Compositions and Methods for the Diagnosis and Treatment of Tumor

Abstract

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

1 . An isolated antibody that binds to a polypeptide having at least 80% amino acid sequence identity to: 
 (a) the polypeptide shown in any one of  FIGS. 57-112 ,  114 ,  116 ,  118  or  120  (SEQ ID NOS:57-112, 114, 116, 118 or 120);    (b) the polypeptide shown in any one of  FIGS. 57-112 ,  114 ,  116 ,  118  or  120  (SEQ ID NOS:57-112, 114, 116, 118 or 120), lacking its associated signal peptide;    (c) an extracellular domain of the polypeptide shown in any one of  FIGS. 57-112 ,  114 ,  116 ,  118  or  120  (SEQ ID NOS:57-112, 114, 116, 118 or 120), with its associated signal peptide;    (d) an extracellular domain of the polypeptide shown in any one of  FIGS. 57-112 ,  114 ,  116 ,  118  or  120  (SEQ ID NOS:57-112, 114, 116, 118 or 120), lacking its associated signal peptide;    (e) a polypeptide encoded by the nucleotide sequence shown in any one of  FIGS. 1-56 ,  113 ,  115 ,  117  or  119  (SEQ ID NOS:1-56, 113, 115, 117 or 119); or    (f) a polypeptide encoded by the full-length coding region of the nucleotide sequence shown in any one of  FIGS. 1-56 ,  113 ,  115 ,  117  or  119  (SEQ ID NOS:1-56, 113, 115, 117 or 119).    
     
     
         2 . An isolated antibody that binds to a polypeptide having: 
 (a) the amino acid sequence shown in any one of  FIGS. 57-112 ,  114 ,  116 ,  118  or  120  (SEQ ID NOS:57-112, 114, 116, 118 or 120);    (b) the amino acid sequences shown in any one of  FIGS. 57-112 ,  114 ,  116 ,  118  or  120  (SEQ ID NOS:57-112, 114, 116, 118 or 120), lacking its associated signal peptide sequence;    (c) an amino acid sequence of an extracellular domain of the polypeptide shown in any one of  FIGS. 57-112 ,  114 ,  116 ,  118  or  120  (SEQ ID NOS:57-112, 114, 116, 118 or 120), with its associated signal peptide sequence;    (d) an amino acid sequence of an extracellular domain of the polypeptide shown in any one of  FIGS. 57-112 ,  114 ,  116 ,  118  or  120  (SEQ ID NOS:57-112, 114, 116, 118 or 120), lacking its associated signal peptide sequence;    (e) an amino acid sequence encoded by the nucleotide sequence shown in any one of  FIGS. 1-56 ,  113 ,  115 ,  117  or  119  (SEQ ID NOS:1-56, 113, 115, 117 or 119); or    (f) an amino acid sequence encoded by the full-length coding region of the nucleotide sequence shown in any one of  FIGS. 1-56 ,  113 ,  115 ,  117  or  119  (SEQ ID NOS:1-56, 113, 115, 117 or 119).    
     
     
         3 . The antibody of  claim 1  which is a monoclonal antibody.  
     
     
         4 . The antibody of  claim 1  which is an antibody fragment.  
     
     
         5 . The antibody of  claim 1  which is a chimeric or a humanized antibody.  
     
     
         6 . The antibody of  claim 1  which is conjugated to a growth inhibitory agent.  
     
     
         7 . The antibody of  claim 1  which is conjugated to a cytotoxic agent.  
     
     
         8 . The antibody of  claim 7 , wherein the cytotoxic agent is selected from the group consisting of toxins, antibiotics, radioactive isotopes and nucleolytic enzymes.  
     
     
         9 . The antibody of  claim 7 , wherein the cytotoxic agent is a toxin.  
     
     
         10 . The antibody of  claim 9 , wherein the toxin is selected from the group consisting of maytansinoid and calicheamicin.  
     
     
         11 . The antibody of  claim 9 , wherein the toxin is a maytansinoid.  
     
     
         12 . The antibody of  claim 1  which is produced in bacteria.  
     
     
         13 . The antibody of  claim 1  which is produced in CHO cells.  
     
     
         14 . The antibody of  claim 1  which induces death of a cell to which it binds.  
     
     
         15 . The antibody of  claim 1  which is detectably labeled.