopyrrolidin-1-yl, 3,5-dimethylpiperazin-1-yl, methylcarbonyl, phenylcarbonyl, piperidin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, morpholin-4-ylcarbonyl, trifluoromethyl, hydroxymethyl, hydroxyethyl, diethylaminocarbonyl, ethylaminocarbonyl, methoxycarbonyl, carboxy, optionally substituted benzyl, piperazinylmethyl, azetidin-1-ylmethyl, pyrrolidin-1-ylmethyl, 3-hydroxypyrrolidin-1-ylmethyl, 3-aminopyrrolidin-1-yl, 4-methylpiperazin-1-ylmethyl, 3-methylpiperazin-1-ylmethyl, 3,5-dimethylpiperazin-1-ylmethyl, 3-isopropylpiperazin-1-ylmethyl, 3,6-dihydropyridin-1-ylmethyl, 3-methylpiperidin-1-ylmethyl, 3,5-dimethylpiperidin-1-ylmethyl, 3-hydroxypiperidin-1-ylmethyl, 4-hydroxypiperidin-1-ylmethyl, piperidin-1-ylmethyl, 2,6-dimethylmorpholin-4-ylmethyl and morpholin-4-ylmethyl; wherein Q is selected from amino, 2-pyridylamino, 3-pyridylamino, 4-pyridylamino, phenylsulfonylamino, N-methyl-N-(3-fluorobenzylsulfonyl)amino, N-methyl-N-(2-pyridylsulfonyl)amino, N-methyl-N-(3-pyridylsulfonyl)amino, N-methyl-N-(4-pyridylsulfonyl)amino, N-methyl-N-(2-thienylsulfonyl)amino, N-methyl-N-(phenylsulfonyl)amino, N-methyl-N-(1-methylimidazol-4-ylsulfonyl)amino, 2-pyridylsulfonylmethyl, 3-pyridylsulfonylmethyl, 4-pyridylsulfonylmethyl, 2-thienylsulfonylmethyl, phenylsulfonylmethyl, 1-phenylsulfonyl-1-methylethyl, 2-furylmethylsulfonylmethyl, 3-trifluoromethylphenylmethyl-sulfonylmethyl, methylsulfonylmethyl, tert-butylsulfonylmethyl, 4-fluorophenyl-methylsulfonylmethyl, 4-chlorophenyl-methylsulfonylmethyl, 
 phenyl substituted with one or more substituents selected from H, hydroxyl, chloro, fluoro, methoxy, amino, aminomethyl, methylsulfonyl, methyl, cyano, trifluoromethyl, and pyrrolyl, unsubstituted pyridyl, and    pyridyl substituted with one or more substituents selected from chloro, fluoro, —NH 2 , —OH, —CO 2 H, methylamino, methyl, ethyl, diethyl-amino, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl and azetidinyl; substituted or unsubstituted pyridyl; and    wherein Z is selected from H, amino and phenyl.    
   
   
       58 . The method of  claim 41  wherein Q is selected from phenylsulfonylmethyl, N-methyl-N-(phenylsulfonyl)amino and 4-pyridyl.  
   
   
       59 . The method of  claim 42  wherein Q is selected from phenylsulfonylmethyl, N-methyl-N-(phenylsulfonyl)amino and 4-pyridyl.  
   
   
       60 . The method of  claim 44  wherein Q is selected from phenylsulfonylmethyl, N-methyl-N-(phenylsulfonyl)amino and 4-pyridyl.  
   
   
       61 . The method of  claim 45  wherein Q is selected from phenylsulfonylmethyl, N-methyl-N-(phenylsulfonyl)amino and 4-pyridyl.  
   
   
       62 . The method of  claim 41  wherein the compound has the following Formula II  
     
       
         
         
             
             
         
       
       wherein ring W′ is 4-thiazolyl or 2-thiazolyl;  
       wherein Z is selected from H, —N(R 11 ) 2 , —OR 11 , (C 1 -C 4 )alkyl and phenyl;  
       wherein R 8  is selected from —N(R 11 ) 2 , R 11 S(O) n —(C 1 -C 8 )alkyl, N—(C 1 -C 8 -alkyl)-N—[R 11 S(O) n ]amino, optionally substituted phenyl, benzodioxolyl, optionally substituted pyridyl, optionally substituted pyrazinyl, optionally substituted pyrimidinyl and optionally substituted pyridazinyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein n is 0, 1 or 2;  
       wherein R 10  is selected from H, halo, aryl, cycloalkyl, —OR 11 , (C 2 -C 8 ) alkenyl, (C 2 -C 8 ) alkynyl, —N(R 11 ) 2 , —(C 1 -C 8 )alkyl-N(R 11 ) 2 , —SO 2 NR 11 R 11 , (C 1 -C 8 )alkyl, cycloalkylalkyl, nitro, cyano, heteroaryl, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted phenylalkyl, optionally substituted heteroarylalkyl, —NR 11 C(O)N(R 11 ) 2 , —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ; and  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided Z is not OH; further provided R 8  is not unsubstituted 2-phenyl when Z is H, when ring W′ is thiazol-4-yl and when R 9  is 6-methoxy; further provided R 8  is not 2-phenyl or 2-[3,4-dimethoxyphenyl] when Z is H, ring W′ is thiazol-4-yl and when R 9  is H; and further provided R 8  is not 4-[3,4-dihydroxyphenyl] when Z is H, ring W′ is thiazol-2-yl and when R 9  is H.  
     
   
   
       63 . The method of  claim 42  wherein the compound has the following Formula II  
     
       
         
         
             
             
         
       
       wherein ring W′ is 4-thiazolyl or 2-thisazolyl;  
       wherein Z is selected from H, —N(R 11 ) 2 , —OR 11 , (C 1 -C 4 )alkyl and phenyl;  
       wherein R 8  is selected from —N(R 11 ) 2 , R 11 S(O) n —(C 1 -C 8 )alkyl, N—(C 1 -C 8 -alkyl)-N—[R 11 S(O) n ]amino, optionally substituted phenyl, benzodioxolyl, optionally substituted pyridyl, optionally substituted pyrazinyl, optionally substituted pyrimidinyl and optionally substituted pyridazinyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein n is 0, 1 or 2;  
       wherein R 10  is selected from H, halo, aryl, cycloalkyl, —OR 11 , (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, —N(R 11 ) 2 , —(C 1 -C 8 )alkyl-N(R 11 ) 2 , —SO 2 NR 11 R 11 , (C 1 -C 8 )alkyl, cycloalkylalkyl, nitro, cyano, heteroaryl, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted phenylalkyl, optionally substituted heteroarylalkyl, —NR 11 C(O)N(R 11 ) 2 , —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ; and  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided Z is not OH; further provided R 8  is not unsubstituted 2-phenyl when Z is H, when ring W′ is thiazol-4-yl and when R 9  is 6-methoxy; further provided R 8  is not 2-phenyl or 2-[3,4-dimethoxyphenyl] when Z is H, ring W′ is thiazol-4-yl and when R 9  is H; and further provided R 8  is not 4-[3,4-dihydroxyphenyl] when Z is H, ring WI is thiazol-2-yl and when R 9  is H.  
     
   
   
       64 . The method of  claim 44  wherein the compound has the following Formula II  
     
       
         
         
             
             
         
       
       wherein ring W′ is 4-thiazolyl or 2-thisazolyl;  
       wherein Z is selected from H, —N(R 11 ) 2 , —OR 11 , (C 1 -C 4 )alkyl and phenyl;  
       wherein R 8  is selected from —N(R 11 ) 2 , R 11 S(O) n —(C 1 -C 8 )alkyl, N—(C 1 -C 8 -alkyl)-N—[R 11 S(O) n ]amino, optionally substituted phenyl, benzodioxolyl, optionally substituted pyridyl, optionally substituted pyrazinyl, optionally substituted pyrimidinyl and optionally substituted pyridazinyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein n is 0, 1 or 2;  
       wherein R 10  is selected from H, halo, aryl, cycloalkyl, —OR 11 , (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, —N(R 11 ) 2 , —(C 1 -C 8 )alkyl-N(R 11 ) 2 , —SO 2 NR 11 R 11 , (C 1 -C 8 )alkyl, cycloalkylalkyl, nitro, cyano, heteroaryl, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted phenylalkyl, optionally substituted heteroarylalkyl, —NR 11 C(O)N(R 11 ) 2 , —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ; and  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided Z is not OH; further provided R 8  is not unsubstituted 2-phenyl when Z is H, when ring W′ is thiazol-4-yl and when R 9  is 6-methoxy; further provided R 8  is not 2-phenyl or 2-[3,4-dimethoxyphenyl] when Z is H, ring W′ is thiazol-4-yl and when R 9  is H; and further provided R 8  is not 4-[3,4-dihydroxyphenyl] when Z is H, ring W′ is thiazol-2-yl and when R 9  is H.  
     
   
   
       65 . The method of  claim 45  wherein the compound has the following Formula II  
     
       
         
         
             
             
         
       
       wherein ring W′ is 4-thiazolyl or 2-thisazolyl;  
       wherein Z is selected from H, —N(R 11 ) 2 , —OR 11 , (C 1 -C 4 )alkyl and phenyl;  
       wherein R 8  is selected from —N(R 11 ) 2 , R 11 S(O) n —(C 1 -C 8 )alkyl, N—(C 1 -C 8 -alkyl)-N—[R 11 S(O) n ]amino, optionally substituted phenyl, benzodioxolyl, optionally substituted pyridyl, optionally substituted pyrazinyl, optionally substituted pyrimidinyl and optionally substituted pyridazinyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein n is 0, 1 or 2;  
       wherein R 10  is selected from H, halo, aryl, cycloalkyl, —OR 11 , (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, —N(R 11 ) 2 , —(C 1 -C 8 )alkyl-N(R 11 ) 2 , —SO 2 NR 11 R 11 , (C 1 -C 8 )alkyl, cycloalkylalkyl, nitro, cyano, heteroaryl, optionally substituted 5-6 membered heterocyclyl, formyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted phenylalkyl, optionally substituted heteroarylalkyl, —NR 11 C(O)N(R 11 ) 2 , —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ; and  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided Z is not OH; further provided R 8  is not unsubstituted 2-phenyl when Z is H, when ring W′ is thiazol-4-yl and when R 9  is 6-methoxy;  
       further provided R 8  is not 2-phenyl or 2-[3,4-dimethoxyphenyl] when Z is H, ring W′ is thiazol-4-yl and when R 9  is H; and further provided R 8  is not 4-[3,4-dihydroxyphenyl] when Z is H, ring W′ is thiazol-2-yl and when R 9  is H.  
     
   
   
       66 . The method of  claim 41  wherein the compound is selected from: 
 3-[2-(6-methoxy-3-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    6-chloro-3-[2-(2-ethyl(4-pyridyl))(1,3-thiazol-4-yl)]hydroquinolin-2-one;    3-[2-(4-(1,2,3-thiadiazol-4-yl)phenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-[2-(2,3-dichlorophenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-benzenesulfonylmethyl-thiazol-4-yl)-7-trifluoromethyl-1H-quinolin-2-one;    3-[2-(4-chloro-benzenesulfonylmethyl)-thiazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one;    3-[2-(thienyl-2-sulfonylmethyl)-thiazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one;    7-piperidin-1-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(4-methyl-piperazin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4′-yl)-thiazol-4-yl]-1H-quinolin-2-one;    3-{2-[2-(3-hydroxy-propylamino)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    7-hydroxymethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(4-amino-phenyl)-thiazol-4-yl]-1H-quinolin-2-one;    3-{2-[2-(2-piperidin-1-yl-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(2-morpholin-4-yl-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(2-diethylamino-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(1-ethyl-pyrrolidin-3-yloxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    2-methylene-3-{2-[2-(5-methyl-tetrahydro-furan-2-ylmethoxy)-pyridin-4-yl]-thiazol-4-yl}-1,2-dihydro-quinoline;    3-{2-[2-(tetrahydro-furan-2-ylmethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-pyridin-4-yl}-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(2-chloro-pyridin-4-yl)-thiazol-4-yl]-1H-quinolin-2-one;    3-[2-(4-hydroxy-phenyl)-thiazol-4-yl]-1H-quinolin-2-one;    5-(piperidine-1-carbonyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(4-pyridin-4-yl-thiazol-2-yl)-1H-quinolin-2-one;    3-[4-(3-nitro-phenyl)-thiazol-2-yl]-1H-quinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-2(1H)-quinolinone;    3-[2-(3-pyridyl)-4-thiazolyl]-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-phenyl-2(1H)-quinolinone;    4-hydroxy-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-(1-piperidinyl)-2(1H)-quinolinone;    1,2-dihydro-2-oxo-3-[2-(4-pyridyl)-4-thiazolyl]-5-quinolinecarboxylic acid methyl ester;    3-[2-(3-pyridyl)-4-thiazolyl]-6,7-(methylenedioxyl)-2(1H)-quinolinone;    N,N-diethyl-1,2-dihydro-2-oxo-3-[2-(4-pyridyl)-4-thiazolyl]-5-quinolinecarboxamide;    3-[2-(2-ethyl-4-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-[2-(6-oxo-3-hydropyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    6-chloro-3-(2-(4-pyridyl)(1,3-thiazol-4-yl))hydroquinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-6,7-(methylenedioxyl)-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6,7-dimethoxy-2(1H)-quinolinone;    3-[2-(3-oyridyl)-4-thiazolyl]-4-amino-6,7-dimethoxy-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-chloro-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-(4-methyl-1-piperazinyl)-2(1H)-quinolinone;    3-[2-(2-ethyl(4-pyridyl))(1,3-thiazol-4-yl)]-6-fluorohydroquinolin-2-one;    6-fluoro-3-(2-(4-pyridyl)(1,3-thiazol-4-yl))hydroquinolin-2-one;    3-(2-(4-pyridyl)(1,3-thiazol-4-yl))-7-(trifluoromethyl)hydroquinolin-2-one;    3-[2-(2,6-dichlorophenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-(2,3-dihydrobenzo[b]furan-5-yl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-(2-(3-thienyl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-[2-(3,5-dichloro-4-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-{2-[(2-pyridylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-(2-{[(2-furylmethyl)sulfonyl]methyl}-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-{2-[({[3-(trifluoromethyl)phenyl]methyl}sulfonyl)-methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-[2-({[(4-fluorophenyl)methyl]sulfonyl}methyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-(2-thienyl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-(2-{[(4-chlorophenyl)sulfonyl]methyl}-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-{2-[(2-thienylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-{2-[(methylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-{2-[(phenylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-[2-(2-pyridylamino)-1,3-thiazol-4-yl]hydroquinolin-2-one hydrobromide;    3-[2-(3-pyridylamino)-1,3-thiazol-4-yl]hydroquinolin-2-one hydrobromide;    N-methyl-N-(4-(2-oxo-1,2-dihydro-3-quinolinyl)-1,3-thiazol-2-yl)benzenesulfonamide;    7-(Hydroxymethyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(3-Pyridinyl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    3-(2-(1,3-Benzodioxol-5-yl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    3-(2-Phenylthiomethyl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-Benzenesulfinylmethyl-thiazol-4-yl)-1H-quinolin-2-one;    N-Allyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    4-Bromo-N-methyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    3-Fluoro-N-methyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    N,1-Dimethyl-N-(4-(2-oxo-1,2-dihydro-3-quinolinyl)-1,3-thiazol-2-yl)-1H-imidazole-4-sulfonamide;    7-((4-Methyl-1-piperazinyl)carbonyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-piperidinylcarbonyl)-2(1H)-quinolinone    7-(Methoxy)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(1-Methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(1-Methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    7-(4-Morpholinylcarbonyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-hydroxy-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(Methoxy)-3-(2-(1-methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((2R)-2-(((1-Methylethyl)amino)methyl)-1-pyrrolidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((3S)-3-(1-Methylethyl)-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((4-Methyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3,5-Dimethyl-1-piperidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3-Methyl-1-piperidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3-methyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(3,6-Dihydro-1(2H)-pyridinylmethyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3,5-Dimethyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((2-(Diethylamino)ethyl)(methyl)amino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((Methyl(1-methylethyl)amino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-piperidinylmethyl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-pyrrolidinylmethyl)-2(1H)-quinolinone;    7-((Diethylamino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2,6-Dimethyl-4-morpholinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((4-Methyl-1-piperazinyl)carbonyl)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(3-Methyl-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-[(Isopropyl-methyl-amino)-methyl]-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    2-Oxo-3-(2-pyridin-4-yl-thiazol-4-yl)-1,2-dihydro-quinoline-7-carboxylic acid (2-dimethylamino-ethyl)-ethyl-amide;    7-(Piperidine-1-carbonyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-(2-Chloro-4-pyridinyl)-1,3-thiazol-4-yl)-7-(methoxy)-2(1H)-quinolinone;    Methyl 3-(2-(methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxylate;    3-(2-(Methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxylic acid;    N-Methyl-N-{4-[7-(4-methyl-piperazine-1-carbonyl)-2-oxo-1,2-dihydro-quinolin-3-yl]-thiazol-2-yl}-benzenesulfonamide;    3-[2-(Benzenesulfonyl-methyl-amino)-thiazol-4-yl]-2-oxo-1,2-dihydro-quinoline-7-carboxylic acid ethylamide;    N,N-Diethyl-3-(2-(methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxamide;    7-(Isopropylamino-methyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-Pyridin-4-yl-thiazol-4-yl)-7-pyrrolidin-1-ylmethyl-1H-quinolin-2-one;    7-Diethylaminomethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Azetidin-1-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Hydroxy-pyrrolidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-((3-(Dimethylamino)propyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2-(Dimethylamino)ethyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2-(4-Morpholinyl)ethyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(4-Hydroxy-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(2,6-Dimethyl-morpholin-4-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3,5-Dimethyl-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Morpholin-4-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Hydroxy-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-{[(2-Diethylamino-ethyl)-methyl-amino]-methyl}-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Cyclopentylaminomethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Methyl-piperazin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-{[(2-Dimethylamino-ethyl)-ethyl-amino]-methyl}-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(Isobutylamino-methyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one; and    7-[(1-Hydroxymethyl-2-methyl-propylamino)-methyl]-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one.    
   
   
       67 . The method of  claim 42  wherein the compound is selected from: 
 3-[2-(6-methoxy-3-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    6-chloro-3-[2-(2-ethyl(4-pyridyl))(1,3-thiazol-4-yl)]hydroquinolin-2-one;    3-[2-(4-(1,2,3-thiadiazol-4-yl)phenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-[2-(2,3-dichlorophenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-benzenesulfonylmethyl-thiazol-4-yl)-7-trifluoromethyl-1H-quinolin-2-one;    3-[2-(4-chloro-benzenesulfonylmethyl)-thiazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one;    3-[2-(thienyl-2-sulfonylmethyl)-thiazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one;    7-piperidin-1-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(4-methyl-piperazin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4′-yl)-thiazol-4-yl]-1H-quinolin-2-one;    3-{2-[2-(3-hydroxy-propylamino)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    7-hydroxymethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(4-amino-phenyl)-thiazol-4-yl]-1H-quinolin-2-one;    3-{2-[2-(2-piperidin-1-yl-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(2-morpholin-4-yl-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(2-diethylamino-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(1-ethyl-pyrrolidin-3-yloxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    2-methylene-3-{2-[2-(5-methyl-tetrahydro-furan-2-ylmethoxy)-pyridin-4-yl]-thiazol-4-yl}-1,2-dihydro-quinoline;    3-{2-[2-(tetrahydro-furan-2-ylmethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy)-pyridin-4-yl}-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(2-chloro-pyridin-4-yl)-thiazol-4-yl]-1H-quinolin-2-one;    3-[2-(4-hydroxy-phenyl)-thiazol-4-yl]-1H-quinolin-2-one;    5-(piperidine-1-carbonyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(4-pyridin-4-yl-thiazol-2-yl)-1H-quinolin-2-one;    3-[4-(3-nitro-phenyl)-thiazol-2-yl]-1H-quinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-2(1H)-quinolinone;    3-[2-(3-pyridyl)-4-thiazolyl]-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-phenyl-2(1H)-quinolinone;    4-hydroxy-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-(1-piperidinyl)-2(1H)-quinolinone;    1,2-dihydro-2-oxo-3-[2-(4-pyridyl)-4-thiazolyl]-5-quinolinecarboxylic acid methyl ester;    3-[2-(3-pyridyl)-4-thiazolyl]-6,7-(methylenedioxyl)-2(1H)-quinolinone;    N,N-diethyl-1,2-dihydro-2-oxo-3-(2-(4-pyridyl)-4-thiazolyl]-5-quinolinecarboxamide;    3-[2-(2-ethyl-4-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-[2-(6-oxo-3-hydropyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    6-chloro-3-(2-(4-pyridyl)(1,3-thiazol-4-yl))hydroquinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-6,7-(methylenedioxyl)-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6,7-dimethoxy-2(1H)-quinolinone;    3-[2-(3-oyridyl)-4-thiazolyl]-4-amino-6,7-dimethoxy-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-chloro-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-(4-methyl-1-piperazinyl)-2(1H)-quinolinone;    3-[2-(2-ethyl(4-pyridyl))(1,3-thiazol-4-yl)]-6-fluorohydroquinolin-2-one;    6-fluoro-3-(2-(4-pyridyl)(1,3-thiazol-4-yl))hydroquinolin-2-one;    3-(2-(4-pyridyl)(1,3-thiazol-4-yl))-7-(trifluoromethyl)hydroquinolin-2-one;    3-[2-(2,6-dichlorophenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-(2,3-dihydrobenzo[b]furan-5-yl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-(2-(3-thienyl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-[2-(3,5-dichloro-4-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-{2-[(2-pyridylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-(2-{[(2-furylmethyl)sulfonyl]methyl}-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-{2-[({[3-(trifluoromethyl)phenyl]methyl}sulfonyl)-methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-[2-({[(4-fluorophenyl)methyl]sulfonyl}methyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-(2-thienyl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-(2-{[(4-chlorophenyl)sulfonyl]methyl}-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-{2-[(2-thienylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-{2-[(methylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-{2-[(phenylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-[2-(2-pyridylamino)-1,3-thiazol-4-yl]hydroquinolin-2-one hydrobromide;    3-[2-(3-pyridylamino)-1,3-thiazol-4-yl]hydroquinolin-2-one hydrobromide;    N-methyl-N-(4-(2-oxo-1,2-dihydro-3-quinolinyl)-1,3-thiazol-2-yl)benzenesulfonamide;    7-(Hydroxymethyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(3-Pyridinyl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    3-(2-(1,3-Benzodioxol-5-yl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    3-(2-Phenylthiomethyl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-Benzenesulfinylmethyl-thiazol-4-yl)-1H-quinolin-2-one;    N-Allyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    4-Bromo-N-methyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    3-Fluoro-N-methyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    N,1-Dimethyl-N-(4-(2-oxo-1,2-dihydro-3-quinolinyl)-1,3-thiazol-2-yl)-1H-imidazole-4-sulfonamide;    7-((4-Methyl-1-piperazinyl)carbonyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-piperidinylcarbonyl)-2(1H)-quinolinone    7-(Methoxy)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(1-Methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(1-Methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    7-(4-Morpholinylcarbonyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-hydroxy-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(Methoxy)-3-(2-(1-methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((2R)-2-(((1-Methylethyl)amino)methyl)-1-pyrrolidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((3S)-3-(1-Methylethyl)-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((4-Methyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3,5-Dimethyl-1-piperidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3-Methyl-1-piperidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3-methyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(3,6-Dihydro-1(2H)-pyridinylmethyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3,5-Dimethyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((2-(Diethylamino)ethyl)(methyl)amino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((Methyl(1-methylethyl)amino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-piperidinylmethyl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-pyrrolidinylmethyl)-2(1H)-quinolinone;    7-((Diethylamino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2,6-Dimethyl-4-morpholinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((4-Methyl-1-piperazinyl)carbonyl)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(3-Methyl-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-[(Isopropyl-methyl-amino)-methyl]-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    2-Oxo-3-(2-pyridin-4-yl-thiazol-4-yl)-1,2-dihydro-quinoline-7-carboxylic acid (2-dimethylamino-ethyl)-ethyl-amide;    7-(Piperidine-1-carbonyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-(2-Chloro-4-pyridinyl)-1,3-thiazol-4-yl)-7-(methoxy)-2(1H)-quinolinone;    Methyl 3-(2-(methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxylate;    3-(2-(Methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxylic acid;    N-Methyl-N-{4-[7-(4-methyl-piperazine-1-carbonyl)-2-oxo-1,2-dihydro-quinolin-3-yl]-thiazol-2-yl}-benzenesulfonamide;    3-[2-(Benzenesulfonyl-methyl-amino)-thiazol-4-yl]-2-oxo-1,2-dihydro-quinoline-7-carboxylic acid ethylamide;    N,N-Diethyl-3-(2-(methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxamide;    7-(Isopropylamino-methyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-Pyridin-4-yl-thiazol-4-yl)-7-pyrrolidin-1-ylmethyl-1H-quinolin-2-one;    7-Diethylaminomethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Azetidin-1-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Hydroxy-pyrrolidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-((3-(Dimethylamino)propyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2-(Dimethylamino)ethyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2-(4-Morpholinyl)ethyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(4-Hydroxy-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(2,6-Dimethyl-morpholin-4-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3,5-Dimethyl-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Morpholin-4-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Hydroxy-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-{[(2-Diethylamino-ethyl)-methyl-amino]-methyl}-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Cyclopentylaminomethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Methyl-piperazin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-{[(2-Dimethylamino-ethyl)-ethyl-amino]-methyl}-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(Isobutylamino-methyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one; and    7-[(1-Hydroxymethyl-2-methyl-propylamino)-methyl]-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one.    
   
   
       68 . The method of  claim 44  wherein the compound is selected from: 
 3-[2-(6-methoxy-3-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    6-chloro-3-[2-(2-ethyl(4-pyridyl))(1,3-thiazol-4-yl)]hydroquinolin-2-one;    3-[2-(4-(1,2,3-thiadiazol-4-yl)phenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-[2-(2,3-dichlorophenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-benzenesulfonylmethyl-thiazol-4-yl)-7-trifluoromethyl-1H-quinolin-2-one;    3-[2-(4-chloro-benzenesulfonylmethyl)-thiazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one;    3-[2-(thienyl-2-sulfonylmethyl)-thiazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one;    7-piperidin-1-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(4-methyl-piperazin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4′-yl)-thiazol-4-yl]-1H-quinolin-2-one;    3-{2-[2-(3-hydroxy-propylamino)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    7-hydroxymethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(4-amino-phenyl)-thiazol-4-yl]-1H-quinolin-2-one;    3-{2-[2-(2-piperidin-1-yl-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(2-morpholin-4-yl-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(2-diethylamino-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(1-ethyl-pyrrolidin-3-yloxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    2-methylene-3-{2-[2-(5-methyl-tetrahydro-furan-2-ylmethoxy)-pyridin-4-yl]-thiazol-4-yl}-1,2-dihydro-quinoline;    3-{2-[2-(tetrahydro-furan-2-ylmethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-pyridin-4-yl}-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(2-chloro-pyridin-4-yl)-thiazol-4-yl]-1H-quinolin-2-one;    3-[2-(4-hydroxy-phenyl)-thiazol-4-yl]-1H-quinolin-2-one;    5-(piperidine-1-carbonyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(4-pyridin-4-yl-thiazol-2-yl)-1H-quinolin-2-one;    3-[4-(3-nitro-phenyl)-thiazol-2-yl]-1H-quinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-2(1H)-quinolinone;    3-[2-(3-pyridyl)-4-thiazolyl]-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-phenyl-2(1H)-quinolinone;    4-hydroxy-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-(1-piperidinyl)-2(1H)-quinolinone;    1,2-dihydro-2-oxo-3-[2-(4-pyridyl)-4-thiazolyl]-5-quinolinecarboxylic acid methyl ester;    3-[2-(3-pyridyl)-4-thiazolyl]-6,7-(methylenedioxyl)-2(1H)-quinolinone;    N,N-diethyl-1,2-dihydro-2-oxo-3-[2-(4-pyridyl)-4-thiazolyl]-5-quinolinecarboxamide;    3-[2-(2-ethyl-4-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-[2-(6-oxo-3-hydropyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    6-chloro-3-(2-(4-pyridyl)(1,3-thiazol-4-yl))hydroquinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-6,7-(methylenedioxyl)-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6,7-dimethoxy-2(1H)-quinolinone;    3-[2-(3-oyridyl)-4-thiazolyl]-4-amino-6,7-dimethoxy-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-chloro-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-(4-methyl-1-piperazinyl)-2(1H)-quinolinone;    3-[2-(2-ethyl(4-pyridyl))(1,3-thiazol-4-yl)]-6-fluorohydroquinolin-2-one;    6-fluoro-3-(2-(4-pyridyl)(1,3-thiazol-4-yl))hydroquinolin-2-one;    3-(2-(4-pyridyl)(1,3-thiazol-4-yl))-7-(trifluoromethyl)hydroquinolin-2-one;    3-[2-(2,6-dichlorophenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-(2,3-dihydrobenzo[b]furan-5-yl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-(2-(3-thienyl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-[2-(3,5-dichloro-4-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-{2-[(2-pyridylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-(2-{[(2-furylmethyl)sulfonyl]methyl}-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-{2-[({[3-(trifluoromethyl)phenyl]methyl}sulfonyl)-methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-[2-({[(4-fluorophenyl)methyl]sulfonyl}methyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-(2-thienyl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-(2-{[(4-chlorophenyl)sulfonyl]methyl}-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-{2-[(2-thienylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-{2-[(methylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-{2-[(phenylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-[2-(2-pyridylamino)-1,3-thiazol-4-yl]hydroquinolin-2-one hydrobromide;    3-[2-(3-pyridylamino)-1,3-thiazol-4-yl]hydroquinolin-2-one hydrobromide;    N-methyl-N-(4-(2-oxo-1,2-dihydro-3-quinolinyl)-1,3-thiazol-2-yl)benzenesulfonamide;    7-(Hydroxymethyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(3-Pyridinyl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    3-(2-(1,3-Benzodioxol-5-yl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    3-(2-Phenylthiomethyl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-Benzenesulfinylmethyl-thiazol-4-yl)-1H-quinolin-2-one;    N-Allyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    4-Bromo-N-methyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    3-Fluoro-N-methyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    N,1-Dimethyl-N-(4-(2-oxo-1,2-dihydro-3-quinolinyl)-1,3-thiazol-2-yl)-1H-imidazole-4-sulfonamide;    7-((4-Methyl-1-piperazinyl)carbonyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-piperidinylcarbonyl)-2(1H)-quinolinone    7-(Methoxy)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(1-Methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(1-Methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    7-(4-Morpholinylcarbonyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-hydroxy-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(Methoxy)-3-(2-(1-methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((2R)-2-(((1-Methylethyl)amino)methyl)-1-pyrrolidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((3S)-3-(1-Methylethyl)-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((4-Methyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3,5-Dimethyl-1-piperidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3-Methyl-1-piperidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3-methyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(3,6-Dihydro-1(2H)-pyridinylmethyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3,5-Dimethyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((2-(Diethylamino)ethyl)(methyl)amino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((Methyl(1-methylethyl)amino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-piperidinylmethyl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-pyrrolidinylmethyl)-2(1H)-quinolinone;    7-((Diethylamino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2,6-Dimethyl-4-morpholinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((4-Methyl-1-piperazinyl)carbonyl)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(3-Methyl-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-[(Isopropyl-methyl-amino)-methyl]-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    2-Oxo-3-(2-pyridin-4-yl-thiazol-4-yl)-1,2-dihydro-quinoline-7-carboxylic acid (2-dimethylamino-ethyl)-ethyl-amide;    7-(Piperidine-1-carbonyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-(2-Chloro-4-pyridinyl)-1,3-thiazol-4-yl)-7-(methoxy)-2(1H)-quinolinone;    Methyl 3-(2-(methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxylate;    3-(2-(Methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxylic acid;    N-Methyl-N-{4-[7-(4-methyl-piperazine-1-carbonyl)-2-oxo-1,2-dihydro-quinolin-3-yl]-thiazol-2-yl}-benzenesulfonamide;    3-[2-(Benzenesulfonyl-methyl-amino)-thiazol-4-yl]-2-oxo-1,2-dihydro-quinoline-7-carboxylic acid ethylamide;    N,N-Diethyl-3-(2-(methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxamide;    7-(Isopropylamino-methyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-Pyridin-4-yl-thiazol-4-yl)-7-pyrrolidin-1-ylmethyl-1H-quinolin-2-one;    7-Diethylaminomethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Azetidin-1-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Hydroxy-pyrrolidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-((3-(Dimethylamino)propyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2-(Dimethylamino)ethyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2-(4-Morpholinyl)ethyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(4-Hydroxy-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(2,6-Dimethyl-morpholin-4-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3,5-Dimethyl-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Morpholin-4-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Hydroxy-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-{[(2-Diethylamino-ethyl)-methyl-amino]-methyl}-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Cyclopentylaminomethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Methyl-piperazin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-{[(2-Dimethylamino-ethyl)-ethyl-amino]-methyl}-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(Isobutylamino-methyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one; and    7-[(1-Hydroxymethyl-2-methyl-propylamino)-methyl]-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one.    
   
   
       69 . The method of  claim 45  wherein the compound is selected from: 
 3-[2-(6-methoxy-3-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    6-chloro-3-[2-(2-ethyl(4-pyridyl))(1,3-thiazol-4-yl)]hydroquinolin-2-one;    3-[2-(4-(1,2,3-thiadiazol-4-yl)phenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-[2-(2,3-dichlorophenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-benzenesulfonylmethyl-thiazol-4-yl)-7-trifluoromethyl-1H-quinolin-2-one;    3-[2-(4-chloro-benzenesulfonylmethyl)-thiazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one;    3-[2-(thienyl-2-sulfonylmethyl)-thiazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one;    7-piperidin-1-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(4-methyl-piperazin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4′-yl)-thiazol-4-yl]-1H-quinolin-2-one;    3-{2-[2-(3-hydroxy-propylamino)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    7-hydroxymethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(4-amino-phenyl)-thiazol-4-yl]-1H-quinolin-2-one;    3-{2-[2-(2-piperidin-1-yl-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(2-morpholin-4-yl-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(2-diethylamino-ethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-{2-[2-(1-ethyl-pyrrolidin-3-yloxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    2-methylene-3-{2-[2-(5-methyl-tetrahydro-furan-2-ylmethoxy)-pyridin-4-yl]-thiazol-4-yl}-1,2-dihydro-quinoline;    3-{2-[2-(tetrahydro-furan-2-ylmethoxy)-pyridin-4-yl]-thiazol-4-yl}-1H-quinolin-2-one;    3-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-pyridin-4-yl}-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(2-chloro-pyridin-4-yl)-thiazol-4-yl]-1H-quinolin-2-one;    3-[2-(4-hydroxy-phenyl)-thiazol-4-yl]-1H-quinolin-2-one;    5-(piperidine-1-carbonyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(4-pyridin-4-yl-thiazol-2-yl)-1H-quinolin-2-one;    3-[4-(3-nitro-phenyl)-thiazol-2-yl]-1H-quinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-2(1H)-quinolinone;    3-[2-(3-pyridyl)-4-thiazolyl]-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-phenyl-2(1H)-quinolinone;    4-hydroxy-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-(1-piperidinyl)-2(1H)-quinolinone;    1,2-dihydro-2-oxo-3-[2-(4-pyridyl)-4-thiazolyl]-5-quinolinecarboxylic acid methyl ester;    3-[2-(3-pyridyl)-4-thiazolyl]-6,7-(methylenedioxyl)-2(1H)-quinolinone;    N,N-diethyl-1,2-dihydro-2-oxo-3-[2-(4-pyridyl)-4-thiazolyl]-5-quinolinecarboxamide;    3-[2-(2-ethyl-4-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-[2-(6-oxo-3-hydropyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    6-chloro-3-(2-(4-pyridyl)(1,3-thiazol-4-yl))hydroquinolin-2-one;    3-[2-(4-pyridyl)-4-thiazolyl]-6,7-(methylenedioxyl)-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6,7-dimethoxy-2(1H)-quinolinone;    3-[2-(3-oyridyl)-4-thiazolyl]-4-amino-6,7-dimethoxy-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-chloro-2(1H)-quinolinone;    3-[2-(4-pyridyl)-4-thiazolyl]-4-amino-6-(4-methyl-1-piperazinyl)-2(1H)-quinolinone;    3-[2-(2-ethyl(4-pyridyl))(1,3-thiazol-4-yl)]-6-fluorohydroquinolin-2-one;    6-fluoro-3-(2-(4-pyridyl)(1,3-thiazol-4-yl))hydroquinolin-2-one;    3-(2-(4-pyridyl)(1,3-thiazol-4-yl))-7-(trifluoromethyl)hydroquinolin-2-one;    3-[2-(2,6-dichlorophenyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-(2,3-dihydrobenzo[b]furan-5-yl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-(2-(3-thienyl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-[2-(3,5-dichloro-4-pyridyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-{2-[(2-pyridylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-(2-{[(2-furylmethyl)sulfonyl]methyl}-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-{2-[({[3-(trifluoromethyl)phenyl]methyl}sulfonyl)-methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-[2-({[(4-fluorophenyl)methyl]sulfonyl}methyl)-1,3-thiazol-4-yl]hydroquinolin-2-one;    3-(2-(2-thienyl)-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-(2-{[(4-chlorophenyl)sulfonyl]methyl}-1,3-thiazol-4-yl)hydroquinolin-2-one;    3-{2-[(2-thienylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-{2-[(methylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-{2-[(phenylsulfonyl)methyl]-1,3-thiazol-4-yl}hydroquinolin-2-one;    3-[2-(2-pyridylamino)-1,3-thiazol-4-yl]hydroquinolin-2-one hydrobromide;    3-[2-(3-pyridylamino)-1,3-thiazol-4-yl]hydroquinolin-2-one hydrobromide;    N-methyl-N-(4-(2-oxo-1,2-dihydro-3-quinolinyl)-1,3-thiazol-2-yl)benzenesulfonamide;    7-(Hydroxymethyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(3-Pyridinyl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    3-(2-(1,3-Benzodioxol-5-yl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    3-(2-Phenylthiomethyl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-Benzenesulfinylmethyl-thiazol-4-yl)-1H-quinolin-2-one;    N-Allyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    4-Bromo-N-methyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    3-Fluoro-N-methyl-N-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-yl]-benzenesulfonamide;    N,1-Dimethyl-N-(4-(2-oxo-1,2-dihydro-3-quinolinyl)-1,3-thiazol-2-yl)-1H-imidazole-4-sulfonamide;    7-((4-Methyl-1-piperazinyl)carbonyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-piperidinylcarbonyl)-2(1H)-quinolinone    7-(Methoxy)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(1-Methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-(1-Methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-7-(trifluoromethyl)-2(1H)-quinolinone;    7-(4-Morpholinylcarbonyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-hydroxy-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(Methoxy)-3-(2-(1-methyl-1-(phenylsulfonyl)ethyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((2R)-2-(((1-Methylethyl)amino)methyl)-1-pyrrolidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((3S)-3-(1-Methylethyl)-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((4-Methyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3,5-Dimethyl-1-piperidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3-Methyl-1-piperidinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3-methyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(3,6-Dihydro-1(2H)-pyridinylmethyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((3,5-Dimethyl-1-piperazinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(((2-(Diethylamino)ethyl)(methyl)amino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((Methyl(1-methylethyl)amino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-piperidinylmethyl)-2(1H)-quinolinone;    3-(2-((Phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-7-(1-pyrrolidinylmethyl)-2(1H)-quinolinone;    7-((Diethylamino)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2,6-Dimethyl-4-morpholinyl)methyl)-3-(2-((phenylsulfonyl)methyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((4-Methyl-1-piperazinyl)carbonyl)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(3-Methyl-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-[(Isopropyl-methyl-amino)-methyl]-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    2-Oxo-3-(2-pyridin-4-yl-thiazol-4-yl)-1,2-dihydro-quinoline-7-carboxylic acid (2-dimethylamino-ethyl)-ethyl-amide;    7-(Piperidine-1-carbonyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-(2-Chloro-4-pyridinyl)-1,3-thiazol-4-yl)-7-(methoxy)-2(1H)-quinolinone;    Methyl 3-(2-(methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxylate;    3-(2-(Methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxylic acid;    N-Methyl-N-{4-[7-(4-methyl-piperazine-1-carbonyl)-2-oxo-1,2-dihydro-quinolin-3-yl]-thiazol-2-yl}-benzenesulfonamide;    3-[2-(Benzenesulfonyl-methyl-amino)-thiazol-4-yl]-2-oxo-1,2-dihydro-quinoline-7-carboxylic acid ethylamide;    N,N-Diethyl-3-(2-(methyl(phenylsulfonyl)amino)-1,3-thiazol-4-yl)-2-oxo-1,2-dihydro-7-quinolinecarboxamide;    7-(Isopropylamino-methyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    3-(2-Pyridin-4-yl-thiazol-4-yl)-7-pyrrolidin-1-ylmethyl-1H-quinolin-2-one;    7-Diethylaminomethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Azetidin-1-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Hydroxy-pyrrolidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-((3-(Dimethylamino)propyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2-(Dimethylamino)ethyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-((2-(4-Morpholinyl)ethyl)oxy)-3-(2-(4-pyridinyl)-1,3-thiazol-4-yl)-2(1H)-quinolinone;    7-(4-Hydroxy-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(2,6-Dimethyl-morpholin-4-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3,5-Dimethyl-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Morpholin-4-ylmethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Hydroxy-piperidin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-{[(2-Diethylamino-ethyl)-methyl-amino]-methyl}-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-Cyclopentylaminomethyl-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(3-Methyl-piperazin-1-ylmethyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-{[(2-Dimethylamino-ethyl)-ethyl-amino]-methyl}-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one;    7-(Isobutylamino-methyl)-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one; and    7-[(1-Hydroxymethyl-2-methyl-propylamino)-methyl]-3-(2-pyridin-4-yl-thiazol-4-yl)-1H-quinolin-2-one.    
   
   
       70 . The method of  claim 41  wherein the compound has the following Formula III:  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino, hydroxy and phenyl;  
       wherein R 8  is selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; wherein R 8  is unsubstituted or substituted with one or more substituents selected from chloro, fluoro, —NH 2 , —OH, —CO 2 H, (C 1 -C 2 )alkylamino, (C 1 -C 2 )alkyl, di(C 1 -C 2 )alkylamino, (C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, hydroxy-(C 1 -C 2 )alkylamino, 5-6-membered heterocyclyloxy, 5-6-membered heterocyclyl-(C 1 -C 2 )alkoxy, [(C 1 -C 2 )alkoxy] 1-3 , phenyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl and azetidinyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 1 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided R 8  is attached at thiazole ring position 2 or 4, and the quinolinone ring is attached at the other of thiazole ring positions 2 or 4.  
     
   
   
       71 . The method of  claim 42  wherein the compound has the following Formula III:  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino, hydroxy and phenyl;  
       wherein R 8  is selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; wherein R 8  is unsubstituted or substituted with one or more substituents selected from chloro, fluoro, —NH 2 , —OH, —CO 2 H, (C 1 -C 2 )alkylamino, (C 1 -C 2 )alkyl, di(C 1 -C 2 )alkylamino, (C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, hydroxy-(C 1 -C 2 )alkylamino, 5-6-membered heterocyclyloxy, 5-6-membered heterocyclyl-(C 1 -C 2 ) alkoxy, [(C 1 -C 2 )alkoxy] 1-3 , phenyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl and azetidinyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided R 8  is attached at thiazole ring position 2 or 4, and the quinolinone ring is attached at the other of thiazole ring positions 2 or 4.  
     
   
   
       72 . The method of  claim 44  wherein the compound has the following Formula III:  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino, hydroxy and phenyl;  
       wherein R 8  is selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; wherein R 8  is unsubstituted or substituted with one or more substituents selected from chloro, fluoro, —NH 2 , —OH, —CO 2 H, (C 1 -C 2 )alkylamino, (C 1 -C 2 )alkyl, di(C 1 -C 2 )alkylamino, (C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, hydroxy-(C 1 -C 2 )alkylamino, 5-6-membered heterocyclyloxy, 5-6-membered heterocyclyl-(C 1 -C 2 )alkoxy, [(C 1 -C 2 )alkoxy] 1-3 , phenyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl and azetidinyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided R 8  is attached at thiazole ring position 2 or 4, and the quinolinone ring is attached at the other of thiazole ring positions 2 or 4.  
     
   
   
       73 . The method of  claim 45  wherein the compound has the following Formula III:  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino, hydroxy and phenyl;  
       wherein R 8  is selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; wherein R 8  is unsubstituted or substituted with one or more substituents selected from chloro, fluoro, —NH 2 , —OH, —CO 2 H, (C 1 -C 2 )alkylamino, (C 1 -C 2 )alkyl, di(C 1 -C 2 )alkylamino, (C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, hydroxy-(C 1 -C 2 )alkylamino, 5-6-membered heterocyclyloxy, 5-6-membered heterocyclyl-(C 1 -C 2 )alkoxy, [(C 1 -C 2 )alkoxy] 1-3 , phenyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl and azetidinyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 ,  13  S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided R 8  is attached at thiazole ring position 2 or 4, and the quinolinone ring is attached at the other of thiazole ring positions 2 or 4.  
     
   
   
       74 . The method of  claim 41  wherein the compound has the following Formula IV  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino and phenyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein R 12  is one or more substituents selected from H, hydroxyl, halo, aryl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )alkenyl, —OR 11 , —O—C 1-2 -alkyl-O—, —N(R 11 ) 2 , —(C 1 -C 4 ) alkyl-N(R 11 ) 2 , lower alkoxyalkyl, R 11 —SO 2 —, (C 1 -C 4 )alkyl, cyano, nitro, lower cyanoalkyl, lower haloalkyl, lower hydroxyalkyl, lower aminoalkyl, lower alkylaminoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 6 )cycloalkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 11 R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , —CO 2 NR 11 R 11 , —SO 2 NHC(O)R 11 , optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted heterocyclyl-(C 1 -C 4 )alkyl, —NR 11 C(O)N(R 11 ) 2 , —NR 11 C(O)R 11 , —NR 11 CO 2 R 11  and —C(O)R 11 ;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided the compound of Formula IV is not 6-methoxy-3-(2-phenyl-thiazol-4-yl)-1H-quinolin-2-one, 3-(2-phenyl-thiazol-4-yl)-1H-quinolin-2-one, 3-(4-(3,4-dihydroxyphenyl)thiazol-2-yl)-1H-quinolin-2-one or 3-(2-(3,4-dimethoxyphenyl)thiazol-4-yl)-1H-quinolin-2-one.  
     
   
   
       75 . The method of  claim 42  wherein the compound has the following Formula IV  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino and phenyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein R 12  is one or more substituents selected from H, hydroxyl, halo, aryl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )alkenyl, —OR 11 , —O—C 1-2 -alkyl-O—, —N(R 11 ) 2 , —(C 1 -C 4 ) alkyl-N(R 11 ) 2 , lower alkoxyalkyl, R 11 —SO 2 —, (C 1 -C 4 )alkyl, cyano, nitro, lower cyanoalkyl, lower haloalkyl, lower hydroxyalkyl, lower aminoalkyl, lower alkylaminoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 6 ) cycloalkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 11 R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , —CO 2 NR 11 R 11 , —SO 2 NHC(O)R 11 , optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted heterocyclyl-(C 1 -C 4 )alkyl, —NR 11 C(O)N(R 11 ) 2 , —NR 11 C(O)R 11 , —NR 11 CO 2 R 11  and —C(O)R 11 ;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided the compound of Formula IV is not 6-methoxy-3-(2-phenyl-thiazol-4-yl)-1H-quinolin-2-one, 3-(2-phenyl-thiazol-4-yl)-1H-quinolin-2-one, 3-(4-(3,4-dihydroxyphenyl)thiazol-2-yl)-1H-quinolin-2-one or 3-(2-(3,4-dimethoxyphenyl)thiazol-4-yl)-1H-quinolin-2-one.  
     
   
   
       76 . The method of  claim 44  wherein the compound has the following Formula IV  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino and phenyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein R 12  is one or more substituents selected from H, hydroxyl, halo, aryl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )alkenyl, —OR 11 , —O—C 1-2 -alkyl-O—, —N(R 11 ) 2 , —(C 1 -C 4 ) alkyl-N(R 11 ) 2 , lower alkoxyalkyl, R 11 —SO 2 —, (C 1 -C 4 )alkyl, cyano, nitro, lower cyanoalkyl, lower haloalkyl, lower hydroxyalkyl, lower aminoalkyl, lower alkylaminoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 6 )cycloalkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 11 R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , —CO 2 NR 11 R 11 , —SO 2 NHC(O)R 11 , optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted heterocyclyl-(C 1 -C 4 )alkyl, —NR 11 C(O)N(R 11 ) 2 , —NR 11 C(O)R 11 , —NR 11 CO 2 R 11  and —C(O)R 11 ;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided the compound of Formula IV is not 6-methoxy-3-(2-phenyl-thiazol-4-yl)-1H-quinolin-2-one, 3-(2-phenyl-thiazol-4-yl)-1H-quinolin-2-one, 3-(4-(3,4-dihydroxyphenyl)thiazol-2-yl)-1H-quinolin-2-one or 3-(2-(3,4-dimethoxyphenyl)thiazol-4-yl)-1H-quinolin-2-one.  
     
   
   
       77 . The method of  claim 45  wherein the compound has the following Formula IV  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino and phenyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein R 12  is one or more substituents selected from H, hydroxyl, halo, aryl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )alkenyl, —OR 11 , —O—C 1-2 -alkyl-O—, —N(R 11 ) 2 , —(C 1 -C 4 )alkyl-N(R 11 ) 2 , lower alkoxyalkyl, R 11 —SO 2 —, (C 1 -C 4 )alkyl, cyano, nitro, lower cyanoalkyl, lower haloalkyl, lower hydroxyalkyl, lower aminoalkyl, lower alkylaminoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C 3 -C 6 )cycloalkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, —SO 2 NR 11 R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , —CO 2 NR 11 R 11 , —SO 2 NHC(O)R 11 , optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted heterocyclyl-(C 1 -C 4 )alkyl, —NR 11 C(O)N(R 11 ) 2 , —NR 11 C(O)R 11 , —NR 11 CO 2 R 11  and —C(O)R 11 ;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl;  
       provided the compound of Formula IV is not 6-methoxy-3-(2-phenyl-thiazol-4-yl)-1H-quinolin-2-one, 3-(2-phenyl-thiazol-4-yl)-1H-quinolin-2-one, 3-(4-(3,4-dihydroxyphenyl)thiazol-2-yl)-1H-quinolin-2-one or 3-(2-(3,4-dimethoxyphenyl)thiazol-4-yl)-1H-quinolin-2-one.  
     
   
   
       78 . The method of  claim 41  wherein the compound has the following Formula V  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino, hydroxyl and phenyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein R 13  is selected from amino, 5-6-membered heteroarylamino, R 11  sulfonyl-C 1-3 -alkyl and N—(R 11 sulfonyl)-N—(R 14 )amino;  
       wherein R 14  is C 1-2  alkyl;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl.  
     
   
   
       79 . The method of  claim 42  wherein the compound has the following Formula V  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino, hydroxyl and phenyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein R 13  is selected from amino, 5-6-membered heteroarylamino, R 11 sulfonyl-C 1-3 -alkyl and N—(R 11 sulfonyl)-N—(R 14 ) amino;  
       wherein R 14  is C 1-2  alkyl;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl.  
     
   
   
       80 . The method of  claim 44  wherein the compound has the following Formula V  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino, hydroxyl and phenyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein R 13  is selected from amino, 5-6-membered heteroarylamino, R 11 sulfonyl-C 1-3 -alkyl and N—(R 11 sulfonyl)-N—(R 14 ) amino;  
       wherein R 14  is C 1-2  alkyl;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl.  
     
   
   
       81 . The method of  claim 45  wherein the compound has the following Formula V  
     
       
         
         
             
             
         
       
       wherein Z is selected from H, amino, hydroxyl and phenyl;  
       wherein R 9  is one or more substituents selected from H, —OR 11 , chloro, fluoro, phenyl, —N(R 11 ) 2 , —(C 1 -C 2 )alkyl-N(R 11 ) 2 , —S(O) n —N(R 11 ) 2 , —S(O) n R 11 , (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, hydroxy-(C 1 -C 4 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 )-alkylamino, (C 1 -C 2 )-alkylamino-(C 1 -C 2 ) alkoxy, optionally substituted heterocyclyl selected from pyrrolidinyl, piperazinyl, piperidinyl, and morpholinyl, —C(O)R 11 , —NR 11 SO 2 R 11 , —C(O)N(R 11 ) 2 , —CO 2 R 11 , optionally substituted benzyl, optionally substituted 4-6 membered heterocyclyl-C 1 -C 2 -alkyl, —NR 11 C(O)R 11  and —NR 11 CO 2 R 11 ;  
       wherein R 11  is selected from H, (C 1 -C 6 )alkyl, optionally substituted phenyl, optionally substituted phenyl-(C 1 -C 4 )alkyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-(C 1 -C 4 )alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl-(C 1 -C 4 )alkyl and (C 1 -C 2 )haloalkyl;  
       wherein R 13  is selected from amino, 5-6-membered heteroarylamino, R 11 sulfonyl-C 1-3 -alkyl and N—(R 11 sulfonyl)-N—(R 14 ) amino;  
       wherein R 14  is C 1-2  alkyl;  
       wherein n is 0, 1 or 2; and  
       wherein each alkyl, phenyl, cycloalkyl, and heterocyclyl moiety is optionally substituted with one or more groups selected from halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 4 )alkylamino, (C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino, (C 1 -C 4 )haloalkyl, pyrrolidinyl, piperazinyl, piperidinyl, morpholinyl, and azetidinyl.