Gene overexpressed in cancer

Abstract

Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

1 . A protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof.  
     
     
         2 . A protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1, 2, 28, 29, 30, 31, 32, 51, 52, 60 and 61 or a fragment thereof.  
     
     
         3 . A composition for diagnosing or treating lung cancer comprising the protein or fragment thereof according to  claim 2 .  
     
     
         4 . A protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 22, 23, 24, 25, 26, 27, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 53, 54 and 55 or a fragment thereof.  
     
     
         5 . A composition for diagnosing or treating stomach cancer comprising the protein or fragment thereof according to  claim 4 .  
     
     
         6 . A protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 3, 7, 20, 21, 46, 47, 48, 49 and 50 or a fragment thereof.  
     
     
         7 . A composition for diagnosing or treating large bowel cancer comprising the protein or fragment thereof according to  claim 6 .  
     
     
         8 . A protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 14, 15, 16, 17, 18, 19, 43, 44, 45, 56, 57, 58, 59, 62, 63, 64 and 65 or a fragment thereof.  
     
     
         9 . A composition for diagnosing or treating liver cancer comprising the protein or fragment thereof according to  claim 8 .  
     
     
         10 . The protein or fragment thereof according to  claim 1 , wherein the gene has a nucleotide sequence represented by any of SEQ ID NOs: 1, 9, 10, 14, 20, 22, 24, 25, 26, 27, 28, 29, 32, 38, 39, 40, 44, 51, 52, 53, 54 and 58.  
     
     
         11 . The protein or fragment thereof according to  claim 1 , wherein the gene has a nucleotide sequence represented by any of SEQ ID NOs: 1, 9, 10, 14, 20, 22, 24, 25 and 26.  
     
     
         12 . The protein or fragment thereof according to  claim 1 , having an amino acid sequence represented by any of SEQ ID NOs: 66 to 123.  
     
     
         13 . An antibody recognizing the protein or fragment thereof according to  claim 1 .  
     
     
         14 . A polynucleotide having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto, and a polynucleotide hybridizing under high stringent conditions to any of said polynucleotides.  
     
     
         15 . The polynucleotide according to  claim 14  wherein said sequence comprises at least 12 consecutive nucleotides and wherein said polynucleotide has at least 12 nucleotides.  
     
     
         16 . The polynucleotide according to  claim 14 , having a nucleotide sequence represented by any of SEQ ID NOs: 1, 2, 28, 29, 30, 31, 32, 51, 52, 60 and 61.  
     
     
         17 . A composition for diagnosing or treating lung cancer comprising the polynucleotide according to  claim 16 .  
     
     
         18 . The polynucleotide according to  claim 14 , having a nucleotide sequence represented by any of SEQ ID NOs: 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 22, 23, 24, 25, 26, 27, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 53, 54 and 55.  
     
     
         19 . A composition for diagnosing or treating stomach cancer comprising the polynucleotide according to  claim 18 .  
     
     
         20 . The polynucleotide according to  claim 14  or  15 , having a nucleotide sequence represented by any of SEQ ID NOs: 3, 7, 20, 21, 46, 47, 48, 49 and 50.  
     
     
         21 . A composition for diagnosing or treating large bowel cancer comprising the polynucleotide according to  claim 20 .  
     
     
         22 . The polynucleotide according to  claim 14  or  15 , having a nucleotide sequence represented by any of SEQ ID NOs: 14, 15, 16, 17, 18, 19, 43, 44, 45, 56, 57, 58, 59, 62, 63, 64 and 65.  
     
     
         23 . A composition for diagnosing or treating lung cancer comprising the polynucleotide according to  claim 22 .  
     
     
         24 . The polynucleotide according to  claim 14  or  15 , having a nucleotide sequence represented by any of SEQ ID NOs: 1, 9, 10, 14, 20, 22, 24, 25, 26, 27, 28, 29, 32, 38, 39, 40, 44, 51, 52, 53, 54 and 58.  
     
     
         25 . A vector comprising the polynucleotide according to  claim 14 .  
     
     
         26 . A cell comprising the vector according to  claim 25 .  
     
     
         27 . A method of identifying a compound having an anticancer activity comprising the steps of: 
 bringing a cultured human cell into contact with a test compound; and    identifying a compound that causes a change in the expression level of a gene containing a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 in the cell as a compound having an anticancer activity.    
     
     
         28 . A method of diagnosing cancer comprising measuring the expression level of the protein according to  claim 1  or the polynucleotide according to  claim 14 .  
     
     
         29 - 37 . (canceled)